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Example 11 with ParameterList

use of qupath.lib.plugins.parameters.ParameterList in project qupath by qupath.

the class QuPathGUI method runPlugin.

/**
 * Run a plugin, interactively (i.e. launching a dialog) if necessary.
 * <p>
 * Note that this does not in itself perform any exception handling.
 *
 * @param plugin the plugin to run
 * @param arg optional string argument (usually JSON)
 * @param doInteractive if true, show an interactive dialog if the plugin is an instance of {@link PathInteractivePlugin}
 * @return true if running the plugin was successful and was not cancelled.
 *              Note that if {@code doInteractive == true} and the dialog was launched
 *              but not run, this will also return true.
 * @throws Exception
 */
public boolean runPlugin(final PathPlugin<BufferedImage> plugin, final String arg, final boolean doInteractive) throws Exception {
    // TODO: Check safety...
    if (doInteractive && plugin instanceof PathInteractivePlugin) {
        PathInteractivePlugin<BufferedImage> pluginInteractive = (PathInteractivePlugin<BufferedImage>) plugin;
        ParameterList params = pluginInteractive.getDefaultParameterList(getImageData());
        // Update parameter list, if necessary
        if (arg != null) {
            Map<String, String> map = GeneralTools.parseArgStringValues(arg);
            // We use the US locale because we need to ensure decimal points (not commas)
            ParameterList.updateParameterList(params, map, Locale.US);
        }
        var runner = new PluginRunnerFX(this);
        ParameterDialogWrapper<BufferedImage> dialog = new ParameterDialogWrapper<>(pluginInteractive, params, runner);
        dialog.showDialog();
        return !runner.isCancelled();
    } else {
        try {
            pluginRunning.set(true);
            var runner = new PluginRunnerFX(this);
            @SuppressWarnings("unused") var completed = plugin.runPlugin(runner, arg);
            return !runner.isCancelled();
        } finally {
            pluginRunning.set(false);
        }
    }
// } catch (Exception e) {
// logger.error("Unable to run plugin " + plugin, e);
// return false;
// }
}
Also used : PathInteractivePlugin(qupath.lib.plugins.PathInteractivePlugin) ParameterList(qupath.lib.plugins.parameters.ParameterList) BufferedImage(java.awt.image.BufferedImage)

Example 12 with ParameterList

use of qupath.lib.plugins.parameters.ParameterList in project qupath by qupath.

the class AbstractTileableDetectionPlugin method addRunnableTasks.

/**
 * Intercepts the 'standard' addRunnableTasks to (if necessary) insert ParallelTileObjects along the way,
 * thereby breaking an excessively-large parentObject into more manageable pieces.
 * <p>
 * TODO: Avoid hard-coding what is considered a 'manageable size' or a preferred size for parallel tiles.
 */
@Override
protected void addRunnableTasks(ImageData<T> imageData, PathObject parentObject, List<Runnable> tasks) {
    if (imageData == null)
        return;
    ParameterList params = getParameterList(imageData);
    // Determine appropriate sizes
    // Note, for v0.1.2 and earlier the downsample was restricted to be a power of 2
    double downsampleFactor = ServerTools.getDownsampleFactor(imageData.getServer(), getPreferredPixelSizeMicrons(imageData, params));
    int preferred = (int) (PREFERRED_TILE_SIZE * downsampleFactor);
    int max = (int) (MAX_TILE_SIZE * downsampleFactor);
    ImmutableDimension sizePreferred = ImmutableDimension.getInstance(preferred, preferred);
    ImmutableDimension sizeMax = ImmutableDimension.getInstance(max, max);
    // parentObject.clearPathObjects();
    // Extract (or create) suitable ROI
    ROI parentROI = parentObject.getROI();
    if (parentROI == null)
        parentROI = ROIs.createRectangleROI(0, 0, imageData.getServer().getWidth(), imageData.getServer().getHeight(), ImagePlane.getDefaultPlane());
    // Make tiles
    Collection<? extends ROI> pathROIs = RoiTools.computeTiledROIs(parentROI, sizePreferred, sizeMax, false, getTileOverlap(imageData, params));
    // No tasks to complete
    if (pathROIs.isEmpty())
        return;
    // // Exactly one task to complete
    // if (pathROIs.size() == 1 && pathROIs.iterator().next() == parentObject.getROI()) {
    // tasks.add(DetectionPluginTools.createRunnableTask(createDetector(imageData, params), getParameterList(imageData), imageData, parentObject));
    // return;
    // }
    ParallelDetectionTileManager manager = new ParallelDetectionTileManager(parentObject);
    List<ParallelTileObject> tileList = new ArrayList<>();
    AtomicInteger countdown = new AtomicInteger(pathROIs.size());
    for (ROI pathROI : pathROIs) {
        ParallelTileObject tile = new ParallelTileObject(manager, pathROI, imageData.getHierarchy(), countdown);
        parentObject.addPathObject(tile);
        for (ParallelTileObject tileTemp : tileList) {
            if (tileTemp.suggestNeighbor(tile))
                tile.suggestNeighbor(tileTemp);
        }
        tileList.add(tile);
        tasks.add(DetectionPluginTools.createRunnableTask(createDetector(imageData, params), params, imageData, tile));
    }
    manager.setTiles(tileList);
    imageData.getHierarchy().fireHierarchyChangedEvent(this);
}
Also used : AtomicInteger(java.util.concurrent.atomic.AtomicInteger) ArrayList(java.util.ArrayList) ParameterList(qupath.lib.plugins.parameters.ParameterList) ImmutableDimension(qupath.lib.geom.ImmutableDimension) ROI(qupath.lib.roi.interfaces.ROI)

Example 13 with ParameterList

use of qupath.lib.plugins.parameters.ParameterList in project qupath by qupath.

the class AbstractInteractivePlugin method getLoggableParameters.

/**
 * Get a copy of the current parameter list (with empty parameters removed) suitable for logging.
 * Subclasses might choose to append extra parameters here, which aren't part of the main list
 * (e.g. because they shouldn't be included in any automatically created dialog box)
 * @param imageData
 * @return
 */
protected ParameterList getLoggableParameters(final ImageData<T> imageData) {
    ParameterList params = getParameterList(imageData).duplicate();
    params.removeEmptyParameters();
    return params;
}
Also used : ParameterList(qupath.lib.plugins.parameters.ParameterList)

Example 14 with ParameterList

use of qupath.lib.plugins.parameters.ParameterList in project qupath by qupath.

the class KaplanMeierDisplay method generatePlot.

@SuppressWarnings("unchecked")
private void generatePlot() {
    KaplanMeierDisplay.ScoreData newScoreData = scoreData;
    // If we have a hierarchy, update the scores with the most recent data
    if (hierarchy != null) {
        List<TMACoreObject> cores = PathObjectTools.getTMACoreObjects(hierarchy, false);
        double[] survival = new double[cores.size()];
        boolean[] censored = new boolean[cores.size()];
        double[] scores = new double[cores.size()];
        // scoreColumn = "RoughScore";
        for (int i = 0; i < cores.size(); i++) {
            TMACoreObject core = cores.get(i);
            MeasurementList ml = core.getMeasurementList();
            survival[i] = core.getMeasurementList().getMeasurementValue(survivalColumn);
            double censoredValue = core.getMeasurementList().getMeasurementValue(censoredColumn);
            boolean hasCensoredValue = !Double.isNaN(censoredValue) && (censoredValue == 0 || censoredValue == 1);
            censored[i] = censoredValue != 0;
            if (!hasCensoredValue) {
                // If we don't have a censored value, ensure we mask out everything else
                scores[i] = Double.NaN;
                survival[i] = Double.NaN;
            } else if (ml.containsNamedMeasurement(scoreColumn))
                // Get the score if we can
                scores[i] = ml.getMeasurementValue(scoreColumn);
            else {
                // // Try to compute score if we need to
                // Map<String, Number> map = ROIMeaningfulMeasurements.getPathClassSummaryMeasurements(core.getChildObjects(), true);
                // Number value = map.get(scoreColumn);
                // if (value == null)
                scores[i] = Double.NaN;
            // else
            // scores[i] = value.doubleValue();
            }
        }
        // Mask out any scores that don't have associated survival data
        for (int i = 0; i < survival.length; i++) {
            if (Double.isNaN(survival[i]))
                scores[i] = Double.NaN;
        }
        newScoreData = new ScoreData(scores, survival, censored);
    }
    if (newScoreData == null || newScoreData.scores.length == 0)
        return;
    // KaplanMeier kmHigh = new KaplanMeier("Above threshold");
    // KaplanMeier kmLow = new KaplanMeier("Below threshold");
    double[] quartiles = StatisticsHelper.getQuartiles(newScoreData.scores);
    double q1 = quartiles[0];
    double median = quartiles[1];
    double q3 = quartiles[2];
    double[] thresholds;
    if (params != null) {
        Object thresholdMethod = params.getChoiceParameterValue("scoreThresholdMethod");
        if (thresholdMethod.equals("Median")) {
            // panelParams.setNumericParameterValue("scoreThreshold", median);
            // ((DoubleParameter)params.getParameters().get("scoreThreshold")).setValue(median); // TODO: UPDATE DIALOG!
            thresholds = new double[] { median };
        } else if (thresholdMethod.equals("Tertiles")) {
            // ((DoubleParameter)params.getParameters().get("scoreThreshold")).setValue(median); // TODO: UPDATE DIALOG!
            thresholds = StatisticsHelper.getTertiles(newScoreData.scores);
        } else if (thresholdMethod.equals("Quartiles")) {
            // ((DoubleParameter)params.getParameters().get("scoreThreshold")).setValue(median); // TODO: UPDATE DIALOG!
            thresholds = new double[] { q1, median, q3 };
        } else if (thresholdMethod.equals("Manual (1)")) {
            thresholds = new double[] { params.getDoubleParameterValue("threshold1") };
        } else if (thresholdMethod.equals("Manual (2)")) {
            thresholds = new double[] { params.getDoubleParameterValue("threshold1"), params.getDoubleParameterValue("threshold2") };
        } else
            // if (thresholdMethod.equals("Manual (3)")) {
            thresholds = new double[] { params.getDoubleParameterValue("threshold1"), params.getDoubleParameterValue("threshold2"), params.getDoubleParameterValue("threshold3") };
    } else
        thresholds = new double[] { median };
    double minVal = Double.POSITIVE_INFINITY;
    double maxVal = Double.NEGATIVE_INFINITY;
    int numNonNaN = 0;
    for (double d : newScoreData.scores) {
        if (Double.isNaN(d))
            continue;
        if (d < minVal)
            minVal = d;
        if (d > maxVal)
            maxVal = d;
        numNonNaN++;
    }
    // If not this, we don't have valid scores that we can work with
    boolean scoresValid = maxVal > minVal;
    double maxTimePoint = 0;
    for (double d : newScoreData.survival) {
        if (Double.isNaN(d))
            continue;
        if (d > maxTimePoint)
            maxTimePoint = d;
    }
    if (panelParams != null && maxTimePoint > ((IntParameter) params.getParameters().get("censorTimePoints")).getUpperBound()) {
        panelParams.setNumericParameterValueRange("censorTimePoints", 0, Math.ceil(maxTimePoint));
    }
    // Optionally censor at specified time
    double censorThreshold = params == null ? maxTimePoint : params.getIntParameterValue("censorTimePoints");
    // Compute log-rank p-values for *all* possible thresholds
    // Simultaneously determine the threshold that yields the lowest p-value,
    // resolving ties in favour of a more even split between high/low numbers of events
    boolean pValuesChanged = false;
    if (calculateAllPValues) {
        if (!(pValues != null && pValueThresholds != null && newScoreData.equals(scoreData) && censorThreshold == lastPValueCensorThreshold)) {
            Map<Double, Double> mapLogRank = new TreeMap<>();
            Set<Double> setObserved = new HashSet<>();
            for (int i = 0; i < newScoreData.scores.length; i++) {
                Double d = newScoreData.scores[i];
                boolean observed = !newScoreData.censored[i] && newScoreData.survival[i] < censorThreshold;
                if (observed)
                    setObserved.add(d);
                if (mapLogRank.containsKey(d))
                    continue;
                List<KaplanMeierData> kmsTemp = splitByThresholds(newScoreData, new double[] { d }, censorThreshold, false);
                // if (kmsTemp.get(1).nObserved() == 0 || kmsTemp.get(1).nObserved() == 0)
                // continue;
                LogRankResult test = LogRankTest.computeLogRankTest(kmsTemp.get(0), kmsTemp.get(1));
                double pValue = test.getPValue();
                // double pValue = test.hazardRatio < 1 ? test.hazardRatio : 1.0/test.hazardRatio; // Checking usefulness of Hazard ratios...
                if (!Double.isFinite(pValue))
                    continue;
                // if (!Double.isFinite(test.getHazardRatio())) {
                // //						continue;
                // pValue = Double.NaN;
                // }
                mapLogRank.put(d, pValue);
            }
            pValueThresholds = new double[mapLogRank.size()];
            pValues = new double[mapLogRank.size()];
            pValueThresholdsObserved = new boolean[mapLogRank.size()];
            int count = 0;
            for (Entry<Double, Double> entry : mapLogRank.entrySet()) {
                pValueThresholds[count] = entry.getKey();
                pValues[count] = entry.getValue();
                if (setObserved.contains(entry.getKey()))
                    pValueThresholdsObserved[count] = true;
                count++;
            }
            // Find the longest 'significant' stretch
            int maxSigCount = 0;
            int maxSigInd = -1;
            int sigCurrent = 0;
            int[] sigCount = new int[pValues.length];
            for (int i = 0; i < pValues.length; i++) {
                if (pValues[i] < 0.05) {
                    sigCurrent++;
                    sigCount[i] = sigCurrent;
                    if (sigCurrent > maxSigCount) {
                        maxSigCount = sigCurrent;
                        maxSigInd = i;
                    }
                } else
                    sigCurrent = 0;
            }
            if (maxSigCount == 0) {
                logger.info("No p-values < 0.05");
            } else {
                double minThresh = maxSigInd - maxSigCount < 0 ? pValueThresholds[0] - 0.0000001 : pValueThresholds[maxSigInd - maxSigCount];
                double maxThresh = pValueThresholds[maxSigInd];
                int nBetween = 0;
                int nBetweenObserved = 0;
                for (int i = 0; i < newScoreData.scores.length; i++) {
                    if (newScoreData.scores[i] > minThresh && newScoreData.scores[i] <= maxThresh) {
                        nBetween++;
                        if (newScoreData.survival[i] < censorThreshold && !newScoreData.censored[i])
                            nBetweenObserved++;
                    }
                }
                logger.info("Longest stretch of p-values < 0.05: {} - {} ({} entries, {} observed)", minThresh, maxThresh, nBetween, nBetweenObserved);
            }
            pValuesSmoothed = new double[pValues.length];
            Arrays.fill(pValuesSmoothed, Double.NaN);
            int n = (pValues.length / 20) * 2 + 1;
            logger.info("Smoothing log-rank test p-values by " + n);
            for (int i = n / 2; i < pValues.length - n / 2; i++) {
                double sum = 0;
                for (int k = i - n / 2; k < i - n / 2 + n; k++) {
                    sum += pValues[k];
                }
                pValuesSmoothed[i] = sum / n;
            }
            // for (int i = 0; i < pValues.length; i++) {
            // double sum = 0;
            // for (int k = Math.max(0, i-n/2); k < Math.min(pValues.length, i-n/2+n); k++) {
            // sum += pValues[k];
            // }
            // pValuesSmoothed[i] = sum/n;
            // }
            // pValues = pValuesSmoothed;
            lastPValueCensorThreshold = censorThreshold;
            pValuesChanged = true;
        }
    } else {
        lastPValueCensorThreshold = Double.NaN;
        pValueThresholds = null;
        pValues = null;
    }
    // if (params != null && !Double.isNaN(bestThreshold) && (params.getChoiceParameterValue("scoreThresholdMethod").equals("Lowest p-value")))
    if (params != null && (params.getChoiceParameterValue("scoreThresholdMethod").equals("Lowest p-value"))) {
        int bestIdx = -1;
        double bestPValue = Double.POSITIVE_INFINITY;
        for (int i = pValueThresholds.length / 10; i < pValueThresholds.length * 9 / 10; i++) {
            if (pValues[i] < bestPValue) {
                bestIdx = i;
                bestPValue = pValues[i];
            }
        }
        thresholds = bestIdx >= 0 ? new double[] { pValueThresholds[bestIdx] } : new double[0];
    } else if (params != null && (params.getChoiceParameterValue("scoreThresholdMethod").equals("Lowest smoothed p-value"))) {
        int bestIdx = -1;
        double bestPValue = Double.POSITIVE_INFINITY;
        for (int i = pValueThresholds.length / 10; i < pValueThresholds.length * 9 / 10; i++) {
            if (pValuesSmoothed[i] < bestPValue) {
                bestIdx = i;
                bestPValue = pValuesSmoothed[i];
            }
        }
        thresholds = bestIdx >= 0 ? new double[] { pValueThresholds[bestIdx] } : new double[0];
    }
    // Split into different curves using the provided thresholds
    List<KaplanMeierData> kms = splitByThresholds(newScoreData, thresholds, censorThreshold, params != null && "Quartiles".equals(params.getChoiceParameterValue("scoreThresholdMethod")));
    if (plotter == null) {
        plotter = new KaplanMeierChartWrapper(survivalColumn + " time");
    // plotter.setBorder(BorderFactory.createTitledBorder("Survival plot"));
    // plotter.getCanvas().setWidth(300);
    // plotter.getCanvas().setHeight(300);
    }
    KaplanMeierData[] kmArray = new KaplanMeierData[kms.size()];
    plotter.setKaplanMeierCurves(survivalColumn + " time", kms.toArray(kmArray));
    tableModel.setSurvivalCurves(thresholds, params != null && params.getChoiceParameterValue("scoreThresholdMethod").equals("Lowest p-value"), kmArray);
    // Bar width determined using 'Freedman and Diaconis' rule' (but overridden if this gives < 16 bins...)
    double barWidth = (2 * q3 - q1) * Math.pow(numNonNaN, -1.0 / 3.0);
    int nBins = 100;
    if (!Double.isNaN(barWidth))
        barWidth = (int) Math.max(16, Math.ceil((maxVal - minVal) / barWidth));
    Histogram histogram = scoresValid ? new Histogram(newScoreData.scores, nBins) : null;
    if (histogramPanel == null) {
        GridPane paneHistogram = new GridPane();
        histogramPanel = new HistogramPanelFX();
        histogramPanel.getChart().setAnimated(false);
        histogramWrapper = new ThresholdedChartWrapper(histogramPanel.getChart());
        for (ObservableNumberValue val : threshProperties) histogramWrapper.addThreshold(val, ColorToolsFX.getCachedColor(240, 0, 0, 128));
        histogramWrapper.getPane().setPrefHeight(150);
        paneHistogram.add(histogramWrapper.getPane(), 0, 0);
        Tooltip.install(histogramPanel.getChart(), new Tooltip("Distribution of scores"));
        GridPane.setHgrow(histogramWrapper.getPane(), Priority.ALWAYS);
        GridPane.setVgrow(histogramWrapper.getPane(), Priority.ALWAYS);
        NumberAxis xAxis = new NumberAxis();
        xAxis.setLabel("Score threshold");
        NumberAxis yAxis = new NumberAxis();
        yAxis.setLowerBound(0);
        yAxis.setUpperBound(1);
        yAxis.setTickUnit(0.1);
        yAxis.setAutoRanging(false);
        yAxis.setLabel("P-value");
        chartPValues = new LineChart<>(xAxis, yAxis);
        chartPValues.setAnimated(false);
        chartPValues.setLegendVisible(false);
        // Make chart so it can be navigated
        ChartTools.makeChartInteractive(chartPValues, xAxis, yAxis);
        pValuesChanged = true;
        Tooltip.install(chartPValues, new Tooltip("Distribution of p-values (log-rank test) comparing low vs. high for all possible score thresholds"));
        // chartPValues.getYAxis().setAutoRanging(false);
        pValuesWrapper = new ThresholdedChartWrapper(chartPValues);
        for (ObservableNumberValue val : threshProperties) pValuesWrapper.addThreshold(val, ColorToolsFX.getCachedColor(240, 0, 0, 128));
        pValuesWrapper.getPane().setPrefHeight(150);
        paneHistogram.add(pValuesWrapper.getPane(), 0, 1);
        GridPane.setHgrow(pValuesWrapper.getPane(), Priority.ALWAYS);
        GridPane.setVgrow(pValuesWrapper.getPane(), Priority.ALWAYS);
        ContextMenu popup = new ContextMenu();
        ChartTools.addChartExportMenu(chartPValues, popup);
        RadioMenuItem miZoomY1 = new RadioMenuItem("0-1");
        miZoomY1.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(1);
            yAxis.setTickUnit(0.2);
        });
        RadioMenuItem miZoomY05 = new RadioMenuItem("0-0.5");
        miZoomY05.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(0.5);
            yAxis.setTickUnit(0.1);
        });
        RadioMenuItem miZoomY02 = new RadioMenuItem("0-0.2");
        miZoomY02.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(0.2);
            yAxis.setTickUnit(0.05);
        });
        RadioMenuItem miZoomY01 = new RadioMenuItem("0-0.1");
        miZoomY01.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(0.1);
            yAxis.setTickUnit(0.05);
        });
        RadioMenuItem miZoomY005 = new RadioMenuItem("0-0.05");
        miZoomY005.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(0.05);
            yAxis.setTickUnit(0.01);
        });
        RadioMenuItem miZoomY001 = new RadioMenuItem("0-0.01");
        miZoomY001.setOnAction(e -> {
            yAxis.setAutoRanging(false);
            yAxis.setUpperBound(0.01);
            yAxis.setTickUnit(0.005);
        });
        ToggleGroup tgZoom = new ToggleGroup();
        miZoomY1.setToggleGroup(tgZoom);
        miZoomY05.setToggleGroup(tgZoom);
        miZoomY02.setToggleGroup(tgZoom);
        miZoomY01.setToggleGroup(tgZoom);
        miZoomY005.setToggleGroup(tgZoom);
        miZoomY001.setToggleGroup(tgZoom);
        Menu menuZoomY = new Menu("Set y-axis range");
        menuZoomY.getItems().addAll(miZoomY1, miZoomY05, miZoomY02, miZoomY01, miZoomY005, miZoomY001);
        MenuItem miCopyData = new MenuItem("Copy chart data");
        miCopyData.setOnAction(e -> {
            String dataString = ChartTools.getChartDataAsString(chartPValues);
            ClipboardContent content = new ClipboardContent();
            content.putString(dataString);
            Clipboard.getSystemClipboard().setContent(content);
        });
        popup.getItems().addAll(miCopyData, menuZoomY);
        chartPValues.setOnContextMenuRequested(e -> {
            popup.show(chartPValues, e.getScreenX(), e.getScreenY());
        });
        for (int col = 0; col < tableModel.getColumnCount(); col++) {
            TableColumn<Integer, String> column = new TableColumn<>(tableModel.getColumnName(col));
            int colNumber = col;
            column.setCellValueFactory(new Callback<CellDataFeatures<Integer, String>, ObservableValue<String>>() {

                @Override
                public ObservableValue<String> call(CellDataFeatures<Integer, String> p) {
                    return new SimpleStringProperty((String) tableModel.getValueAt(p.getValue(), colNumber));
                }
            });
            column.setCellFactory(new Callback<TableColumn<Integer, String>, TableCell<Integer, String>>() {

                @Override
                public TableCell<Integer, String> call(TableColumn<Integer, String> param) {
                    TableCell<Integer, String> cell = new TableCell<Integer, String>() {

                        @Override
                        protected void updateItem(String item, boolean empty) {
                            super.updateItem(item, empty);
                            setText(item);
                            setTooltip(new Tooltip(item));
                        }
                    };
                    return cell;
                }
            });
            table.getColumns().add(column);
        }
        table.setPrefHeight(250);
        table.setColumnResizePolicy(TableView.CONSTRAINED_RESIZE_POLICY);
        table.maxHeightProperty().bind(table.prefHeightProperty());
        params = new ParameterList();
        // maxTimePoint = 0;
        // for (TMACoreObject core : hierarchy.getTMAGrid().getTMACoreList()) {
        // double os = core.getMeasurementList().getMeasurementValue(TMACoreObject.KEY_OVERALL_SURVIVAL);
        // double rfs = core.getMeasurementList().getMeasurementValue(TMACoreObject.KEY_RECURRENCE_FREE_SURVIVAL);
        // if (os > maxTimePoint)
        // maxTimePoint = os;
        // if (rfs > maxTimePoint)
        // maxTimePoint = rfs;
        // }
        params.addIntParameter("censorTimePoints", "Max censored time", (int) (censorThreshold + 0.5), null, 0, (int) Math.ceil(maxTimePoint), "Latest time point beyond which data will be censored");
        // params.addChoiceParameter("scoreThresholdMethod", "Threshold method", "Manual", Arrays.asList("Manual", "Median", "Log-rank test"));
        if (calculateAllPValues)
            // Don't include "Lowest smoothed p-value" - it's not an established method and open to misinterpretation...
            params.addChoiceParameter("scoreThresholdMethod", "Threshold method", "Median", Arrays.asList("Manual (1)", "Manual (2)", "Manual (3)", "Median", "Tertiles", "Quartiles", "Lowest p-value"));
        else
            // params.addChoiceParameter("scoreThresholdMethod", "Threshold method", "Median", Arrays.asList("Manual (1)", "Manual (2)", "Manual (3)", "Median", "Tertiles", "Quartiles", "Lowest p-value", "Lowest smoothed p-value"));
            params.addChoiceParameter("scoreThresholdMethod", "Threshold method", "Median", Arrays.asList("Manual (1)", "Manual (2)", "Manual (3)", "Median", "Tertiles", "Quartiles"));
        params.addDoubleParameter("threshold1", "Threshold 1", thresholds.length > 0 ? thresholds[0] : (minVal + maxVal) / 2, null, "Threshold to distinguish between patient groups");
        params.addDoubleParameter("threshold2", "Threshold 2", thresholds.length > 1 ? thresholds[1] : (minVal + maxVal) / 2, null, "Threshold to distinguish between patient groups");
        params.addDoubleParameter("threshold3", "Threshold 3", thresholds.length > 2 ? thresholds[2] : (minVal + maxVal) / 2, null, "Threshold to distinguish between patient groups");
        params.addBooleanParameter("showAtRisk", "Show at risk", plotter.getShowAtRisk(), "Show number of patients at risk below the plot");
        params.addBooleanParameter("showTicks", "Show censored ticks", plotter.getShowCensoredTicks(), "Show ticks to indicate censored data");
        params.addBooleanParameter("showKey", "Show key", plotter.getShowKey(), "Show key indicating display of each curve");
        // Hide threshold parameters if threshold can't be used
        if (!scoresValid) {
            // params.setHiddenParameters(true, "scoreThresholdMethod", "scoreThreshold");
            histogramPanel.getChart().setVisible(false);
        }
        panelParams = new ParameterPanelFX(params);
        panelParams.addParameterChangeListener(this);
        updateThresholdsEnabled();
        for (int i = 0; i < threshProperties.length; i++) {
            String p = "threshold" + (i + 1);
            threshProperties[i].addListener((v, o, n) -> {
                if (interactiveThresholds()) {
                    // Need to do a decent double check with tolerance to text field value changing while typing
                    if (!GeneralTools.almostTheSame(params.getDoubleParameterValue(p), n.doubleValue(), 0.0001))
                        panelParams.setNumericParameterValue(p, n);
                }
            });
        }
        BorderPane paneBottom = new BorderPane();
        TitledPane paneOptions = new TitledPane("Options", panelParams.getPane());
        // paneOptions.setCollapsible(false);
        Pane paneCanvas = new StackPane();
        paneCanvas.getChildren().add(plotter.getCanvas());
        GridPane paneLeft = new GridPane();
        paneLeft.add(paneOptions, 0, 0);
        paneLeft.add(table, 0, 1);
        GridPane.setHgrow(paneOptions, Priority.ALWAYS);
        GridPane.setHgrow(table, Priority.ALWAYS);
        paneBottom.setLeft(paneLeft);
        paneBottom.setCenter(paneHistogram);
        paneMain.setCenter(paneCanvas);
        paneMain.setBottom(paneBottom);
        paneMain.setPadding(new Insets(10, 10, 10, 10));
    } else if (thresholds.length > 0) {
        // Ensure the sliders/text fields are set sensibly
        if (!GeneralTools.almostTheSame(thresholds[0], params.getDoubleParameterValue("threshold1"), 0.0001)) {
            panelParams.setNumericParameterValue("threshold1", thresholds[0]);
        }
        if (thresholds.length > 1 && !GeneralTools.almostTheSame(thresholds[1], params.getDoubleParameterValue("threshold2"), 0.0001)) {
            panelParams.setNumericParameterValue("threshold2", thresholds[1]);
        }
        if (thresholds.length > 2 && !GeneralTools.almostTheSame(thresholds[2], params.getDoubleParameterValue("threshold3"), 0.0001)) {
            panelParams.setNumericParameterValue("threshold3", thresholds[2]);
        }
    }
    if (histogram != null) {
        histogramPanel.getHistogramData().setAll(HistogramPanelFX.createHistogramData(histogram, false, (Color) null));
        histogramPanel.getChart().getXAxis().setLabel(scoreColumn);
        histogramPanel.getChart().getYAxis().setLabel("Count");
        ChartTools.addChartExportMenu(histogramPanel.getChart(), null);
    // histogramWrapper.setVerticalLines(thresholds, ColorToolsFX.getCachedColor(240, 0, 0, 128));
    // Deal with threshold adjustment
    // histogramWrapper.getThresholds().addListener((Observable o) -> generatePlot());
    }
    if (pValues != null) {
        // TODO: Raise earlier where p-value calculation is
        if (pValuesChanged) {
            ObservableList<XYChart.Data<Number, Number>> data = FXCollections.observableArrayList();
            for (int i = 0; i < pValueThresholds.length; i++) {
                double pValue = pValues[i];
                if (Double.isNaN(pValue))
                    continue;
                data.add(new XYChart.Data<>(pValueThresholds[i], pValue, pValueThresholdsObserved[i]));
            }
            ObservableList<XYChart.Data<Number, Number>> dataSmoothed = null;
            if (pValuesSmoothed != null) {
                dataSmoothed = FXCollections.observableArrayList();
                for (int i = 0; i < pValueThresholds.length; i++) {
                    double pValueSmoothed = pValuesSmoothed[i];
                    if (Double.isNaN(pValueSmoothed))
                        continue;
                    dataSmoothed.add(new XYChart.Data<>(pValueThresholds[i], pValueSmoothed));
                }
            }
            // Don't bother showing the smoothed data... it tends to get in the way...
            // if (dataSmoothed != null)
            // chartPValues.getData().setAll(new XYChart.Series<>("P-values", data), new XYChart.Series<>("Smoothed P-values", dataSmoothed));
            // else
            chartPValues.getData().setAll(new XYChart.Series<>("P-values", data));
            // Add line to show 0.05 significance threshold
            if (pValueThresholds.length > 1) {
                Data<Number, Number> sigData1 = new Data<>(pValueThresholds[0], 0.05);
                Data<Number, Number> sigData2 = new Data<>(pValueThresholds[pValueThresholds.length - 1], 0.05);
                XYChart.Series<Number, Number> dataSignificant = new XYChart.Series<>("Significance 0.05", FXCollections.observableArrayList(sigData1, sigData2));
                chartPValues.getData().add(dataSignificant);
                sigData1.getNode().setVisible(false);
                sigData2.getNode().setVisible(false);
            }
            // pValuesWrapper.clearThresholds();
            for (XYChart.Data<Number, Number> dataPoint : data) {
                if (!Boolean.TRUE.equals(dataPoint.getExtraValue()))
                    dataPoint.getNode().setVisible(false);
            }
        // if (dataSmoothed != null) {
        // for (XYChart.Data<Number, Number> dataPoint : dataSmoothed) {
        // dataPoint.getNode().setVisible(false);
        // }
        // chartPValues.getData().get(1).getNode().setOpacity(0.5);
        // }
        // int count = 0;
        // for (int i = 0; i < pValueThresholds.length; i++) {
        // double pValue = pValues[i];
        // if (Double.isNaN(pValue))
        // continue;
        // boolean observed = pValueThresholdsObserved[i];
        // //						if (observed)
        // //							pValuesWrapper.addThreshold(new ReadOnlyDoubleWrapper(pValueThresholds[i]), Color.rgb(0, 0, 0, 0.05));
        // 
        // if (!observed) {
        // //							StackPane pane = (StackPane)data.get(count).getNode();
        // //							pane.setEffect(new DropShadow());
        // data.get(count).getNode().setVisible(false);
        // }
        // count++;
        // }
        }
        for (int i = 0; i < threshProperties.length; i++) {
            if (i < thresholds.length)
                threshProperties[i].set(thresholds[i]);
            else
                threshProperties[i].set(Double.NaN);
        }
        boolean isInteractive = interactiveThresholds();
        histogramWrapper.setIsInteractive(isInteractive);
        pValuesWrapper.setIsInteractive(isInteractive);
        chartPValues.setVisible(true);
    }
    // else
    // chartPValues.setVisible(false);
    // Store values for next time
    scoreData = newScoreData;
}
Also used : Histogram(qupath.lib.analysis.stats.Histogram) CellDataFeatures(javafx.scene.control.TableColumn.CellDataFeatures) ObservableValue(javafx.beans.value.ObservableValue) ThresholdedChartWrapper(qupath.lib.gui.charts.HistogramPanelFX.ThresholdedChartWrapper) StackPane(javafx.scene.layout.StackPane) HashSet(java.util.HashSet) ObservableNumberValue(javafx.beans.value.ObservableNumberValue) GridPane(javafx.scene.layout.GridPane) TMACoreObject(qupath.lib.objects.TMACoreObject) Tooltip(javafx.scene.control.Tooltip) Color(javafx.scene.paint.Color) SimpleStringProperty(javafx.beans.property.SimpleStringProperty) TableColumn(javafx.scene.control.TableColumn) StackPane(javafx.scene.layout.StackPane) Pane(javafx.scene.layout.Pane) BorderPane(javafx.scene.layout.BorderPane) GridPane(javafx.scene.layout.GridPane) TitledPane(javafx.scene.control.TitledPane) ParameterList(qupath.lib.plugins.parameters.ParameterList) XYChart(javafx.scene.chart.XYChart) TMACoreObject(qupath.lib.objects.TMACoreObject) HistogramPanelFX(qupath.lib.gui.charts.HistogramPanelFX) LogRankResult(qupath.lib.analysis.stats.survival.LogRankTest.LogRankResult) IntParameter(qupath.lib.plugins.parameters.IntParameter) BorderPane(javafx.scene.layout.BorderPane) NumberAxis(javafx.scene.chart.NumberAxis) Insets(javafx.geometry.Insets) ClipboardContent(javafx.scene.input.ClipboardContent) MeasurementList(qupath.lib.measurements.MeasurementList) ContextMenu(javafx.scene.control.ContextMenu) RadioMenuItem(javafx.scene.control.RadioMenuItem) KaplanMeierData(qupath.lib.analysis.stats.survival.KaplanMeierData) ParameterPanelFX(qupath.lib.gui.dialogs.ParameterPanelFX) TableCell(javafx.scene.control.TableCell) ContextMenu(javafx.scene.control.ContextMenu) Menu(javafx.scene.control.Menu) TitledPane(javafx.scene.control.TitledPane) MenuItem(javafx.scene.control.MenuItem) RadioMenuItem(javafx.scene.control.RadioMenuItem) KaplanMeierData(qupath.lib.analysis.stats.survival.KaplanMeierData) Data(javafx.scene.chart.XYChart.Data) TreeMap(java.util.TreeMap) ToggleGroup(javafx.scene.control.ToggleGroup)

Example 15 with ParameterList

use of qupath.lib.plugins.parameters.ParameterList in project qupath by qupath.

the class GuiTools method promptForSliderRange.

/**
 * Prompt the user to input min/max values for a slider.
 * @param slider
 * @return true if the user may have made changes, false if they cancelled the dialog
 */
public static boolean promptForSliderRange(Slider slider) {
    var params = new ParameterList().addEmptyParameter("Specify the min/max values supported by the slider").addDoubleParameter("minValue", "Slider minimum", slider.getMin()).addDoubleParameter("maxValue", "Slider maximum", slider.getMax());
    if (!Dialogs.showParameterDialog("Slider range", params))
        return false;
    slider.setMin(params.getDoubleParameterValue("minValue"));
    slider.setMax(params.getDoubleParameterValue("maxValue"));
    return true;
}
Also used : ParameterList(qupath.lib.plugins.parameters.ParameterList)

Aggregations

ParameterList (qupath.lib.plugins.parameters.ParameterList)53 BufferedImage (java.awt.image.BufferedImage)15 ArrayList (java.util.ArrayList)13 IOException (java.io.IOException)11 List (java.util.List)9 Collectors (java.util.stream.Collectors)8 BorderPane (javafx.scene.layout.BorderPane)8 PathObject (qupath.lib.objects.PathObject)8 Logger (org.slf4j.Logger)7 LoggerFactory (org.slf4j.LoggerFactory)7 GeneralTools (qupath.lib.common.GeneralTools)7 Dialogs (qupath.lib.gui.dialogs.Dialogs)7 ImageServer (qupath.lib.images.servers.ImageServer)7 Insets (javafx.geometry.Insets)6 Tooltip (javafx.scene.control.Tooltip)6 Collection (java.util.Collection)5 Map (java.util.Map)5 SimpleStringProperty (javafx.beans.property.SimpleStringProperty)5 ContextMenu (javafx.scene.control.ContextMenu)5 Label (javafx.scene.control.Label)5