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Example 1 with InteractionVocabulary

use of org.vcell.pathway.InteractionVocabulary in project vcell by virtualcell.

the class BioPaxObjectPropertiesPanel method refreshInterface.

protected void refreshInterface() {
    if (bioPaxObject == null) {
        // sanity check
        return;
    }
    ArrayList<BioPaxObjectProperty> propertyList = new ArrayList<BioPaxObjectProperty>();
    if (!(bioPaxObject instanceof SBEntity)) {
        tableModel.setData(propertyList);
        return;
    }
    SBEntity sbEntity = (SBEntity) bioPaxObject;
    if (!(sbEntity instanceof Entity)) {
        tableModel.setData(propertyList);
        return;
    }
    Entity entity = (Entity) sbEntity;
    // entity::type
    propertyList.add(new BioPaxObjectProperty("Type", bioPaxObject.getTypeLabel()));
    if (lookupContains(entity)) {
        propertyList.add(new BioPaxObjectProperty("Name", entity.getName().get(0) + " (looking...)"));
    } else if (entity.getFormalNames() != null && entity.getFormalNames().size() != 0) {
        propertyList.add(new BioPaxObjectProperty("Name", entity.getName().get(0) + " (" + entity.getFormalNames().get(0) + ")"));
    } else if (entity.getName() != null && entity.getName().size() > 0) {
        String displayName = entity.getName().get(0);
        if (entity.getxRef() != null && entity.getxRef().size() > 0) {
            displayName = displayName + " (double-click lookup)";
        }
        // entity::name
        propertyList.add(new BioPaxObjectProperty("Name", displayName));
    }
    // entity::Link
    for (RelationshipObject rObject : bioModel.getRelationshipModel().getRelationshipObjects(bioPaxObject)) {
        BioModelEntityObject beObject = rObject.getBioModelEntityObject();
        String sType = beObject.getDisplayType();
        propertyList.add(new BioPaxObjectProperty("Linked physiology object (" + sType + ")", beObject.getName(), beObject));
    }
    if (entity instanceof PhysicalEntity) {
        // ------------------------ PHYSICAL ENTITY -----------------------
        PhysicalEntity physicalEntity = (PhysicalEntity) entity;
        // physicalEntity::feature (***ignored***)
        // physicalEntity::memberPhysicalEntity (***ignored***)
        // physicalEntity::notFeature (***ignored***)
        // TODO:  extract the kinetic law, then the SBEntities, then the measurables, units, aso
        boolean isReactionParticipant = BioPAXUtil.isReactionParticipant(physicalEntity, bioModel.getPathwayModel());
        String role = "";
        if (BioPAXUtil.isController(physicalEntity, bioModel.getPathwayModel())) {
            role += "Controller";
            if (isReactionParticipant) {
                role += ", Participant";
            }
        } else if (isReactionParticipant) {
            role += "Participant";
        }
        if (!role.isEmpty()) {
            propertyList.add(new BioPaxObjectProperty("Role(s)", role));
        }
        if (!(physicalEntity instanceof SmallMolecule)) {
            // physicalEntity::cellular location
            CellularLocationVocabulary cellularLocation = physicalEntity.getCellularLocation();
            if (cellularLocation != null && cellularLocation.getTerm() != null && cellularLocation.getTerm().size() > 0) {
                propertyList.add(new BioPaxObjectProperty("Cellular Location", cellularLocation.getTerm().get(0), cellularLocation));
            } else if (entity.getName() != null && entity.getName().size() > 1) {
                String location = entity.getName().get(1);
                if (location.contains("[") && location.contains("]")) {
                    location = location.substring(location.indexOf("[") + 1, location.indexOf("]"));
                    propertyList.add(new BioPaxObjectProperty("Cellular Location", location));
                }
            }
        }
        if (physicalEntity instanceof Complex) {
            Complex complex = (Complex) physicalEntity;
            // complex::components
            for (PhysicalEntity pe : complex.getComponents()) {
                propertyList.add(new BioPaxObjectProperty("Component", getEntityName(pe), pe));
            }
        } else if (physicalEntity instanceof Protein) {
        // Protein protein = (Protein)entity;
        // protein::entity reference (***ignored***)
        } else if (physicalEntity instanceof SmallMolecule) {
            SmallMolecule sm = (SmallMolecule) physicalEntity;
            EntityReference er = sm.getEntityReference();
            if (er != null && !er.getName().isEmpty() && er.getName().get(0) != null && !er.getName().get(0).isEmpty()) {
                propertyList.add(new BioPaxObjectProperty("Entity Reference", er.getName().get(0)));
                ArrayList<Xref> xrefList = er.getxRef();
                for (Xref xref : xrefList) {
                    propertyList.add(new BioPaxObjectProperty("   Xref", xref.getDb() + ":" + xref.getId(), xref));
                }
            }
        } else if (physicalEntity instanceof Dna) {
        // dna::entityReference (***ignored***)
        } else if (physicalEntity instanceof DnaRegion) {
        // dnaRegion::entityReference (***ignored***)
        } else if (physicalEntity instanceof Rna) {
        // rna::entityReference (***ignored***)
        } else if (physicalEntity instanceof RnaRegion) {
        // rnaRegion::entityReference (***ignored***)
        }
    } else if (entity instanceof Interaction) {
        // --------------------------- INTERACTION -------------------
        Interaction interaction = (Interaction) entity;
        // interaction::interactionType
        for (InteractionVocabulary interactionVocabulary : interaction.getInteractionTypes()) {
            if (interactionVocabulary.getTerm().size() > 0) {
                propertyList.add(new BioPaxObjectProperty("Interaction Type", interactionVocabulary.getTerm().get(0), interactionVocabulary));
            }
        }
        // interaction::participants
        for (InteractionParticipant interactionParticipant : interaction.getParticipants()) {
            PhysicalEntity physicalEntity = interactionParticipant.getPhysicalEntity();
            String physicalEntityName = physicalEntity.getName().size() > 0 ? physicalEntity.getName().get(0) : physicalEntity.getIDShort();
            String cellularLocation = "";
            if (physicalEntity.getCellularLocation() != null) {
                cellularLocation = physicalEntity.getCellularLocation().getTerm().size() > 0 ? " [" + physicalEntity.getCellularLocation().getTerm().get(0) + "]" : "";
            }
            propertyList.add(new BioPaxObjectProperty(interactionParticipant.getLevel3PropertyName(), physicalEntityName + cellularLocation, physicalEntity));
        }
        // get the controllers for interactions
        // we always need this because there's no guarantee we'll have kinetic laws
        // for instance pathway commons doesn't have quantitative information
        Set<String> controllersNames = getControllersNames(interaction);
        if (controllersNames.size() > 0) {
            for (String str : controllersNames) {
                // String tooltip = "<html>how many of these 12 M <br>average size  1.12345*E12 nm <br>temperature 37 degrees Celsius</html>";
                String tooltip = "";
                propertyList.add(new BioPaxObjectProperty("Controlled by", str, interaction, tooltip));
            }
        }
        // get the kinetic laws (if any)
        Set<Control> controls = BioPAXUtil.getControlsOfInteraction(interaction, bioModel.getPathwayModel());
        for (Control control : controls) {
            ArrayList<SBEntity> sbEntities = control.getSBSubEntity();
            for (SBEntity sbE : sbEntities) {
                // the only SBSubEntities allowed in a control are kinetic laws
                if (sbE.getID().contains("kineticLaw")) {
                    String str = new String();
                    if (control.getPhysicalControllers() != null) {
                        str += " for Controller(s): ";
                        for (PhysicalEntity ep : control.getPhysicalControllers()) {
                            if (ep.getName().size() > 0) {
                                str += ep.getName().get(0);
                            } else {
                                str += ep.getIDShort();
                            }
                            str += " ";
                        }
                    }
                    String sDetails = "";
                    ArrayList<SBVocabulary> sbTerms = sbE.getSBTerm();
                    for (SBVocabulary sbv : sbTerms) {
                        // type of kinetic law
                        String str1 = sbv.getID();
                        str1 = str1.substring(str1.lastIndexOf('#') + 1);
                        System.out.println(str1);
                        SBOTerm sboT = SBOListEx.sboMap.get(str1);
                        sDetails += "<font color=\"#660000\"><b>" + sboT.getName() + "</b></font>" + "  " + "<font color=\"#006600\">" + sboT.getDescription() + "</font>";
                        sDetails += "<br>";
                    }
                    ArrayList<SBEntity> klProperties = sbE.getSBSubEntity();
                    for (SBEntity klProperty : klProperties) {
                        if (klProperty instanceof SBMeasurable) {
                            SBMeasurable m = (SBMeasurable) klProperty;
                            String str1 = "";
                            String str2 = "";
                            String str3 = "";
                            if (m.hasTerm()) {
                                str1 += m.extractSBOTermAsString();
                            }
                            if (m.hasNumber()) {
                                str2 += m.getNumber().get(0);
                            }
                            if (m.hasUnit()) {
                                str3 += m.extractSBOUnitAsString();
                            }
                            // str1 is an SBO id, for example "SBO:0000064"
                            SBOTerm sboT = SBOListEx.sboMap.get(str1);
                            sDetails += sboT.getSymbol() + "   (" + sboT.getName() + ")" + "<font color=\"#660000\"><b>" + str2 + str3 + "</b></font>" + "  " + "<font color=\"#006600\">" + sboT.getDescription() + "</font>";
                        } else {
                            sDetails = klProperty.getIDShort() + "  " + klProperty.getTypeLabel();
                        }
                        sDetails += "<br>";
                    }
                    // String tooltip = "<html>how many of these 12 M <br>average size  1.12345*E12 nm <br>temperature 37 degrees Celsius</html>";
                    String tooltip = "";
                    BioPaxObjectProperty bpop = new BioPaxObjectProperty("Kinetic Law" + str, sbE.getID(), sbE, tooltip);
                    bpop.setDetails(sDetails);
                    propertyList.add(bpop);
                }
            }
        }
        if (interaction instanceof Control) {
            // TODO: is this ever being called?
            Control c = (Control) interaction;
            // catalysis::controlled
            Interaction controlledInteraction = c.getControlledInteraction();
            if (controlledInteraction != null) {
                String controlledName = controlledInteraction.getIDShort();
                if (controlledInteraction.getName().size() > 0) {
                    controlledName = controlledInteraction.getName().get(0);
                }
                propertyList.add(new BioPaxObjectProperty("Controlled Interaction", controlledName, controlledInteraction));
            }
        }
    } else if (entity instanceof GroupObject) {
        // ---------------------- GROUP OBJECT ------------------
        GroupObject groupObject = (GroupObject) entity;
        for (BioPaxObject bpo : groupObject.getGroupedObjects()) {
            propertyList.add(new BioPaxObjectProperty("Element::" + bpo.getTypeLabel(), getEntityName((Entity) bpo), bpo));
        }
    }
    // entity::comments
    for (String comment : entity.getComments()) {
        propertyList.add(new BioPaxObjectProperty("Comment", comment));
    }
    // entity::xRef
    ArrayList<Xref> xrefList = ((Entity) bioPaxObject).getxRef();
    for (Xref xref : xrefList) {
        if (xref instanceof UnificationXref) {
            propertyList.add(new BioPaxObjectProperty("Xref", xref.getDb() + ":" + xref.getId(), xref));
        }
    }
    for (Xref xref : xrefList) {
        if (xref instanceof RelationshipXref) {
            propertyList.add(new BioPaxObjectProperty("Xref (related)", xref.getDb() + ":" + xref.getId(), xref));
        }
    }
    for (Xref xref : xrefList) {
        if (xref instanceof PublicationXref) {
            propertyList.add(new BioPaxObjectProperty("Publication", xref.getDb() + ":" + xref.getId(), xref));
        }
    }
    // for(SBVocabulary sbVocab : sbEntity.getSBTerm()) {
    // propertyList.add(new BioPaxObjectProperty("SBO Term", SBPAXLabelUtil.makeLabel(sbVocab)));
    // }
    // if(sbEntity instanceof Interaction) {
    // // TODO: this goes away
    // Interaction interaction = (Interaction) sbEntity;
    // Set<SBEntity> subEntities = new HashSet<SBEntity>();
    // subEntities.add(interaction);
    // Set<Control> controls = BioPAXUtil.findAllControls(interaction, bioModel.getPathwayModel());
    // subEntities.addAll(controls);
    // subEntities = SBPAX3Util.extractAllEntities(subEntities);
    // for(SBEntity subEntity : subEntities) {
    // if(subEntity instanceof SBMeasurable) {
    // propertyList.add(new BioPaxObjectProperty("Measured quantity", SBPAXLabelUtil.makeLabel(subEntity)));
    // }
    // }
    // }
    tableModel.setData(propertyList);
}
Also used : SBVocabulary(org.vcell.pathway.sbpax.SBVocabulary) SBEntity(org.vcell.pathway.sbpax.SBEntity) PhysicalEntity(org.vcell.pathway.PhysicalEntity) Entity(org.vcell.pathway.Entity) Set(java.util.Set) TreeSet(java.util.TreeSet) HashSet(java.util.HashSet) Rna(org.vcell.pathway.Rna) PublicationXref(org.vcell.pathway.PublicationXref) InteractionVocabulary(org.vcell.pathway.InteractionVocabulary) BioPaxObject(org.vcell.pathway.BioPaxObject) ArrayList(java.util.ArrayList) CellularLocationVocabulary(org.vcell.pathway.CellularLocationVocabulary) SBEntity(org.vcell.pathway.sbpax.SBEntity) RelationshipObject(org.vcell.relationship.RelationshipObject) Complex(org.vcell.pathway.Complex) RnaRegion(org.vcell.pathway.RnaRegion) SBMeasurable(org.vcell.pathway.sbpax.SBMeasurable) Xref(org.vcell.pathway.Xref) UnificationXref(org.vcell.pathway.UnificationXref) RelationshipXref(org.vcell.pathway.RelationshipXref) PublicationXref(org.vcell.pathway.PublicationXref) Control(org.vcell.pathway.Control) DnaRegion(org.vcell.pathway.DnaRegion) EntityReference(org.vcell.pathway.EntityReference) Interaction(org.vcell.pathway.Interaction) UnificationXref(org.vcell.pathway.UnificationXref) GroupObject(org.vcell.pathway.GroupObject) SBOTerm(org.vcell.pathway.sbo.SBOTerm) BioModelEntityObject(cbit.vcell.model.BioModelEntityObject) Protein(org.vcell.pathway.Protein) RelationshipXref(org.vcell.pathway.RelationshipXref) PhysicalEntity(org.vcell.pathway.PhysicalEntity) SmallMolecule(org.vcell.pathway.SmallMolecule) Dna(org.vcell.pathway.Dna) InteractionParticipant(org.vcell.pathway.InteractionParticipant)

Example 2 with InteractionVocabulary

use of org.vcell.pathway.InteractionVocabulary in project vcell by virtualcell.

the class PathwayReader method addObjectInteractionVocabulary.

private InteractionVocabulary addObjectInteractionVocabulary(Element element) {
    InteractionVocabulary interactionVocabulary = new InteractionVocabulary();
    addAttributes(interactionVocabulary, element);
    for (Object child : element.getChildren()) {
        if (child instanceof Element) {
            Element childElement = (Element) child;
            if (!addContentControlledVocabulary(interactionVocabulary, element, childElement)) {
                showUnexpected(childElement, interactionVocabulary);
            }
        }
    }
    pathwayModel.add(interactionVocabulary);
    return interactionVocabulary;
}
Also used : InteractionVocabulary(org.vcell.pathway.InteractionVocabulary) Element(org.jdom.Element) BioPaxObject(org.vcell.pathway.BioPaxObject)

Example 3 with InteractionVocabulary

use of org.vcell.pathway.InteractionVocabulary in project vcell by virtualcell.

the class PathwayProducerBiopax3 method addContentInteraction.

// interactionType InteractionVocabulary 	multiple
// participant 	Entity 					multiple
private Element addContentInteraction(BioPaxObject bpObject, Element element) {
    element = addContentEntity(bpObject, element);
    Interaction ob = (Interaction) bpObject;
    Element tmpElement = null;
    if (ob.getInteractionTypes() != null && ob.getInteractionTypes().size() > 0) {
        List<InteractionVocabulary> list = ob.getInteractionTypes();
        for (InteractionVocabulary item : list) {
            tmpElement = new Element("interactionType", bp);
            addIDToProperty(tmpElement, item);
            mustPrintObject(item);
            element.addContent(tmpElement);
        }
    }
    if (ob.getParticipants(InteractionParticipant.Type.PARTICIPANT) != null && ob.getParticipants(InteractionParticipant.Type.PARTICIPANT).size() > 0) {
        List<InteractionParticipant> list = ob.getParticipants(InteractionParticipant.Type.PARTICIPANT);
        for (InteractionParticipant item : list) {
            tmpElement = new Element("participant", bp);
            // tmpElement.setAttribute("resource", getResource(item), rdf);
            // mustPrintObject(item);
            addIDToProperty(tmpElement, item.getPhysicalEntity());
            mustPrintObject(item.getPhysicalEntity());
            element.addContent(tmpElement);
        }
    }
    return element;
}
Also used : Interaction(org.vcell.pathway.Interaction) MolecularInteraction(org.vcell.pathway.MolecularInteraction) GeneticInteraction(org.vcell.pathway.GeneticInteraction) InteractionVocabulary(org.vcell.pathway.InteractionVocabulary) Element(org.jdom.Element) InteractionParticipant(org.vcell.pathway.InteractionParticipant)

Example 4 with InteractionVocabulary

use of org.vcell.pathway.InteractionVocabulary in project vcell by virtualcell.

the class PathwayReaderBiopax3 method addObjectInteractionVocabulary.

private InteractionVocabulary addObjectInteractionVocabulary(Element element) {
    if (element.getChildren().size() == 0) {
        InteractionVocabularyProxy proxy = new InteractionVocabularyProxy();
        addAttributes(proxy, element);
        pathwayModel.add(proxy);
        return proxy;
    }
    InteractionVocabulary interactionVocabulary = new InteractionVocabulary();
    addAttributes(interactionVocabulary, element);
    for (Object child : element.getChildren()) {
        if (child instanceof Element) {
            Element childElement = (Element) child;
            if (!addContentControlledVocabulary(interactionVocabulary, element, childElement)) {
                showUnexpected(childElement);
            }
        }
    }
    pathwayModel.add(interactionVocabulary);
    return interactionVocabulary;
}
Also used : InteractionVocabulary(org.vcell.pathway.InteractionVocabulary) Element(org.jdom.Element) GroupObject(org.vcell.pathway.GroupObject) BioPaxObject(org.vcell.pathway.BioPaxObject) InteractionVocabularyProxy(org.vcell.pathway.persistence.BiopaxProxy.InteractionVocabularyProxy)

Aggregations

InteractionVocabulary (org.vcell.pathway.InteractionVocabulary)4 Element (org.jdom.Element)3 BioPaxObject (org.vcell.pathway.BioPaxObject)3 GroupObject (org.vcell.pathway.GroupObject)2 Interaction (org.vcell.pathway.Interaction)2 InteractionParticipant (org.vcell.pathway.InteractionParticipant)2 BioModelEntityObject (cbit.vcell.model.BioModelEntityObject)1 ArrayList (java.util.ArrayList)1 HashSet (java.util.HashSet)1 Set (java.util.Set)1 TreeSet (java.util.TreeSet)1 CellularLocationVocabulary (org.vcell.pathway.CellularLocationVocabulary)1 Complex (org.vcell.pathway.Complex)1 Control (org.vcell.pathway.Control)1 Dna (org.vcell.pathway.Dna)1 DnaRegion (org.vcell.pathway.DnaRegion)1 Entity (org.vcell.pathway.Entity)1 EntityReference (org.vcell.pathway.EntityReference)1 GeneticInteraction (org.vcell.pathway.GeneticInteraction)1 MolecularInteraction (org.vcell.pathway.MolecularInteraction)1