use of dr.evomodel.substmodel.FrequencyModel in project beast-mcmc by beast-dev.
the class DataLikelihoodTester method main.
public static void main(String[] args) {
// turn off logging to avoid screen noise...
Logger logger = Logger.getLogger("dr");
logger.setUseParentHandlers(false);
SimpleAlignment alignment = createAlignment(sequences, Nucleotides.INSTANCE);
TreeModel treeModel;
try {
treeModel = createSpecifiedTree("((human:0.1,chimp:0.1):0.1,gorilla:0.2)");
} catch (Exception e) {
throw new RuntimeException("Unable to parse Newick tree");
}
System.out.print("\nTest BeagleTreeLikelihood (kappa = 1): ");
//substitutionModel
Parameter freqs = new Parameter.Default(new double[] { 0.25, 0.25, 0.25, 0.25 });
Parameter kappa = new Parameter.Default(HKYParser.KAPPA, 1.0, 0, 100);
FrequencyModel f = new FrequencyModel(Nucleotides.INSTANCE, freqs);
HKY hky = new HKY(kappa, f);
//siteModel
double alpha = 0.5;
GammaSiteRateModel siteRateModel = new GammaSiteRateModel("gammaModel", alpha, 4);
// GammaSiteRateModel siteRateModel = new GammaSiteRateModel("siteRateModel");
siteRateModel.setSubstitutionModel(hky);
Parameter mu = new Parameter.Default(GammaSiteModelParser.SUBSTITUTION_RATE, 1.0, 0, Double.POSITIVE_INFINITY);
siteRateModel.setRelativeRateParameter(mu);
FrequencyModel f2 = new FrequencyModel(Nucleotides.INSTANCE, freqs);
Parameter kappa2 = new Parameter.Default(HKYParser.KAPPA, 10.0, 0, 100);
HKY hky2 = new HKY(kappa2, f2);
GammaSiteRateModel siteRateModel2 = new GammaSiteRateModel("gammaModel", alpha, 4);
siteRateModel2.setSubstitutionModel(hky2);
siteRateModel2.setRelativeRateParameter(mu);
//treeLikelihood
SitePatterns patterns = new SitePatterns(alignment, null, 0, -1, 1, true);
BranchModel branchModel = new HomogeneousBranchModel(siteRateModel.getSubstitutionModel(), siteRateModel.getSubstitutionModel().getFrequencyModel());
BranchModel branchModel2 = new HomogeneousBranchModel(siteRateModel2.getSubstitutionModel(), siteRateModel2.getSubstitutionModel().getFrequencyModel());
BranchRateModel branchRateModel = new DefaultBranchRateModel();
BeagleTreeLikelihood treeLikelihood = new BeagleTreeLikelihood(patterns, treeModel, branchModel, siteRateModel, branchRateModel, null, false, PartialsRescalingScheme.AUTO, true);
double logLikelihood = treeLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("\nTest BeagleDataLikelihoodDelegate (kappa = 1): ");
BeagleDataLikelihoodDelegate dataLikelihoodDelegate = new BeagleDataLikelihoodDelegate(treeModel, patterns, branchModel, siteRateModel, false, PartialsRescalingScheme.NONE, false);
TreeDataLikelihood treeDataLikelihood = new TreeDataLikelihood(dataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(5.0);
System.out.print("\nTest BeagleDataLikelihoodDelegate (kappa = 5): ");
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("\nTest BeagleDataLikelihoodDelegate (kappa = 10): ");
dataLikelihoodDelegate = new BeagleDataLikelihoodDelegate(treeModel, patterns, branchModel2, siteRateModel2, false, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(dataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
hky2.setKappa(11.0);
System.out.print("\nTest BeagleDataLikelihoodDelegate (kappa = 11): ");
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(1.0);
hky2.setKappa(10.0);
MultiPartitionDataLikelihoodDelegate multiPartitionDataLikelihoodDelegate;
System.out.print("\nTest MultiPartitionDataLikelihoodDelegate 1 partition (kappa = 1):");
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, Collections.singletonList((PatternList) patterns), Collections.singletonList((BranchModel) branchModel), Collections.singletonList((SiteRateModel) siteRateModel), true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(5.0);
System.out.print("\nTest MultiPartitionDataLikelihoodDelegate 1 partition (kappa = 5):");
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(1.0);
System.out.print("\nTest MultiPartitionDataLikelihoodDelegate 1 partition (kappa = 10):");
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, Collections.singletonList((PatternList) patterns), Collections.singletonList((BranchModel) branchModel2), Collections.singletonList((SiteRateModel) siteRateModel2), true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("\nTest MultiPartitionDataLikelihoodDelegate 2 partitions (kappa = 1, 10): ");
List<PatternList> patternLists = new ArrayList<PatternList>();
patternLists.add(patterns);
patternLists.add(patterns);
List<SiteRateModel> siteRateModels = new ArrayList<SiteRateModel>();
siteRateModels.add(siteRateModel);
siteRateModels.add(siteRateModel2);
List<BranchModel> branchModels = new ArrayList<BranchModel>();
branchModels.add(branchModel);
branchModels.add(branchModel2);
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, patternLists, branchModels, siteRateModels, true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: this is 2x the logLikelihood of the 2nd partition)\n\n");
System.exit(0);
//START ADDITIONAL TEST #1 - Guy Baele
System.out.println("-- Test #1 SiteRateModels -- ");
//alpha in partition 1 reject followed by alpha in partition 2 reject
System.out.print("Adjust alpha in partition 1: ");
siteRateModel.setAlpha(0.4);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("Return alpha in partition 1 to original value: ");
siteRateModel.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (i.e. reject: OK)\n");
System.out.print("Adjust alpha in partition 2: ");
siteRateModel2.setAlpha(0.35);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("Return alpha in partition 2 to original value: ");
siteRateModel2.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (i.e. reject: OK)\n");
//alpha in partition 1 accept followed by alpha in partition 2 accept
System.out.print("Adjust alpha in partition 1: ");
siteRateModel.setAlpha(0.4);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("Adjust alpha in partition 2: ");
siteRateModel2.setAlpha(0.35);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: same logLikelihood as only setting alpha in partition 2)");
System.out.print("Return alpha in partition 1 to original value: ");
siteRateModel.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: alpha in partition 2 has not been returned to original value yet)");
System.out.print("Return alpha in partition 2 to original value: ");
siteRateModel2.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n");
//adjusting alphas in both partitions without explicitly calling getLogLikelihood() in between
System.out.print("Adjust both alphas in partitions 1 and 2: ");
siteRateModel.setAlpha(0.4);
siteRateModel2.setAlpha(0.35);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("Return alpha in partition 2 to original value: ");
siteRateModel2.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: alpha in partition 1 has not been returned to original value yet)");
System.out.print("Return alpha in partition 1 to original value: ");
siteRateModel.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n\n");
//END ADDITIONAL TEST - Guy Baele
//START ADDITIONAL TEST #2 - Guy Baele
System.out.println("-- Test #2 SiteRateModels -- ");
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
//1 siteRateModel shared across 2 partitions
siteRateModels = new ArrayList<SiteRateModel>();
siteRateModels.add(siteRateModel);
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, patternLists, branchModels, siteRateModels, true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n");
System.out.print("Adjust alpha in shared siteRateModel: ");
siteRateModel.setAlpha(0.4);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: same logLikelihood as only adjusted alpha for partition 1)");
siteRateModel.setAlpha(0.5);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n\n");
//END ADDITIONAL TEST - Guy Baele
//START ADDITIONAL TEST #3 - Guy Baele
System.out.println("-- Test #3 SiteRateModels -- ");
siteRateModel = new GammaSiteRateModel("gammaModel");
siteRateModel.setSubstitutionModel(hky);
siteRateModel.setRelativeRateParameter(mu);
siteRateModel2 = new GammaSiteRateModel("gammaModel2");
siteRateModel2.setSubstitutionModel(hky2);
siteRateModel2.setRelativeRateParameter(mu);
siteRateModels = new ArrayList<SiteRateModel>();
siteRateModels.add(siteRateModel);
siteRateModels.add(siteRateModel2);
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, patternLists, branchModels, siteRateModels, true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n");
System.out.print("Adjust kappa in partition 1: ");
hky.setKappa(5.0);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: logLikelihood has not changed?)");
System.out.print("Return kappa in partition 1 to original value: ");
hky.setKappa(1.0);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + "\n");
System.out.print("Adjust kappa in partition 2: ");
hky2.setKappa(11.0);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood);
System.out.print("Return kappa in partition 2 to original value: ");
hky2.setKappa(10.0);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.println("logLikelihood = " + logLikelihood + " (i.e. reject: OK)\n\n");
//END ADDITIONAL TEST - Guy Baele
//START ADDITIONAL TEST #4 - Guy Baele
System.out.println("-- Test #4 SiteRateModels -- ");
SimpleAlignment secondAlignment = createAlignment(moreSequences, Nucleotides.INSTANCE);
SitePatterns morePatterns = new SitePatterns(secondAlignment, null, 0, -1, 1, true);
BeagleDataLikelihoodDelegate dataLikelihoodDelegateOne = new BeagleDataLikelihoodDelegate(treeModel, patterns, branchModel, siteRateModel, false, PartialsRescalingScheme.NONE, false);
TreeDataLikelihood treeDataLikelihoodOne = new TreeDataLikelihood(dataLikelihoodDelegateOne, treeModel, branchRateModel);
logLikelihood = treeDataLikelihoodOne.getLogLikelihood();
System.out.println("\nBeagleDataLikelihoodDelegate logLikelihood partition 1 (kappa = 1) = " + logLikelihood);
hky.setKappa(10.0);
logLikelihood = treeDataLikelihoodOne.getLogLikelihood();
System.out.println("BeagleDataLikelihoodDelegate logLikelihood partition 1 (kappa = 10) = " + logLikelihood);
hky.setKappa(1.0);
BeagleDataLikelihoodDelegate dataLikelihoodDelegateTwo = new BeagleDataLikelihoodDelegate(treeModel, morePatterns, branchModel2, siteRateModel2, false, PartialsRescalingScheme.NONE, false);
TreeDataLikelihood treeDataLikelihoodTwo = new TreeDataLikelihood(dataLikelihoodDelegateTwo, treeModel, branchRateModel);
logLikelihood = treeDataLikelihoodTwo.getLogLikelihood();
System.out.println("BeagleDataLikelihoodDelegate logLikelihood partition 2 (kappa = 10) = " + logLikelihood + "\n");
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, Collections.singletonList((PatternList) patterns), Collections.singletonList((BranchModel) branchModel), Collections.singletonList((SiteRateModel) siteRateModel), true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.print("Test MultiPartitionDataLikelihoodDelegate 1st partition (kappa = 1):");
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(10.0);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.print("Test MultiPartitionDataLikelihoodDelegate 1st partition (kappa = 10):");
System.out.println("logLikelihood = " + logLikelihood);
hky.setKappa(1.0);
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, Collections.singletonList((PatternList) morePatterns), Collections.singletonList((BranchModel) branchModel2), Collections.singletonList((SiteRateModel) siteRateModel2), true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.print("Test MultiPartitionDataLikelihoodDelegate 2nd partition (kappa = 10):");
System.out.println("logLikelihood = " + logLikelihood + "\n");
patternLists = new ArrayList<PatternList>();
patternLists.add(patterns);
patternLists.add(morePatterns);
multiPartitionDataLikelihoodDelegate = new MultiPartitionDataLikelihoodDelegate(treeModel, patternLists, branchModels, siteRateModels, true, PartialsRescalingScheme.NONE, false);
treeDataLikelihood = new TreeDataLikelihood(multiPartitionDataLikelihoodDelegate, treeModel, branchRateModel);
logLikelihood = treeDataLikelihood.getLogLikelihood();
System.out.print("Test MultiPartitionDataLikelihoodDelegate 2 partitions (kappa = 1, 10): ");
System.out.println("logLikelihood = " + logLikelihood + " (NOT OK: should be the sum of both separate logLikelihoods)\nKappa value of partition 2 is used to compute logLikelihood for both partitions?");
//END ADDITIONAL TEST - Guy Baele
}
use of dr.evomodel.substmodel.FrequencyModel in project beast-mcmc by beast-dev.
the class HKY method main.
public static void main(String[] args) {
// double kappa = 2.0;
// double[] pi = new double[]{0.15,0.30,0.20,0.35};
// double time = 0.1;
double kappa = 1.0;
double[] pi = new double[] { 0.25, 0.25, 0.25, 0.25 };
double time = 0.1;
FrequencyModel freqModel = new FrequencyModel(Nucleotides.INSTANCE, pi);
HKY hky = new HKY(kappa, freqModel);
EigenDecomposition decomp = hky.getEigenDecomposition();
// Matrix evec = new Matrix(decomp.getEigenVectors());
// Matrix ivec = new Matrix(decomp.getInverseEigenVectors());
// System.out.println("Evec =\n"+evec);
// System.out.println("Ivec =\n"+ivec);
Vector eval = new Vector(decomp.getEigenValues());
System.out.println("Eval = " + eval);
double[] probs = new double[16];
hky.getTransitionProbabilities(time, probs);
System.out.println("new probs = " + new Vector(probs));
// check against old implementation
dr.oldevomodel.substmodel.FrequencyModel oldFreq = new dr.oldevomodel.substmodel.FrequencyModel(Nucleotides.INSTANCE, pi);
dr.oldevomodel.substmodel.HKY oldHKY = new dr.oldevomodel.substmodel.HKY(kappa, oldFreq);
oldHKY.setKappa(kappa);
oldHKY.getTransitionProbabilities(time, probs);
System.out.println("old probs = " + new Vector(probs));
}
use of dr.evomodel.substmodel.FrequencyModel in project beast-mcmc by beast-dev.
the class PCACodonModelParser method parseXMLObject.
public Object parseXMLObject(XMLObject xo) throws XMLParseException {
Codons codons = Codons.UNIVERSAL;
if (xo.hasAttribute(GeneticCode.GENETIC_CODE)) {
String codeStr = xo.getStringAttribute(GeneticCode.GENETIC_CODE);
if (codeStr.equals(GeneticCode.UNIVERSAL.getName())) {
codons = Codons.UNIVERSAL;
} else if (codeStr.equals(GeneticCode.VERTEBRATE_MT.getName())) {
codons = Codons.VERTEBRATE_MT;
} else if (codeStr.equals(GeneticCode.YEAST.getName())) {
codons = Codons.YEAST;
} else if (codeStr.equals(GeneticCode.MOLD_PROTOZOAN_MT.getName())) {
codons = Codons.MOLD_PROTOZOAN_MT;
} else if (codeStr.equals(GeneticCode.INVERTEBRATE_MT.getName())) {
codons = Codons.INVERTEBRATE_MT;
} else if (codeStr.equals(GeneticCode.CILIATE.getName())) {
codons = Codons.CILIATE;
} else if (codeStr.equals(GeneticCode.ECHINODERM_MT.getName())) {
codons = Codons.ECHINODERM_MT;
} else if (codeStr.equals(GeneticCode.EUPLOTID_NUC.getName())) {
codons = Codons.EUPLOTID_NUC;
} else if (codeStr.equals(GeneticCode.BACTERIAL.getName())) {
codons = Codons.BACTERIAL;
} else if (codeStr.equals(GeneticCode.ALT_YEAST.getName())) {
codons = Codons.ALT_YEAST;
} else if (codeStr.equals(GeneticCode.ASCIDIAN_MT.getName())) {
codons = Codons.ASCIDIAN_MT;
} else if (codeStr.equals(GeneticCode.FLATWORM_MT.getName())) {
codons = Codons.FLATWORM_MT;
} else if (codeStr.equals(GeneticCode.BLEPHARISMA_NUC.getName())) {
codons = Codons.BLEPHARISMA_NUC;
} else if (codeStr.equals(GeneticCode.NO_STOPS.getName())) {
codons = Codons.NO_STOPS;
}
}
// get number of PCs
Parameter pcaDimensionParameter = (Parameter) xo.getElementFirstChild(PCA_DIMENSION);
// get directory with pca rate matrix files; fallback to default "pcadata"
String dirString = "pcadata";
if (xo.hasAttribute(PCA_DATA_DIR)) {
dirString = xo.getStringAttribute(PCA_DATA_DIR);
}
// get type of rate matrix; fallback to mammalia pca
AbstractPCARateMatrix pcaType = new PCARateMatrixMammalia(pcaDimensionParameter.getDimension(), dirString);
// check for other type of pca
if (xo.hasAttribute(PCATYPE)) {
String pcaTypeString = xo.getStringAttribute(PCATYPE);
if (pcaTypeString.equals(PCARateMatrixMammalia.getName())) {
pcaType = new PCARateMatrixMammalia(pcaDimensionParameter.getDimension(), dirString);
}
}
// decide if getting frequencies from csv or estimating from MSA
FrequencyModel freqModel = null;
if (xo.getChild(FrequencyModel.class) != null) {
freqModel = (FrequencyModel) xo.getChild(FrequencyModel.class);
} else {
freqModel = createNewFreqModel(codons, pcaType);
}
return new PCACodonModel(codons, pcaType, pcaDimensionParameter, freqModel);
}
use of dr.evomodel.substmodel.FrequencyModel in project beast-mcmc by beast-dev.
the class TN93Parser method parseXMLObject.
public Object parseXMLObject(XMLObject xo) throws XMLParseException {
Parameter kappa1Param = (Parameter) xo.getElementFirstChild(KAPPA1);
Parameter kappa2Param = (Parameter) xo.getElementFirstChild(KAPPA2);
FrequencyModel freqModel = (FrequencyModel) xo.getElementFirstChild(FREQUENCIES);
Logger.getLogger("dr.evomodel").info("\nCreating TN93 substitution model. Initial kappa = " + kappa1Param.getValue(0) + "," + kappa2Param.getValue(0));
return new TN93(kappa1Param, kappa2Param, freqModel);
}
use of dr.evomodel.substmodel.FrequencyModel in project beast-mcmc by beast-dev.
the class BinarySubstitutionModelParser method parseXMLObject.
public Object parseXMLObject(XMLObject xo) throws XMLParseException {
Parameter ratesParameter;
XMLObject cxo = xo.getChild(dr.oldevomodelxml.substmodel.GeneralSubstitutionModelParser.FREQUENCIES);
FrequencyModel freqModel = (FrequencyModel) cxo.getChild(FrequencyModel.class);
DataType dataType = freqModel.getDataType();
if (dataType != TwoStates.INSTANCE)
throw new XMLParseException("Frequency model must have binary (two state) data type.");
int relativeTo = 0;
ratesParameter = new Parameter.Default(0);
return new GeneralSubstitutionModel(getParserName(), dataType, freqModel, ratesParameter, relativeTo);
}
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