Examples with Conversion org.vcell.pathway.Conversion used on opensource projects

Example 1 with Conversion

use of org.vcell.pathway.Conversion in project vcell by virtualcell.

the class PathwayMapping method createReactionStepFromPathway.

/*
	 * for reaction:
	 * 1. annotate the selected vcell object using linked pathway conversion
	 * 2. add non-existing speciesContexts from linked pathway conversion
	 * 3. add links between relative vcell objects and pathway objects
	 * Questions:
	 * - how to deal with the case that the reaction is existing in the model?
	 * 		+ add it in no matter what? 
	 * 				(this is the version we have now: 
	 * 					add the duplicated reactions in without name changing, 
	 * 				 	all duplicated reactions share the same participant objects)
	 *      + just modify the existing one?
	 */
private void createReactionStepFromPathway(BioModel bioModel, Process process, ReactionStep reactionStep, RelationshipObject relationshipObject, boolean addSubunits) throws Exception {
    // annotate the selected vcell object using linked pathway object
    // add non-existing speciesContexts from linked pathway conversion
    ReactionParticipant[] rpArray = parseReaction(reactionStep, bioModel, relationshipObject);
    // create a hashtable for interaction Participants
    Hashtable<String, BioPaxObject> participantTable = new Hashtable<String, BioPaxObject>();
    for (BioPaxObject bpObject : ((Conversion) relationshipObject.getBioPaxObject()).getLeft()) {
        if (((PhysicalEntity) bpObject).getName().size() == 0) {
            participantTable.put(getSafetyName(((PhysicalEntity) bpObject).getID()), bpObject);
        } else {
            participantTable.put(getSafetyName(((PhysicalEntity) bpObject).getName().get(0)), bpObject);
        }
    }
    for (BioPaxObject bpObject : ((Conversion) relationshipObject.getBioPaxObject()).getRight()) {
        if (((PhysicalEntity) bpObject).getName().size() == 0) {
            participantTable.put(getSafetyName(((PhysicalEntity) bpObject).getID()), bpObject);
        } else {
            participantTable.put(getSafetyName(((PhysicalEntity) bpObject).getName().get(0)), bpObject);
        }
    }
    for (ReactionParticipant rp : rpArray) {
        SpeciesContext speciesContext = rp.getSpeciesContext();
        if (bioModel.getModel().getSpeciesContext(speciesContext.getName()) == null) {
            // if the speciesContext is not existed, then add it to the bioModel and link it to the corresponding pathway object
            if (bioModel.getModel().getSpecies(speciesContext.getName()) == null) {
                bioModel.getModel().addSpecies(speciesContext.getSpecies());
            }
            bioModel.getModel().addSpeciesContext(speciesContext);
            RelationshipObject newSpeciesContext = new RelationshipObject(speciesContext, participantTable.get(speciesContext.getName()));
            bioModel.getRelationshipModel().addRelationshipObject(newSpeciesContext);
        } else {
            // if it is in the bioModel, then check whether it links to pathway object or not
            HashSet<RelationshipObject> linkedReObjects = bioModel.getRelationshipModel().getRelationshipObjects(bioModel.getModel().getSpeciesContext(speciesContext.getName()));
            if (linkedReObjects != null) {
                boolean isLinked = false;
                for (RelationshipObject reObject : linkedReObjects) {
                    if (reObject.getBioPaxObject() == participantTable.get(speciesContext.getName())) {
                        isLinked = true;
                        break;
                    }
                }
                if (!isLinked) {
                    RelationshipObject newSpeciesContext = new RelationshipObject(speciesContext, participantTable.get(speciesContext.getName()));
                    bioModel.getRelationshipModel().addRelationshipObject(newSpeciesContext);
                }
            } else {
                RelationshipObject newSpeciesContext = new RelationshipObject(speciesContext, participantTable.get(speciesContext.getName()));
                bioModel.getRelationshipModel().addRelationshipObject(newSpeciesContext);
            }
        }
    }
    (reactionStep).setReactionParticipants(rpArray);
    // add Control to the reaction
    if (process.getControl() != null) {
        for (InteractionParticipant pe : process.getControl().getParticipants()) {
            SpeciesContext newSpeciescontext = createSpeciesContextFromBioPaxObject(bioModel, pe.getPhysicalEntity(), addSubunits);
            (reactionStep).addReactionParticipant(new Catalyst(null, reactionStep, newSpeciescontext));
        }
    }
    addKinetics(reactionStep, process);
}

Example 2 with Conversion

use of org.vcell.pathway.Conversion in project vcell by virtualcell.

the class BioModelEditorPathwayDiagramPanel method importIntoModel.

public void importIntoModel() {
    if (bioModel == null) {
        return;
    }
    String warningMessage = "";
    String warningMessage2 = "";
    int warningCount = 0;
    int warningCount2 = 0;
    String infoMessage = "";
    ArrayList<BioPaxObject> importedBPObjects = new ArrayList<BioPaxObject>();
    warningMessage = "The following pathway object(s) have been associated with object(s) in the physiology model:\n";
    warningMessage2 = "The following transport reaction(s) will NOT be converted to the physiology model:\n";
    warningCount = 0;
    warningCount2 = 0;
    infoMessage = "The following pathway object(s) have been coverted in the physiology model:\n\n";
    boolean hasMembrane = false;
    if (bioModel.getModel().getMembranes().size() > 0)
        hasMembrane = true;
    HashSet<BioPaxObject> selected = new HashSet<BioPaxObject>();
    // convert group Object to regular biopaxObjects
    for (BioPaxObject bpo : getSelectedBioPaxObjects()) {
        if (bpo instanceof GroupObject) {
            selected.addAll(((GroupObject) bpo).computeGroupedBioPaxObjects());
        } else {
            selected.add(bpo);
        }
    }
    for (BioPaxObject bpo : selected) {
        if (bpo instanceof Conversion) {
            if (bpo instanceof Transport && !hasMembrane) {
                warningCount2++;
                if (((Conversion) bpo).getName().size() > 0)
                    warningMessage2 += "\nTransport: \'" + ((Conversion) bpo).getName().get(0) + "\'\n";
                else
                    warningMessage2 += "\nTransport: \'" + ((Conversion) bpo).getIDShort() + "\'\n";
            } else if (bioModel.getRelationshipModel().getRelationshipObjects(bpo).size() == 0) {
                importedBPObjects.add(bpo);
            } else {
                warningCount++;
                if (((Conversion) bpo).getName().size() > 0)
                    warningMessage += "\nReaction: \'" + ((Conversion) bpo).getName().get(0) + "\' =>\n";
                else
                    warningMessage += "\nReaction: \'" + ((Conversion) bpo).getIDShort() + "\' =>\n";
                for (RelationshipObject r : bioModel.getRelationshipModel().getRelationshipObjects(bpo)) {
                    warningMessage += "\t=> \'" + r.getBioModelEntityObject().getName() + "\'\n";
                }
            }
        } else if (bpo instanceof PhysicalEntity) {
            if (bioModel.getRelationshipModel().getRelationshipObjects(bpo).size() == 0) {
                importedBPObjects.add(bpo);
            } else {
                warningCount++;
                if (((PhysicalEntity) bpo).getName().size() > 0)
                    warningMessage += "\nSpecies: \'" + ((PhysicalEntity) bpo).getName().get(0) + "\' =>\n";
                else
                    warningMessage += "\nSpecies: \'" + ((PhysicalEntity) bpo).getIDShort() + "\' =>\n";
                for (RelationshipObject r : bioModel.getRelationshipModel().getRelationshipObjects(bpo)) {
                    warningMessage += "\t=> \'" + r.getBioModelEntityObject().getName() + "\'\n";
                }
            }
        }
    }
    // create import panel
    conversionPanel = new ConversionPanel();
    conversionPanel.setBioModel(bioModel);
    conversionPanel.setSelectionManager(getSelectionManager());
    // show warning message
    warningMessage2 += "\nNO membrane structures available in the physiology model.\n";
    if (warningCount2 > 0) {
        DialogUtils.showWarningDialog(conversionPanel, warningMessage2);
    }
    warningMessage += "\nThey will NOT be converted to the physiology model.\n";
    if (warningCount > 0) {
        DialogUtils.showWarningDialog(conversionPanel, warningMessage);
    }
    if (importedBPObjects.size() == 0) {
        return;
    }
    // set the selected objects to be the validly imported biopaxObject set
    conversionPanel.setBioPaxObjects(importedBPObjects);
    int returnCode = DialogUtils.showComponentOKCancelDialog(this, conversionPanel, "Import into Physiology");
    if (returnCode == JOptionPane.OK_OPTION) {
        PathwayMapping pathwayMapping = new PathwayMapping();
        try {
            // function I:
            // pass the table rows that contains user edited values to create Vcell object
            pathwayMapping.createBioModelEntitiesFromBioPaxObjects(bioModel, conversionPanel.getTableRows(), conversionPanel.isAddSubunits());
            for (BioPaxObject bpo : importedBPObjects) {
                if (bpo instanceof Conversion) {
                    infoMessage += "Reaction: \t\'";
                    for (RelationshipObject r : bioModel.getRelationshipModel().getRelationshipObjects(bpo)) {
                        infoMessage += r.getBioModelEntityObject().getName() + "\'\n";
                    }
                    infoMessage += "\n";
                } else if (bpo instanceof PhysicalEntity) {
                    infoMessage += "Species: \t\'";
                    for (RelationshipObject r : bioModel.getRelationshipModel().getRelationshipObjects(bpo)) {
                        infoMessage += r.getBioModelEntityObject().getName() + "\'\n";
                    }
                    infoMessage += "\n";
                }
            }
            DialogUtils.showInfoDialog(this, infoMessage);
            // jump the view to reaction diagram panel
            if (selectionManager != null) {
                selectionManager.setActiveView(new ActiveView(null, DocumentEditorTreeFolderClass.REACTION_DIAGRAM_NODE, ActiveViewID.reaction_diagram));
            }
        } catch (Exception e) {
            e.printStackTrace(System.out);
            DialogUtils.showErrorDialog(this, "Errors occur when converting pathway objects to VCell bioModel objects.\n" + e.getMessage());
        }
    }
}

Example 3 with Conversion

use of org.vcell.pathway.Conversion in project vcell by virtualcell.

the class BioPaxRelationshipTableModel method refreshData.

private void refreshData() {
    ArrayList<BioPaxRelationshipTableRow> entityRows = new ArrayList<BioPaxRelationshipTableRow>();
    if (bioModel != null) {
        HashSet<RelationshipObject> relationshipObjects = null;
        if (bioPaxObject != null) {
            relationshipObjects = bioModel.getRelationshipModel().getRelationshipObjects(bioPaxObject);
        }
        List<BioPaxRelationshipTableRow> allEntityRows = new ArrayList<BioPaxRelationshipTableRow>();
        if (bioPaxObject instanceof Conversion) {
            for (ReactionStep rs : bioModel.getModel().getReactionSteps()) {
                BioPaxRelationshipTableRow entityRow = new BioPaxRelationshipTableRow(rs);
                if (relationshipObjects != null) {
                    for (RelationshipObject ro : relationshipObjects) {
                        if (ro.getBioModelEntityObject() == rs) {
                            entityRow.setSelected(true);
                            break;
                        }
                    }
                }
                if (!bShowLinkOnly || entityRow.selected) {
                    allEntityRows.add(entityRow);
                }
            }
            for (ReactionRule rr : bioModel.getModel().getRbmModelContainer().getReactionRuleList()) {
                BioPaxRelationshipTableRow entityRow = new BioPaxRelationshipTableRow(rr);
                if (relationshipObjects != null) {
                    for (RelationshipObject ro : relationshipObjects) {
                        if (ro.getBioModelEntityObject() == rr) {
                            entityRow.setSelected(true);
                            break;
                        }
                    }
                }
                if (!bShowLinkOnly || entityRow.selected) {
                    allEntityRows.add(entityRow);
                }
            }
        } else if (bioPaxObject instanceof PhysicalEntity) {
            for (SpeciesContext rs : bioModel.getModel().getSpeciesContexts()) {
                BioPaxRelationshipTableRow entityRow = new BioPaxRelationshipTableRow(rs);
                if (relationshipObjects != null) {
                    for (RelationshipObject ro : relationshipObjects) {
                        if (ro.getBioModelEntityObject() == rs) {
                            entityRow.setSelected(true);
                            break;
                        }
                    }
                }
                if (!bShowLinkOnly || entityRow.selected) {
                    allEntityRows.add(entityRow);
                }
            }
        }
        if (searchText == null || searchText.length() == 0) {
            entityRows.addAll(allEntityRows);
        } else {
            for (BioPaxRelationshipTableRow rs : allEntityRows) {
                BioModelEntityObject object = rs.getBioModelEntityObject();
                String lowerCaseSearchText = searchText.toLowerCase();
                if (object.getName().toLowerCase().contains(lowerCaseSearchText) || object.getTypeLabel().toLowerCase().contains(lowerCaseSearchText)) {
                    entityRows.add(rs);
                }
            }
        }
    }
    setData(entityRows);
    GuiUtils.flexResizeTableColumns(ownerTable);
}

Example 4 with Conversion

use of org.vcell.pathway.Conversion in project vcell by virtualcell.

the class PathwayGraphModel method refreshControl.

private void refreshControl(Control control) {
    Interaction controlledInteraction = control.getControlledInteraction();
    if (controlledInteraction instanceof Conversion) {
        List<InteractionParticipant> physicalControllers = control.getParticipants();
        if (physicalControllers != null) {
            Conversion conversion = (Conversion) controlledInteraction;
            BioPaxObject ancestorObject = pathwayModel.findTopLevelGroupAncestor(conversion);
            if (ancestorObject == conversion) {
                // conversion was not grouped
                BioPaxConversionShape conversionShape = (BioPaxConversionShape) getShapeFromModelObject(conversion);
                if (conversionShape != null) {
                    for (InteractionParticipant participant : physicalControllers) {
                        refreshParticipant(conversionShape, participant);
                    }
                }
            } else {
                if (ancestorObject instanceof GroupObject) {
                    // conversion has been grouped
                    GroupObject groupObject = (GroupObject) ancestorObject;
                    for (InteractionParticipant participant : physicalControllers) {
                        refreshGroupInteraction(groupObject, participant);
                    }
                }
            }
        }
    }
}

Example 5 with Conversion

use of org.vcell.pathway.Conversion in project vcell by virtualcell.

the class PathwayGraphModel method refreshAll.

@Override
public void refreshAll() {
    if (pathwayModel == null) {
        clearAllShapes();
        fireGraphChanged();
        return;
    }
    unwantedShapes = new HashSet<Shape>();
    unwantedShapes.addAll(getShapes());
    pathwayContainerShape = (PathwayContainerShape) getShapeFromModelObject(pathwayModel);
    if (pathwayContainerShape == null) {
        pathwayContainerShape = new PathwayContainerShape(this, pathwayModel);
        pathwayContainerShape.getSpaceManager().setSize(400, 300);
        addShape(pathwayContainerShape);
    }
    unwantedShapes.remove(pathwayContainerShape);
    Set<BioPaxObject> bioPaxObjects = new HashSet<BioPaxObject>(pathwayModel.getDisplayableBioPaxObjectList());
    for (BioPaxObject bpObject : bioPaxObjects) {
        BioPaxShape bpObjectShape = (BioPaxShape) getShapeFromModelObject(bpObject);
        if (bpObjectShape == null) {
            if (bpObject instanceof Conversion) {
                bpObjectShape = new BioPaxConversionShape((Conversion) bpObject, this);
            } else if (bpObject instanceof MolecularInteraction) {
                bpObjectShape = new BioPaxMolecularInteractionShape((MolecularInteraction) bpObject, this);
            } else if (bpObject instanceof Protein) {
                bpObjectShape = new BioPaxProteinShape((Protein) bpObject, this);
            } else if (bpObject instanceof Complex) {
                bpObjectShape = new BioPaxComplexShape((Complex) bpObject, this);
            } else if (bpObject instanceof SmallMolecule) {
                bpObjectShape = new BioPaxSmallMoleculeShape((SmallMolecule) bpObject, this);
            } else if (bpObject instanceof Dna) {
                bpObjectShape = new BioPaxDnaShape((Dna) bpObject, this);
            } else if (bpObject instanceof Rna) {
                bpObjectShape = new BioPaxRnaShape((Rna) bpObject, this);
            } else if (bpObject instanceof PhysicalEntity) {
                bpObjectShape = new BioPaxPhysicalEntityShape((PhysicalEntity) bpObject, this);
            } else if (bpObject instanceof GroupObject) {
                bpObjectShape = new BioPaxGroupShape((GroupObject) bpObject, this);
            } else {
                bpObjectShape = new BioPaxObjectShape(bpObject, this);
            }
            if (!(bpObject instanceof Control)) {
                // the Control objects will not be displayed on the diagram
                pathwayContainerShape.addChildShape(bpObjectShape);
                addShape(bpObjectShape);
            }
            Dimension shapeSize = bpObjectShape.getSpaceManager().getSize();
            Rectangle boundary = getContainerLayout().getBoundaryForAutomaticLayout(pathwayContainerShape);
            int xPos = boundary.x + random.nextInt(boundary.width - shapeSize.width);
            int yPos = boundary.y + random.nextInt(boundary.height - shapeSize.height);
            bpObjectShape.setAbsPos(xPos, yPos);
        }
        unwantedShapes.remove(bpObjectShape);
    }
    for (BioPaxObject bpObject : bioPaxObjects) {
        if (bpObject instanceof Conversion) {
            refreshInteraction((Conversion) bpObject);
        } else if (bpObject instanceof MolecularInteraction) {
            refreshInteraction((MolecularInteraction) bpObject);
        } else if (bpObject instanceof Control) {
            refreshControl((Control) bpObject);
        } else if (bpObject instanceof GroupObject) {
            refreshGroupObject((GroupObject) bpObject);
        }
    }
    for (Shape unwantedShape : unwantedShapes) {
        removeShape(unwantedShape);
    }
    refreshRelationshipInfo();
    fireGraphChanged();
}