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Example 1 with MembraneRegionVariable

use of cbit.vcell.math.MembraneRegionVariable in project vcell by virtualcell.

the class TestingFrameworkWindowManager method getVariableNamesToCompare.

// /**
// * Insert the method's description here.
// * Creation date: (11/23/2004 1:53:11 PM)
// * @return java.lang.String[]
// * @param sim1 cbit.vcell.solver.Simulation
// * @param sim2 cbit.vcell.solver.Simulation
// */
// private VariablePair[] getVariableNamesToCompare(BioModel testBioModel,SimulationSymbolTable testSymboltable, SimulationSymbolTable refSymbolTable){
// Vector<VariablePair> variablePairs = new Vector<VariablePair>();
// 
// //
// // get Variables from Simulation 1
// //
// Variable refVars[] = refSymbolTable.getVariables();
// for (int i = 0;refVars!=null && i < refVars.length; i++){
// if (refVars[i] instanceof VolVariable ||
// refVars[i] instanceof StochVolVariable ||
// refVars[i] instanceof MemVariable ||
// refVars[i] instanceof VolumeRegionVariable ||
// refVars[i] instanceof MembraneRegionVariable ||
// refVars[i] instanceof FilamentVariable ||
// refVars[i] instanceof FilamentRegionVariable){
// 
// VariablePair varPair = new VariablePair();
// varPair.refVariable = refVars[i];
// varPair.domain = refVars[i].getDomain();
// varPair.testVariable = null;
// variablePairs.add(varPair);
// }
// //		Constant sensitivityParameter = simSymbolTable1.getSimulation().getSolverTaskDescription().getSensitivityParameter();
// //		if (sensitivityParameter != null) {
// //			if (simVars[i] instanceof VolVariable) {
// //				hashSet.add(SensVariable.getSensName((VolVariable)simVars[i], sensitivityParameter));
// //			}
// //		}
// }
// 
// //
// // add Variables from Simulation 2
// //
// Variable[] testVars = testSymboltable.getVariables();
// for (int i = 0;testVars!=null && i < testVars.length; i++){
// if (testVars[i] instanceof VolVariable ||
// testVars[i] instanceof MemVariable ||
// testVars[i] instanceof VolumeRegionVariable ||
// testVars[i] instanceof MembraneRegionVariable ||
// testVars[i] instanceof FilamentVariable ||
// testVars[i] instanceof FilamentRegionVariable){
// 
// if(testVars[i].getDomain() == null){
// boolean BFoundMatchingName = false;
// for (int j = 0; j < variablePairs.size(); j++) {
// VariablePair varPair = variablePairs.elementAt(j);
// if(varPair.refVariable.getName().equals(testVars[i].getName())){
// varPair.testVariable = testVars[i];
// BFoundMatchingName = true;
// break;
// }
// }
// if(!BFoundMatchingName){
// //Try to find other matching variable types (e.g. functions)
// Variable dataSet1Match = refSymbolTable.getVariable(testVars[i].getName());
// if(dataSet1Match != null){
// VariablePair varPair = new VariablePair();
// varPair.refVariable = dataSet1Match;
// varPair.testVariable = testVars[i];
// varPair.domain = varPair.refVariable.getDomain();
// variablePairs.add(varPair);
// }else{
// SpeciesContext testSpeciescontext0 = testBioModel.getModel().getSpeciesContext(testVars[i].getName());
// if(testSpeciescontext0 != null){
// Species refspecies = testSpeciescontext0.getSpecies();
// Variable refVariable = refSymbolTable.getVariable(refspecies.getCommonName());
// if(refVariable != null){
// VariablePair varPair = new VariablePair();
// varPair.refVariable = refVariable;
// varPair.testVariable = testVars[i];
// varPair.domain = varPair.refVariable.getDomain();
// variablePairs.add(varPair);
// }
// }else{
// Species testSpecies = testBioModel.getModel().getSpecies(testVars[i].getName());
// if(testSpecies != null){
// for (int j = 0; j < testBioModel.getModel().getSpeciesContexts().length; j++) {
// if(testBioModel.getModel().getSpeciesContexts()[j].getSpecies() == testSpecies){
// Variable refVar = refSymbolTable.getVariable(testBioModel.getModel().getSpeciesContexts()[j].getName());
// if(refVar != null){
// VariablePair varPair = new VariablePair();
// varPair.refVariable = refVar;
// varPair.testVariable = testVars[i];
// varPair.domain = varPair.refVariable.getDomain();
// variablePairs.add(varPair);
// }
// }
// }
// }
// }
// }
// }
// }else{
// 
// }
// hashSet.add(simVars[i].getName());
// }
// Constant sensitivityParameter = refSymbolTable.getSimulation().getSolverTaskDescription().getSensitivityParameter();
// if (sensitivityParameter != null) {
// if (simVars[i] instanceof VolVariable) {
// hashSet.add(SensVariable.getSensName((VolVariable)simVars[i], sensitivityParameter));
// }
// }
// }
// 
// return (String[])hashSet.toArray(new String[hashSet.size()]);
// }
/**
 * Insert the method's description here.
 * Creation date: (11/23/2004 1:53:11 PM)
 * @return java.lang.String[]
 * @param sim1 cbit.vcell.solver.Simulation
 * @param sim2 cbit.vcell.solver.Simulation
 */
private String[] getVariableNamesToCompare(SimulationSymbolTable simSymbolTable1, SimulationSymbolTable simSymbolTable2) {
    java.util.HashSet<String> hashSet = new java.util.HashSet<String>();
    // 
    // get Variables from Simulation 1
    // 
    Variable[] simVars = simSymbolTable1.getVariables();
    for (int i = 0; simVars != null && i < simVars.length; i++) {
        if (simVars[i] instanceof VolVariable || simVars[i] instanceof StochVolVariable || simVars[i] instanceof MemVariable || simVars[i] instanceof VolumeRegionVariable || simVars[i] instanceof MembraneRegionVariable || simVars[i] instanceof FilamentVariable || simVars[i] instanceof FilamentRegionVariable) {
            hashSet.add(simVars[i].getName());
        }
        Constant sensitivityParameter = simSymbolTable1.getSimulation().getSolverTaskDescription().getSensitivityParameter();
        if (sensitivityParameter != null) {
            if (simVars[i] instanceof VolVariable) {
                hashSet.add(SensVariable.getSensName((VolVariable) simVars[i], sensitivityParameter));
            }
        }
    }
    // 
    // add Variables from Simulation 2
    // 
    simVars = simSymbolTable2.getVariables();
    for (int i = 0; simVars != null && i < simVars.length; i++) {
        if (simVars[i] instanceof VolVariable || simVars[i] instanceof MemVariable || simVars[i] instanceof VolumeRegionVariable || simVars[i] instanceof MembraneRegionVariable || simVars[i] instanceof FilamentVariable || simVars[i] instanceof FilamentRegionVariable) {
            hashSet.add(simVars[i].getName());
        }
        Constant sensitivityParameter = simSymbolTable2.getSimulation().getSolverTaskDescription().getSensitivityParameter();
        if (sensitivityParameter != null) {
            if (simVars[i] instanceof VolVariable) {
                hashSet.add(SensVariable.getSensName((VolVariable) simVars[i], sensitivityParameter));
            }
        }
    }
    return (String[]) hashSet.toArray(new String[hashSet.size()]);
}
Also used : SensVariable(cbit.vcell.solver.ode.SensVariable) FilamentVariable(cbit.vcell.math.FilamentVariable) VolVariable(cbit.vcell.math.VolVariable) StochVolVariable(cbit.vcell.math.StochVolVariable) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) VolumeRegionVariable(cbit.vcell.math.VolumeRegionVariable) MemVariable(cbit.vcell.math.MemVariable) FilamentRegionVariable(cbit.vcell.math.FilamentRegionVariable) Variable(cbit.vcell.math.Variable) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) VolVariable(cbit.vcell.math.VolVariable) StochVolVariable(cbit.vcell.math.StochVolVariable) FilamentRegionVariable(cbit.vcell.math.FilamentRegionVariable) Constant(cbit.vcell.math.Constant) VolumeRegionVariable(cbit.vcell.math.VolumeRegionVariable) MemVariable(cbit.vcell.math.MemVariable) FilamentVariable(cbit.vcell.math.FilamentVariable) StochVolVariable(cbit.vcell.math.StochVolVariable) HashSet(java.util.HashSet)

Example 2 with MembraneRegionVariable

use of cbit.vcell.math.MembraneRegionVariable in project vcell by virtualcell.

the class DiffEquMathMapping method refreshMathDescription.

/**
 * This method was created in VisualAge.
 */
@SuppressWarnings("deprecation")
private void refreshMathDescription() throws MappingException, MatrixException, MathException, ExpressionException, ModelException {
    // All sizes must be set for new ODE models and ratios must be set for old ones.
    simContext.checkValidity();
    // 
    // temporarily place all variables in a hashtable (before binding) and discarding duplicates (check for equality)
    // 
    VariableHash varHash = new VariableHash();
    StructureMapping[] structureMappings = simContext.getGeometryContext().getStructureMappings();
    // 
    // verify that all structures are mapped to subvolumes and all subvolumes are mapped to a structure
    // 
    // Structure structures[] =
    simContext.getGeometryContext().getModel().getStructures();
    // for (int i = 0; i < structures.length; i++){
    // StructureMapping sm = simContext.getGeometryContext().getStructureMapping(structures[i]);
    // if (sm==null || (sm.getGeometryClass() == null)){
    // localIssueList.add(new Issue(structures[i], IssueCategory.StructureNotMapped,"In Application '" + simContext.getName() + "', model structure '"+structures[i].getName()+"' not mapped to a geometry subdomain",Issue.SEVERITY_WARNING));
    // }
    // }
    // SubVolume subVolumes[] = simContext.getGeometryContext().getGeometry().getGeometrySpec().getSubVolumes();
    // for (int i = 0; i < subVolumes.length; i++){
    // Structure[] mappedStructures = simContext.getGeometryContext().getStructuresFromGeometryClass(subVolumes[i]);
    // if (mappedStructures==null || mappedStructures.length==0){
    // localIssueList.add(new Issue(subVolumes[i], IssueCategory.GeometryClassNotMapped,"In Application '" + simContext.getName() + "', geometry subVolume '"+subVolumes[i].getName()+"' not mapped from a model structure",Issue.SEVERITY_WARNING));
    // }
    // }
    // deals with model parameters
    HashMap<VolVariable, EventAssignmentOrRateRuleInitParameter> eventVolVarHash = new HashMap<VolVariable, EventAssignmentOrRateRuleInitParameter>();
    HashMap<Variable, RateRuleRateParameter> rateRuleRateParamHash = new HashMap<Variable, RateRuleRateParameter>();
    ArrayList<SymbolTableEntry> rateRuleVarTargets = new ArrayList<SymbolTableEntry>();
    ArrayList<SymbolTableEntry> assignmentRuleVarTargets = new ArrayList<SymbolTableEntry>();
    ArrayList<SymbolTableEntry> eventAssignTargets = new ArrayList<SymbolTableEntry>();
    Model model = simContext.getModel();
    ModelUnitSystem modelUnitSystem = model.getUnitSystem();
    VCUnitDefinition timeUnit = modelUnitSystem.getTimeUnit();
    ModelParameter[] modelParameters = model.getModelParameters();
    if (simContext.getGeometry().getDimension() == 0) {
        // 
        // global parameters from model (that presently are constants)
        // 
        BioEvent[] bioEvents = simContext.getBioEvents();
        if (bioEvents != null && bioEvents.length > 0) {
            for (BioEvent be : bioEvents) {
                ArrayList<EventAssignment> eventAssignments = be.getEventAssignments();
                if (eventAssignments != null) {
                    for (EventAssignment ea : eventAssignments) {
                        if (!eventAssignTargets.contains(ea.getTarget())) {
                            eventAssignTargets.add(ea.getTarget());
                        }
                    }
                }
            }
        }
        RateRule[] rrs = simContext.getRateRules();
        if (rrs != null && rrs.length > 0) {
            for (RateRule rr : rrs) {
                SymbolTableEntry rrVar = rr.getRateRuleVar();
                if (!rateRuleVarTargets.contains(rrVar)) {
                    rateRuleVarTargets.add(rrVar);
                }
            }
        }
        AssignmentRule[] ars = simContext.getAssignmentRules();
        if (ars != null && ars.length > 0) {
            for (AssignmentRule ar : ars) {
                SymbolTableEntry arVar = ar.getAssignmentRuleVar();
                if (!assignmentRuleVarTargets.contains(arVar)) {
                    assignmentRuleVarTargets.add(arVar);
                }
            }
        }
        for (int j = 0; j < modelParameters.length; j++) {
            Expression modelParamExpr = modelParameters[j].getExpression();
            GeometryClass geometryClass = getDefaultGeometryClass(modelParamExpr);
            VCUnitDefinition paramUnit = modelParameters[j].getUnitDefinition();
            modelParamExpr = getIdentifierSubstitutions(modelParamExpr, paramUnit, geometryClass);
            // if (eventAssignTargets.contains(modelParameters[j]) || rateRuleVarTargets.contains(modelParameters[j])) {
            if (eventAssignTargets.contains(modelParameters[j])) {
                EventAssignmentOrRateRuleInitParameter eap = null;
                try {
                    eap = addEventAssignmentOrRateRuleInitParameter(modelParameters[j], modelParamExpr, PARAMETER_ROLE_EVENTASSIGN_OR_RATERULE_INITCONDN, paramUnit);
                } catch (PropertyVetoException e) {
                    e.printStackTrace(System.out);
                    throw new MappingException(e.getMessage());
                }
                if (geometryClass == null) {
                    GeometryClass[] geometryClasses = simContext.getGeometryContext().getGeometry().getGeometryClasses();
                    geometryClass = geometryClasses[0];
                }
                Domain domain = null;
                if (geometryClass != null) {
                    // the volume variable will look like Compartment::g0 rather than just g0
                    domain = new Domain(geometryClass);
                }
                VolVariable volVar = new VolVariable(modelParameters[j].getName(), domain);
                varHash.addVariable(volVar);
                eventVolVarHash.put(volVar, eap);
            } else if (rateRuleVarTargets.contains(modelParameters[j])) {
                // do nothing, will do elsewhere
                ;
            } else if (assignmentRuleVarTargets.contains(modelParameters[j])) {
                // do nothing, will do elsewhere
                ;
            } else {
                Variable variable = newFunctionOrConstant(getMathSymbol(modelParameters[j], geometryClass), modelParamExpr, geometryClass);
                varHash.addVariable(variable);
            }
        }
    } else {
        for (int j = 0; j < modelParameters.length; j++) {
            Expression modelParamExpr = modelParameters[j].getExpression();
            GeometryClass geometryClass = getDefaultGeometryClass(modelParamExpr);
            modelParamExpr = getIdentifierSubstitutions(modelParamExpr, modelParameters[j].getUnitDefinition(), geometryClass);
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(modelParameters[j], geometryClass), modelParamExpr, geometryClass));
        }
    }
    // 
    for (SimulationContextParameter scParameter : simContext.getSimulationContextParameters()) {
        Expression scParameterExpression = scParameter.getExpression();
        GeometryClass gc = getDefaultGeometryClass(scParameterExpression);
        varHash.addVariable(newFunctionOrConstant(getMathSymbol(scParameter, gc), getIdentifierSubstitutions(scParameter.getExpression(), scParameter.getUnitDefinition(), gc), gc));
    }
    // 
    for (DataSymbol dataSymbol : simContext.getDataContext().getDataSymbols()) {
        if (dataSymbol instanceof FieldDataSymbol) {
            FieldDataSymbol fieldDataSymbol = (FieldDataSymbol) dataSymbol;
            GeometryClass geometryClass = null;
            FieldFunctionArguments ffs = new FieldFunctionArguments(fieldDataSymbol.getExternalDataIdentifier().getName(), fieldDataSymbol.getFieldDataVarName(), new Expression(fieldDataSymbol.getFieldDataVarTime()), VariableType.getVariableTypeFromVariableTypeName(fieldDataSymbol.getFieldDataVarType()));
            Expression exp = new Expression(ffs.infix());
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(dataSymbol, geometryClass), getIdentifierSubstitutions(exp, dataSymbol.getUnitDefinition(), geometryClass), geometryClass));
        } else {
            throw new RuntimeException("In Application '" + simContext.getName() + "', dataSymbol type '" + dataSymbol.getClass().getName() + "' not yet supported for math generation");
        }
    }
    // 
    // gather only those reactionSteps that are not "excluded"
    // 
    ReactionSpec[] reactionSpecs = simContext.getReactionContext().getReactionSpecs();
    Vector<ReactionStep> rsList = new Vector<ReactionStep>();
    for (int i = 0; i < reactionSpecs.length; i++) {
        if (reactionSpecs[i].isExcluded() == false) {
            rsList.add(reactionSpecs[i].getReactionStep());
        }
    }
    ReactionStep[] reactionSteps = new ReactionStep[rsList.size()];
    rsList.copyInto(reactionSteps);
    // 
    for (int i = 0; i < reactionSteps.length; i++) {
        Kinetics.UnresolvedParameter[] unresolvedParameters = reactionSteps[i].getKinetics().getUnresolvedParameters();
        if (unresolvedParameters != null && unresolvedParameters.length > 0) {
            StringBuffer buffer = new StringBuffer();
            for (int j = 0; j < unresolvedParameters.length; j++) {
                if (j > 0) {
                    buffer.append(", ");
                }
                buffer.append(unresolvedParameters[j].getName());
            }
            throw new MappingException("In Application '" + simContext.getName() + "', " + reactionSteps[i].getDisplayType() + " '" + reactionSteps[i].getName() + "' contains unresolved identifier(s): " + buffer);
        }
    }
    // 
    // create new MathDescription (based on simContext's previous MathDescription if possible)
    // 
    MathDescription oldMathDesc = simContext.getMathDescription();
    mathDesc = null;
    if (oldMathDesc != null) {
        if (oldMathDesc.getVersion() != null) {
            mathDesc = new MathDescription(oldMathDesc.getVersion());
        } else {
            mathDesc = new MathDescription(oldMathDesc.getName());
        }
    } else {
        mathDesc = new MathDescription(simContext.getName() + "_generated");
    }
    // 
    // volume variables
    // 
    Enumeration<SpeciesContextMapping> enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = enum1.nextElement();
        if (scm.getVariable() instanceof VolVariable) {
            if (!(mathDesc.getVariable(scm.getVariable().getName()) instanceof VolVariable)) {
                varHash.addVariable(scm.getVariable());
            }
        }
    }
    // 
    // membrane variables
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof MemVariable) {
            varHash.addVariable(scm.getVariable());
        }
    }
    // 
    // volume region variables
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof VolumeRegionVariable) {
            varHash.addVariable(scm.getVariable());
        }
    }
    // 
    // membrane region variables
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof MembraneRegionVariable) {
            varHash.addVariable(scm.getVariable());
        }
    }
    // 
    // add compartment and membrane subdomains
    // 
    ArrayList<CompartmentSubdomainContext> compartmentSubdomainContexts = new ArrayList<CompartmentSubdomainContext>();
    ArrayList<MembraneSubdomainContext> membraneSubdomainContexts = new ArrayList<MembraneSubdomainContext>();
    addSubdomains(model, compartmentSubdomainContexts, membraneSubdomainContexts);
    // membrane velocities set on MembraneSubdomains later.
    addSpatialProcesses(varHash, compartmentSubdomainContexts, membraneSubdomainContexts);
    varHash.addVariable(new Constant(getMathSymbol(model.getPI_CONSTANT(), null), getIdentifierSubstitutions(model.getPI_CONSTANT().getExpression(), model.getPI_CONSTANT().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getFARADAY_CONSTANT(), null), getIdentifierSubstitutions(model.getFARADAY_CONSTANT().getExpression(), model.getFARADAY_CONSTANT().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getFARADAY_CONSTANT_NMOLE(), null), getIdentifierSubstitutions(model.getFARADAY_CONSTANT_NMOLE().getExpression(), model.getFARADAY_CONSTANT_NMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getGAS_CONSTANT(), null), getIdentifierSubstitutions(model.getGAS_CONSTANT().getExpression(), model.getGAS_CONSTANT().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getTEMPERATURE(), null), getIdentifierSubstitutions(new Expression(simContext.getTemperatureKelvin()), model.getTEMPERATURE().getUnitDefinition(), null)));
    // 
    // only calculate potential if at least one MembraneMapping has CalculateVoltage == true
    // 
    boolean bCalculatePotential = false;
    for (int i = 0; i < structureMappings.length; i++) {
        if (structureMappings[i] instanceof MembraneMapping) {
            if (((MembraneMapping) structureMappings[i]).getCalculateVoltage()) {
                bCalculatePotential = true;
            }
        }
    }
    potentialMapping = new PotentialMapping(simContext, this);
    if (bCalculatePotential) {
        potentialMapping.computeMath();
        // 
        // copy functions for currents and constants for capacitances
        // 
        ElectricalDevice[] devices = potentialMapping.getElectricalDevices();
        for (int j = 0; j < devices.length; j++) {
            if (devices[j] instanceof MembraneElectricalDevice) {
                MembraneElectricalDevice membraneElectricalDevice = (MembraneElectricalDevice) devices[j];
                MembraneMapping memMapping = membraneElectricalDevice.getMembraneMapping();
                Parameter specificCapacitanceParm = memMapping.getParameterFromRole(MembraneMapping.ROLE_SpecificCapacitance);
                varHash.addVariable(new Constant(getMathSymbol(specificCapacitanceParm, memMapping.getGeometryClass()), getIdentifierSubstitutions(specificCapacitanceParm.getExpression(), specificCapacitanceParm.getUnitDefinition(), memMapping.getGeometryClass())));
                ElectricalDevice.ElectricalDeviceParameter transmembraneCurrentParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_TransmembraneCurrent);
                ElectricalDevice.ElectricalDeviceParameter totalCurrentParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_TotalCurrent);
                ElectricalDevice.ElectricalDeviceParameter capacitanceParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_Capacitance);
                GeometryClass geometryClass = membraneElectricalDevice.getMembraneMapping().getGeometryClass();
                if (totalCurrentParm != null && /* totalCurrentDensityParm.getExpression()!=null && */
                memMapping.getCalculateVoltage()) {
                    Expression totalCurrentDensityExp = (totalCurrentParm.getExpression() != null) ? (totalCurrentParm.getExpression()) : (new Expression(0.0));
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, geometryClass), getIdentifierSubstitutions(totalCurrentDensityExp, totalCurrentParm.getUnitDefinition(), geometryClass), geometryClass));
                }
                if (transmembraneCurrentParm != null && transmembraneCurrentParm.getExpression() != null && memMapping.getCalculateVoltage()) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(transmembraneCurrentParm, geometryClass), getIdentifierSubstitutions(transmembraneCurrentParm.getExpression(), transmembraneCurrentParm.getUnitDefinition(), geometryClass), geometryClass));
                }
                if (capacitanceParm != null && capacitanceParm.getExpression() != null && memMapping.getCalculateVoltage()) {
                    StructureMappingParameter sizeParameter = membraneElectricalDevice.getMembraneMapping().getSizeParameter();
                    if (simContext.getGeometry().getDimension() == 0 && (sizeParameter.getExpression() == null || sizeParameter.getExpression().isZero())) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(capacitanceParm, geometryClass), getIdentifierSubstitutions(Expression.mult(memMapping.getNullSizeParameterValue(), specificCapacitanceParm.getExpression()), capacitanceParm.getUnitDefinition(), geometryClass), geometryClass));
                    } else {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(capacitanceParm, geometryClass), getIdentifierSubstitutions(capacitanceParm.getExpression(), capacitanceParm.getUnitDefinition(), geometryClass), geometryClass));
                    }
                }
                // 
                if (membraneElectricalDevice.getDependentVoltageExpression() == null) {
                    // is Voltage Independent?
                    StructureMapping.StructureMappingParameter initialVoltageParm = memMapping.getInitialVoltageParameter();
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(initialVoltageParm, memMapping.getGeometryClass()), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), memMapping.getGeometryClass()), memMapping.getGeometryClass()));
                } else // 
                // membrane forced potential
                // 
                {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(memMapping.getMembrane().getMembraneVoltage(), memMapping.getGeometryClass()), getIdentifierSubstitutions(membraneElectricalDevice.getDependentVoltageExpression(), memMapping.getMembrane().getMembraneVoltage().getUnitDefinition(), memMapping.getGeometryClass()), memMapping.getGeometryClass()));
                }
            } else if (devices[j] instanceof CurrentClampElectricalDevice) {
                CurrentClampElectricalDevice currentClampDevice = (CurrentClampElectricalDevice) devices[j];
                // total current = current source (no capacitance)
                Parameter totalCurrentParm = currentClampDevice.getParameterFromRole(CurrentClampElectricalDevice.ROLE_TotalCurrent);
                Parameter currentParm = currentClampDevice.getParameterFromRole(CurrentClampElectricalDevice.ROLE_TransmembraneCurrent);
                // Parameter dependentVoltage = currentClampDevice.getCurrentClampStimulus().getVoltageParameter();
                Feature deviceElectrodeFeature = currentClampDevice.getCurrentClampStimulus().getElectrode().getFeature();
                Feature groundElectrodeFeature = simContext.getGroundElectrode().getFeature();
                Membrane membrane = model.getStructureTopology().getMembrane(deviceElectrodeFeature, groundElectrodeFeature);
                GeometryClass geometryClass = null;
                if (membrane != null) {
                    StructureMapping membraneStructureMapping = simContext.getGeometryContext().getStructureMapping(membrane);
                    geometryClass = membraneStructureMapping.getGeometryClass();
                }
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, geometryClass), getIdentifierSubstitutions(totalCurrentParm.getExpression(), totalCurrentParm.getUnitDefinition(), geometryClass), geometryClass));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(currentParm, geometryClass), getIdentifierSubstitutions(currentParm.getExpression(), currentParm.getUnitDefinition(), geometryClass), geometryClass));
                // varHash.addVariable(newFunctionOrConstant(getMathSymbol(dependentVoltage,null),getIdentifierSubstitutions(currentClampDevice.getDependentVoltageExpression(),dependentVoltage.getUnitDefinition(),null)));
                // 
                // add user-defined parameters
                // 
                ElectricalDevice.ElectricalDeviceParameter[] parameters = currentClampDevice.getParameters();
                for (int k = 0; k < parameters.length; k++) {
                    if (parameters[k].getExpression() != null) {
                        // guards against voltage parameters that are "variable".
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(parameters[k], null), getIdentifierSubstitutions(parameters[k].getExpression(), parameters[k].getUnitDefinition(), geometryClass), geometryClass));
                    }
                }
            } else if (devices[j] instanceof VoltageClampElectricalDevice) {
                VoltageClampElectricalDevice voltageClampDevice = (VoltageClampElectricalDevice) devices[j];
                Feature deviceElectrodeFeature = voltageClampDevice.getVoltageClampStimulus().getElectrode().getFeature();
                Feature groundElectrodeFeature = simContext.getGroundElectrode().getFeature();
                Membrane membrane = model.getStructureTopology().getMembrane(deviceElectrodeFeature, groundElectrodeFeature);
                GeometryClass geometryClass = null;
                if (membrane != null) {
                    StructureMapping membraneStructureMapping = simContext.getGeometryContext().getStructureMapping(membrane);
                    geometryClass = membraneStructureMapping.getGeometryClass();
                }
                // total current = current source (no capacitance)
                Parameter totalCurrent = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_TotalCurrent);
                Parameter totalCurrentParm = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_TotalCurrent);
                Parameter voltageParm = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_Voltage);
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrent, geometryClass), getIdentifierSubstitutions(totalCurrent.getExpression(), totalCurrent.getUnitDefinition(), geometryClass), geometryClass));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, geometryClass), getIdentifierSubstitutions(totalCurrentParm.getExpression(), totalCurrentParm.getUnitDefinition(), geometryClass), geometryClass));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(voltageParm, geometryClass), getIdentifierSubstitutions(voltageParm.getExpression(), voltageParm.getUnitDefinition(), geometryClass), geometryClass));
                // 
                // add user-defined parameters
                // 
                ElectricalDevice.ElectricalDeviceParameter[] parameters = voltageClampDevice.getParameters();
                for (int k = 0; k < parameters.length; k++) {
                    if (parameters[k].getRole() == ElectricalDevice.ROLE_UserDefined) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(parameters[k], geometryClass), getIdentifierSubstitutions(parameters[k].getExpression(), parameters[k].getUnitDefinition(), geometryClass), geometryClass));
                    }
                }
            }
        }
    } else {
        // 
        for (int j = 0; j < structureMappings.length; j++) {
            if (structureMappings[j] instanceof MembraneMapping) {
                MembraneMapping memMapping = (MembraneMapping) structureMappings[j];
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(memMapping.getMembrane().getMembraneVoltage(), memMapping.getGeometryClass()), getIdentifierSubstitutions(memMapping.getInitialVoltageParameter().getExpression(), memMapping.getInitialVoltageParameter().getUnitDefinition(), memMapping.getGeometryClass()), memMapping.getGeometryClass()));
            }
        }
    }
    // 
    for (int j = 0; j < structureMappings.length; j++) {
        if (structureMappings[j] instanceof MembraneMapping) {
            MembraneMapping membraneMapping = (MembraneMapping) structureMappings[j];
            Membrane.MembraneVoltage membraneVoltage = membraneMapping.getMembrane().getMembraneVoltage();
            ElectricalDevice[] membraneDevices = potentialMapping.getElectricalDevices(membraneMapping.getMembrane());
            // ElectricalDevice membraneDevice = null;
            for (int i = 0; i < membraneDevices.length; i++) {
                if (membraneDevices[i].hasCapacitance() && membraneDevices[i].getDependentVoltageExpression() == null) {
                    GeometryClass geometryClass = membraneMapping.getGeometryClass();
                    if (geometryClass == null) {
                        throw new MappingException("Application '" + getSimulationContext().getName() + "'\nGeometry->StructureMapping->(" + structureMappings[j].getStructure().getTypeName() + ")'" + structureMappings[j].getStructure().getName() + "' must be mapped to geometry domain.\n(see 'Problems' tab)");
                    }
                    Domain domain = new Domain(geometryClass);
                    if (membraneMapping.getCalculateVoltage() && bCalculatePotential) {
                        if (geometryClass instanceof SurfaceClass) {
                            // 
                            if (mathDesc.getVariable(Membrane.MEMBRANE_VOLTAGE_REGION_NAME) == null) {
                                // varHash.addVariable(new MembraneRegionVariable(MembraneVoltage.MEMBRANE_VOLTAGE_REGION_NAME));
                                varHash.addVariable(new MembraneRegionVariable(getMathSymbol(membraneVoltage, geometryClass), domain));
                            }
                        } else {
                            // 
                            // spatially unresolved membrane, and must solve for potential ... make VolVariable for this compartment
                            // 
                            varHash.addVariable(new VolVariable(getMathSymbol(membraneVoltage, geometryClass), domain));
                        }
                        Parameter initialVoltageParm = membraneMapping.getInitialVoltageParameter();
                        Variable initVoltageFunction = newFunctionOrConstant(getMathSymbol(initialVoltageParm, geometryClass), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), geometryClass), geometryClass);
                        varHash.addVariable(initVoltageFunction);
                    } else {
                        // 
                        // don't calculate voltage, still may need it though
                        // 
                        Parameter initialVoltageParm = membraneMapping.getInitialVoltageParameter();
                        Variable voltageFunction = newFunctionOrConstant(getMathSymbol(membraneMapping.getMembrane().getMembraneVoltage(), geometryClass), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), geometryClass), geometryClass);
                        varHash.addVariable(voltageFunction);
                    }
                }
            }
        }
    }
    // 
    for (int j = 0; j < reactionSteps.length; j++) {
        ReactionStep rs = reactionSteps[j];
        if (simContext.getReactionContext().getReactionSpec(rs).isExcluded()) {
            continue;
        }
        Kinetics.KineticsParameter[] parameters = rs.getKinetics().getKineticsParameters();
        GeometryClass geometryClass = null;
        if (rs.getStructure() != null) {
            geometryClass = simContext.getGeometryContext().getStructureMapping(rs.getStructure()).getGeometryClass();
        }
        if (parameters != null) {
            for (int i = 0; i < parameters.length; i++) {
                if (((parameters[i].getRole() == Kinetics.ROLE_CurrentDensity) || (parameters[i].getRole() == Kinetics.ROLE_LumpedCurrent)) && (parameters[i].getExpression() == null || parameters[i].getExpression().isZero())) {
                    continue;
                }
                String mathSymbol = getMathSymbol(parameters[i], geometryClass);
                Expression expr = getIdentifierSubstitutions(parameters[i].getExpression(), parameters[i].getUnitDefinition(), geometryClass);
                varHash.addVariable(newFunctionOrConstant(mathSymbol, expr, geometryClass));
            }
        }
    }
    // 
    // initial conditions (either function or constant) for rate rule variables that are model parameters
    // 
    // the init variables with expressions still containing variables
    Map<ModelParameter, Variable> initModelParameterHashTmp = new HashMap<>();
    // here we store the init parameter of the model parameter
    Map<EventAssignmentOrRateRuleInitParameter, ModelParameter> rateRuleInitToModelParamMapping = new HashMap<>();
    // here we store the init parameter of the model parameter
    Map<ModelParameter, EventAssignmentOrRateRuleInitParameter> modelParamTorateRuleInitMapping = new HashMap<>();
    for (ModelParameter mp : modelParameters) {
        // initial assignment for global parameter used as rate rule variable
        RateRule rr = simContext.getRateRule(mp);
        if (rr == null) {
            // we only care about global parameters that are rate rule variables
            continue;
        }
        Variable var = varHash.getVariable(mp.getName());
        if (var != null) {
            if (eventVolVarHash.containsKey(var)) {
                System.out.println("Global Parameters that are rate rule Variables should be unmapped at this point, unless they are EventAssignments too.");
            } else {
                throw new MappingException("Global Parameters that are rate rule Variables should be unmapped at this point.");
            }
        }
        Expression modelParamExpr = mp.getExpression();
        if (modelParamExpr == null) {
            continue;
        }
        GeometryClass gc = getDefaultGeometryClass(modelParamExpr);
        VCUnitDefinition paramUnit = modelUnitSystem.getInstance_TBD();
        if (mp.getUnitDefinition() != null && !mp.getUnitDefinition().equals(modelUnitSystem.getInstance_TBD())) {
            paramUnit = mp.getUnitDefinition();
        }
        // TODO: is this really needed? or could I directly use modelParamExpr in addEventAssignmentOrRateRuleInitParameter()
        Expression mpInitExpr = getIdentifierSubstitutions(modelParamExpr, paramUnit, gc);
        EventAssignmentOrRateRuleInitParameter mpInitParam;
        try {
            mpInitParam = addEventAssignmentOrRateRuleInitParameter(mp, mpInitExpr, PARAMETER_ROLE_EVENTASSIGN_OR_RATERULE_INITCONDN, paramUnit);
        } catch (PropertyVetoException e) {
            e.printStackTrace(System.out);
            throw new MappingException(e.getMessage());
        }
        rateRuleInitToModelParamMapping.put(mpInitParam, mp);
        modelParamTorateRuleInitMapping.put(mp, mpInitParam);
    }
    // 
    for (int i = 0; i < fieldMathMappingParameters.length; i++) {
        GeometryClass geometryClass = fieldMathMappingParameters[i].getGeometryClass();
        fieldMathMappingParameters[i].getExpression().bindExpression(this);
        Expression exp = getIdentifierSubstitutions(fieldMathMappingParameters[i].getExpression(), fieldMathMappingParameters[i].getUnitDefinition(), geometryClass);
        Variable var = newFunctionOrConstant(getMathSymbol(fieldMathMappingParameters[i], geometryClass), exp, geometryClass);
        varHash.addVariable(var);
        ModelParameter mp = rateRuleInitToModelParamMapping.get(fieldMathMappingParameters[i]);
        if (mp != null) {
            initModelParameterHashTmp.put(mp, var);
        }
    }
    // 
    // initial conditions (either function or constant) for species variables
    // 
    SpeciesContextSpec[] speciesContextSpecs = simContext.getReactionContext().getSpeciesContextSpecs();
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        // add initial count if present (!= null)
        SpeciesContextSpecParameter initCountParm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_InitialCount);
        SpeciesContext speciesContext = speciesContextSpecs[i].getSpeciesContext();
        if (initCountParm != null && initCountParm.getExpression() != null) {
            Expression initCountExpr = new Expression(initCountParm.getExpression());
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContext.getStructure());
            String[] symbols = initCountExpr.getSymbols();
            // Check if 'initExpr' has other speciesContexts in its expression, need to replace it with 'spContext_init'
            for (int j = 0; symbols != null && j < symbols.length; j++) {
                // if symbol is a speciesContext, replacing it with a reference to initial condition for that speciesContext.
                SpeciesContext spC = null;
                SymbolTableEntry ste = initCountExpr.getSymbolBinding(symbols[j]);
                if (ste instanceof SpeciesContextSpecProxyParameter) {
                    SpeciesContextSpecProxyParameter spspp = (SpeciesContextSpecProxyParameter) ste;
                    if (spspp.getTarget() instanceof SpeciesContext) {
                        spC = (SpeciesContext) spspp.getTarget();
                        SpeciesContextSpec spcspec = simContext.getReactionContext().getSpeciesContextSpec(spC);
                        SpeciesContextSpecParameter spCInitParm = spcspec.getParameterFromRole(SpeciesContextSpec.ROLE_InitialCount);
                        // need to get init condn expression, but can't get it from getMathSymbol() (mapping between bio and math), hence get it as below.
                        Expression scsInitExpr = new Expression(spCInitParm, getNameScope());
                        initCountExpr.substituteInPlace(new Expression(spC.getName()), scsInitExpr);
                    }
                }
            }
            // now create the appropriate function for the current speciesContextSpec.
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(initCountParm, sm.getGeometryClass()), getIdentifierSubstitutions(initCountExpr, initCountParm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        // add initial concentration (may be derived from initial count if necessary)
        SpeciesContextSpecParameter initConcParm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
        if (initConcParm != null) {
            Expression initConcExpr = null;
            if (initConcParm.getExpression() != null) {
                initConcExpr = new Expression(initConcParm.getExpression());
            } else if (initCountParm != null && initCountParm.getExpression() != null) {
                Expression structureSizeExpr = new Expression(speciesContext.getStructure().getStructureSize(), getNameScope());
                VCUnitDefinition concUnit = initConcParm.getUnitDefinition();
                VCUnitDefinition countDensityUnit = initCountParm.getUnitDefinition().divideBy(speciesContext.getStructure().getStructureSize().getUnitDefinition());
                Expression unitFactor = getUnitFactor(concUnit.divideBy(countDensityUnit));
                initConcExpr = Expression.mult(Expression.div(new Expression(initCountParm, getNameScope()), structureSizeExpr), unitFactor);
            }
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContext.getStructure());
            String[] symbols = initConcExpr.getSymbols();
            // Check if 'initExpr' has other speciesContexts in its expression, need to replace it with 'spContext_init'
            for (int j = 0; symbols != null && j < symbols.length; j++) {
                // if symbol is a speciesContext, replacing it with a reference to initial condition for that speciesContext.
                SpeciesContext spC = null;
                SymbolTableEntry ste = initConcExpr.getSymbolBinding(symbols[j]);
                if (ste == null) {
                    String msg = initConcParm.getName() == null ? "??" : initConcParm.getName();
                    System.out.println("Unexpected NULL symbol in the initial expression of " + msg);
                } else if (ste instanceof SpeciesContextSpecProxyParameter) {
                    SpeciesContextSpecProxyParameter spspp = (SpeciesContextSpecProxyParameter) ste;
                    if (spspp.getTarget() instanceof SpeciesContext) {
                        spC = (SpeciesContext) spspp.getTarget();
                        SpeciesContextSpec spcspec = simContext.getReactionContext().getSpeciesContextSpec(spC);
                        SpeciesContextSpecParameter spCInitParm = spcspec.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
                        // if initConc param expression is null, try initCount
                        if (spCInitParm.getExpression() == null) {
                            spCInitParm = spcspec.getParameterFromRole(SpeciesContextSpec.ROLE_InitialCount);
                        }
                        // need to get init condn expression, but can't get it from getMathSymbol() (mapping between bio and math), hence get it as below.
                        Expression scsInitExpr = new Expression(spCInitParm, getNameScope());
                        initConcExpr.substituteInPlace(new Expression(spC.getName()), scsInitExpr);
                    }
                } else if (ste instanceof ModelParameter) {
                    ModelParameter mpArg = (ModelParameter) ste;
                    System.out.println(mpArg.getName());
                    if (simContext.getRateRule(mpArg) == null) {
                        // only globals that are RateRule variables need to be replaced with their _init variable
                        continue;
                    }
                    EventAssignmentOrRateRuleInitParameter mpInitParam = modelParamTorateRuleInitMapping.get(mpArg);
                    if (mpInitParam != null) {
                        // we already made it, we only need to use it
                        Expression mpArgInitExpr = new Expression(mpInitParam, getNameScope());
                        initConcExpr.substituteInPlace(new Expression(ste.getName()), mpArgInitExpr);
                    }
                } else {
                    String msg = ste.getName() == null ? "??" : ste.getName();
                    String msg2 = initConcParm.getName() == null ? "??" : initConcParm.getName();
                    System.out.println("Unexpected symbol type for " + msg + " in the initial expression of " + msg2);
                }
            }
            // now create the appropriate function for the current speciesContextSpec.
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(initConcParm, sm.getGeometryClass()), getIdentifierSubstitutions(initConcExpr, initConcParm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextMapping scm = getSpeciesContextMapping(speciesContextSpecs[i].getSpeciesContext());
        SpeciesContextSpec.SpeciesContextSpecParameter diffParm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_DiffusionRate);
        if (diffParm != null && (scm.isPDERequired())) {
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(diffParm, sm.getGeometryClass()), getIdentifierSubstitutions(diffParm.getExpression(), diffParm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextSpec.SpeciesContextSpecParameter bc_xm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueXm);
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
        if (bc_xm != null && (bc_xm.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_xm, sm.getGeometryClass()), getIdentifierSubstitutions(bc_xm.getExpression(), bc_xm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_xp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueXp);
        if (bc_xp != null && (bc_xp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_xp, sm.getGeometryClass()), getIdentifierSubstitutions(bc_xp.getExpression(), bc_xp.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_ym = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueYm);
        if (bc_ym != null && (bc_ym.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_ym, sm.getGeometryClass()), getIdentifierSubstitutions(bc_ym.getExpression(), bc_ym.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_yp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueYp);
        if (bc_yp != null && (bc_yp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_yp, sm.getGeometryClass()), getIdentifierSubstitutions(bc_yp.getExpression(), bc_yp.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_zm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueZm);
        if (bc_zm != null && (bc_zm.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_zm, sm.getGeometryClass()), getIdentifierSubstitutions(bc_zm.getExpression(), bc_zm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_zp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueZp);
        if (bc_zp != null && (bc_zp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_zp, sm.getGeometryClass()), getIdentifierSubstitutions(bc_zp.getExpression(), bc_zp.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velX = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityX);
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
        GeometryClass geometryClass = sm.getGeometryClass();
        if (advection_velX != null && (advection_velX.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velX, geometryClass), getIdentifierSubstitutions(advection_velX.getExpression(), advection_velX.getUnitDefinition(), geometryClass), geometryClass));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velY = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityY);
        if (advection_velY != null && (advection_velY.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velY, geometryClass), getIdentifierSubstitutions(advection_velY.getExpression(), advection_velY.getUnitDefinition(), geometryClass), geometryClass));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velZ = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityZ);
        if (advection_velZ != null && (advection_velZ.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velZ, geometryClass), getIdentifierSubstitutions(advection_velZ.getExpression(), advection_velZ.getUnitDefinition(), geometryClass), geometryClass));
        }
    }
    // 
    // constant species (either function or constant)
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof Constant) {
            varHash.addVariable(scm.getVariable());
        }
    }
    // 
    // conversion factors
    // 
    varHash.addVariable(new Constant(model.getKMOLE().getName(), getIdentifierSubstitutions(model.getKMOLE().getExpression(), model.getKMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getN_PMOLE().getName(), getIdentifierSubstitutions(model.getN_PMOLE().getExpression(), model.getN_PMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getKMILLIVOLTS().getName(), getIdentifierSubstitutions(model.getKMILLIVOLTS().getExpression(), model.getKMILLIVOLTS().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getK_GHK().getName(), getIdentifierSubstitutions(model.getK_GHK().getExpression(), model.getK_GHK().getUnitDefinition(), null)));
    // 
    for (int i = 0; i < structureMappings.length; i++) {
        StructureMapping sm = structureMappings[i];
        if (simContext.getGeometry().getDimension() == 0) {
            StructureMappingParameter sizeParm = sm.getSizeParameter();
            if (sizeParm != null && sizeParm.getExpression() != null) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(sizeParm, sm.getGeometryClass()), getIdentifierSubstitutions(sizeParm.getExpression(), sizeParm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
            } else {
                if (sm instanceof MembraneMapping) {
                    MembraneMapping mm = (MembraneMapping) sm;
                    StructureMappingParameter volFrac = mm.getVolumeFractionParameter();
                    if (volFrac != null && volFrac.getExpression() != null) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(volFrac, sm.getGeometryClass()), getIdentifierSubstitutions(volFrac.getExpression(), volFrac.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
                    }
                    StructureMappingParameter surfToVol = mm.getSurfaceToVolumeParameter();
                    if (surfToVol != null && surfToVol.getExpression() != null) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(surfToVol, sm.getGeometryClass()), getIdentifierSubstitutions(surfToVol.getExpression(), surfToVol.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
                    }
                }
            }
        } else {
            Parameter parm = sm.getParameterFromRole(StructureMapping.ROLE_AreaPerUnitArea);
            if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SurfaceClass) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm.getGeometryClass()), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
            }
            parm = sm.getParameterFromRole(StructureMapping.ROLE_AreaPerUnitVolume);
            if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm.getGeometryClass()), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
            }
            parm = sm.getParameterFromRole(StructureMapping.ROLE_VolumePerUnitArea);
            if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SurfaceClass) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm.getGeometryClass()), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
            }
            parm = sm.getParameterFromRole(StructureMapping.ROLE_VolumePerUnitVolume);
            if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm.getGeometryClass()), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
            }
        }
        StructureMappingParameter sizeParm = sm.getSizeParameter();
        if (sm.getGeometryClass() != null && sizeParm != null) {
            if (simContext.getGeometry().getDimension() == 0) {
                if (sizeParm.getExpression() != null) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(sizeParm, sm.getGeometryClass()), getIdentifierSubstitutions(sizeParm.getExpression(), sizeParm.getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass()));
                }
            } else {
                String compartmentName = sm.getGeometryClass().getName();
                VCUnitDefinition sizeUnit = sm.getSizeParameter().getUnitDefinition();
                String sizeFunctionName = null;
                if (sm instanceof MembraneMapping) {
                    MembraneMapping mm = (MembraneMapping) sm;
                    if (mm.getGeometryClass() instanceof SurfaceClass) {
                        sizeFunctionName = MathFunctionDefinitions.Function_regionArea_current.getFunctionName();
                    } else if (mm.getGeometryClass() instanceof SubVolume) {
                        sizeFunctionName = MathFunctionDefinitions.Function_regionVolume_current.getFunctionName();
                    }
                } else if (sm instanceof FeatureMapping) {
                    sizeFunctionName = MathFunctionDefinitions.Function_regionVolume_current.getFunctionName();
                } else {
                    throw new RuntimeException("structure mapping " + sm.getClass().getName() + " not yet supported");
                }
                Expression totalVolumeCorrection = sm.getStructureSizeCorrection(simContext, this);
                Expression sizeFunctionExpression = Expression.function(sizeFunctionName, new Expression[] { new Expression("'" + compartmentName + "'") });
                // sizeFunctionExpression.bindExpression(mathDesc);
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(sizeParm, sm.getGeometryClass()), getIdentifierSubstitutions(Expression.mult(totalVolumeCorrection, sizeFunctionExpression), sizeUnit, sm.getGeometryClass()), sm.getGeometryClass()));
            }
        }
    }
    // 
    // functions
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() == null && scm.getDependencyExpression() != null) {
            // check if speciesContext has a rateRule; then the speciesContext should not be added as a constant
            if (simContext.getRateRule(scm.getSpeciesContext()) == null) {
                StructureMapping sm = simContext.getGeometryContext().getStructureMapping(scm.getSpeciesContext().getStructure());
                if (sm.getGeometryClass() == null) {
                    Structure s = sm.getStructure();
                    if (s != null) {
                        throw new RuntimeException("unmapped structure " + s.getName());
                    }
                    throw new RuntimeException("structure mapping with no structure or mapping");
                }
                Variable dependentVariable = newFunctionOrConstant(getMathSymbol(scm.getSpeciesContext(), sm.getGeometryClass()), getIdentifierSubstitutions(scm.getDependencyExpression(), scm.getSpeciesContext().getUnitDefinition(), sm.getGeometryClass()), sm.getGeometryClass());
                dependentVariable.setDomain(new Domain(sm.getGeometryClass()));
                varHash.addVariable(dependentVariable);
            }
        }
    }
    BioEvent[] bioevents = simContext.getBioEvents();
    if (bioevents != null && bioevents.length > 0) {
        for (BioEvent be : bioevents) {
            // transform the bioEvent trigger/delay to math Event
            for (LocalParameter p : be.getEventParameters()) {
                if (p.getExpression() != null) {
                    // ex: eventName.delay and eventName.triggerFunction
                    String name = getMathSymbol(p, null);
                    Expression exp = getIdentifierSubstitutions(p.getExpression(), p.getUnitDefinition(), null);
                    Variable var = newFunctionOrConstant(name, exp, null);
                    varHash.addVariable(var);
                } else if (be.getParameter(BioEventParameterType.GeneralTriggerFunction) == p) {
                    // 
                    // use generated function here.
                    // 
                    String name = getMathSymbol(p, null);
                    Expression exp = getIdentifierSubstitutions(be.generateTriggerExpression(), p.getUnitDefinition(), null);
                    Variable var = newFunctionOrConstant(name, exp, null);
                    varHash.addVariable(var);
                }
            }
        }
    }
    // 
    // substitute init functions for event assignment variables
    // 
    // for (Map.Entry<VolVariable,EventAssignmentOrRateRuleInitParameter> entry : eventVolVarHash.entrySet()) {
    // EventAssignmentOrRateRuleInitParameter eap = entry.getValue();
    // 
    // String argName = eap.getName();
    // Expression modelParamExpr = eap.getExpression();
    // GeometryClass gc = getDefaultGeometryClass(modelParamExpr);
    // VCUnitDefinition paramUnit = eap.getUnitDefinition();
    // Expression mpInitExpr = new Expression(modelParamExpr);
    // String[] symbols = mpInitExpr.getSymbols();
    // if(symbols == null || symbols.length == 0) {
    // continue;
    // }
    // // TODO: this is still not working well
    // // check if 'initExpr' has other speciesContexts or rate rule global parameter variables in its expression
    // // need to replace it with 'spContext_init', modelParameter_init
    // for (String symbol : symbols) {
    // // if symbol is a speciesContext, replacing it with a reference to initial condition for that speciesContext.
    // SymbolTableEntry ste = mpInitExpr.getSymbolBinding(symbol);
    // if (ste == null) {
    // System.out.println("Unexpected NULL symbol in the initial expression of " + argName);
    // } else if (ste instanceof SpeciesContext) {
    // SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec((SpeciesContext)ste);
    // // TODO: what if initial count???
    // SpeciesContextSpecParameter spCInitParm = scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
    // // need to get init condn expression, but can't get it from getMathSymbol() (mapping between bio and math), hence get it as below.
    // Expression scsInitExpr = new Expression(spCInitParm, getNameScope());
    // mpInitExpr.substituteInPlace(new Expression(ste.getName()), scsInitExpr);
    // } else if(ste instanceof ModelParameter) {
    // ModelParameter mpArg = (ModelParameter)ste;
    // System.out.println(mpArg.getName());
    // if(simContext.getRateRule(mpArg) == null) {
    // continue;		// only globals that are RateRule variables need to be replaced with their _init variable
    // }
    // Variable mpArgVar = initModelParameterHashTmp.get(mpArg);
    // if(mpArgVar != null && eventVolVarHash.get(mpArgVar) != null) {
    // EventAssignmentOrRateRuleInitParameter mpInitParam = eventVolVarHash.get(mpArgVar);
    // Expression mpArgInitExpr = new Expression(mpInitParam, getNameScope());
    // mpInitExpr.substituteInPlace(new Expression(ste.getName()), mpArgInitExpr);
    // 
    // }
    // } else {
    // String msg = ste.getName() == null ? "??" : ste.getName();
    // System.out.println("Unexpected symbol type for " + msg + " in the initial expression of " + argName);
    // }
    // }
    // varHash.removeVariable(argName);
    // Expression exp = getIdentifierSubstitutions(mpInitExpr, paramUnit, gc);
    // Variable varInit = newFunctionOrConstant(argName, exp, gc);
    // varHash.addVariable(varInit);
    // }
    // 
    // deal with rate rules
    // 
    // first, substitute the init functions for rate rule variables that are model parameters
    // we'll need this init variable (function or constant) for the ODE Equation
    // 
    // here we store the init variable with the final substitutions within their expressions
    Map<ModelParameter, Variable> initModelParameterHash = new HashMap<>();
    Map<String, SymbolTableEntry> entryMap = new HashMap<String, SymbolTableEntry>();
    simContext.getEntries(entryMap);
    for (Map.Entry<ModelParameter, Variable> entry : initModelParameterHashTmp.entrySet()) {
        ModelParameter mp = entry.getKey();
        Variable mpInitVariable = entry.getValue();
        String argName = mpInitVariable.getName();
        Expression modelParamExpr = mp.getExpression();
        GeometryClass gc = getDefaultGeometryClass(modelParamExpr);
        Expression mpInitExpr = new Expression(modelParamExpr);
        String[] symbols = mpInitExpr.getSymbols();
        if (symbols == null || symbols.length == 0) {
            // stays as it is in variable hash
            // we just move it into the initModelParameterHash
            initModelParameterHash.put(mp, mpInitVariable);
            continue;
        }
        // need to replace it with 'spContext_init', modelParameter_init
        for (String symbol : symbols) {
            // if symbol is a speciesContext, replacing it with a reference to initial condition for that speciesContext.
            SymbolTableEntry ste = mpInitExpr.getSymbolBinding(symbol);
            if (ste == null) {
                System.out.println("Unexpected NULL symbol in the initial expression of " + argName);
            } else if (ste instanceof SpeciesContext) {
                SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec((SpeciesContext) ste);
                // TODO: what if initial count???
                SpeciesContextSpecParameter spCInitParm = scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
                // need to get init condn expression, but can't get it from getMathSymbol() (mapping between bio and math), hence get it as below.
                Expression scsInitExpr = new Expression(spCInitParm, getNameScope());
                mpInitExpr.substituteInPlace(new Expression(ste.getName()), scsInitExpr);
            } else if (ste instanceof ModelParameter) {
                ModelParameter mpArg = (ModelParameter) ste;
                System.out.println(mpArg.getName());
                if (simContext.getRateRule(mpArg) == null) {
                    // only globals that are RateRule variables need to be replaced with their _init variable
                    continue;
                }
                EventAssignmentOrRateRuleInitParameter mpInitParam = modelParamTorateRuleInitMapping.get(mpArg);
                if (mpInitParam != null) {
                    // we already made it, we only need to use it
                    Expression mpArgInitExpr = new Expression(mpInitParam, getNameScope());
                    mpInitExpr.substituteInPlace(new Expression(ste.getName()), mpArgInitExpr);
                }
            } else {
                String msg = ste.getName() == null ? "??" : ste.getName();
                System.out.println("Unexpected symbol type for " + msg + " in the initial expression of " + argName);
            }
        }
        VCUnitDefinition paramUnit = modelUnitSystem.getInstance_TBD();
        if (mp.getUnitDefinition() != null && !mp.getUnitDefinition().equals(modelUnitSystem.getInstance_TBD())) {
            paramUnit = mp.getUnitDefinition();
        }
        varHash.removeVariable(mpInitVariable);
        Expression exp = getIdentifierSubstitutions(mpInitExpr, paramUnit, gc);
        mpInitVariable = newFunctionOrConstant(argName, exp, gc);
        varHash.addVariable(mpInitVariable);
        initModelParameterHash.put(mp, mpInitVariable);
    }
    // 
    // create the VolVariable for the species context used as rate rule variable
    // create the Variable (function or constant) for its rate (need it for the ODE Equation)
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        // species context used as rate rule variable
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        Variable var = scm.getVariable();
        Expression exp = scm.getDependencyExpression();
        if (var == null && exp != null) {
            RateRule rr = simContext.getRateRule(scm.getSpeciesContext());
            if (rr != null && (rr.getRateRuleVar() instanceof SpeciesContext)) {
                SpeciesContext sc = scm.getSpeciesContext();
                StructureMapping sm = simContext.getGeometryContext().getStructureMapping(sc.getStructure());
                if (sm.getGeometryClass() == null) {
                    Structure s = sm.getStructure();
                    if (s != null) {
                        throw new RuntimeException("unmapped structure " + s.getName());
                    }
                    throw new RuntimeException("structure mapping with no structure or mapping");
                }
                String name = getMathSymbol(scm.getSpeciesContext(), sm.getGeometryClass());
                Expression orig = rr.getRateRuleExpression();
                Expression ex = getIdentifierSubstitutions(orig, scm.getSpeciesContext().getUnitDefinition(), sm.getGeometryClass());
                GeometryClass gc = sm.getGeometryClass();
                Domain domain = null;
                if (gc != null) {
                    domain = new Domain(gc);
                }
                if (gc instanceof SurfaceClass) {
                    scm.setVariable(new MemVariable(scm.getSpeciesContext().getName(), domain));
                } else {
                    scm.setVariable(new VolVariable(scm.getSpeciesContext().getName(), domain));
                }
                Variable oldVariablre = varHash.getVariable(name);
                if (oldVariablre != null) {
                    // should always be null
                    varHash.removeVariable(name);
                }
                varHash.addVariable(scm.getVariable());
                // // create the rate parameter
                SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
                SpeciesContextSpecParameter scsInitParam = scs.getInitialConditionParameter();
                VCUnitDefinition scsInitParamUnit = scsInitParam.getUnitDefinition();
                RateRuleRateParameter rateParam = null;
                try {
                    Expression origExp = simContext.getRateRule(sc).getRateRuleExpression();
                    VCUnitDefinition rateUnit = modelUnitSystem.getInstance_TBD();
                    if (scsInitParamUnit != null && !scsInitParamUnit.equals(modelUnitSystem.getInstance_TBD())) {
                        rateUnit = scsInitParamUnit;
                    }
                    Expression rateExpr = getIdentifierSubstitutions(origExp, rateUnit, gc);
                    String argName = sc.getName() + MATH_FUNC_SUFFIX_RATERULE_RATE;
                    Variable param = newFunctionOrConstant(argName, rateExpr, gc);
                    varHash.addVariable(param);
                    rateParam = addRateRuleRateParameter(sc, rateExpr, PARAMETER_ROLE_RATERULE_RATE, rateUnit);
                } catch (PropertyVetoException e) {
                    e.printStackTrace(System.out);
                    throw new MappingException(e.getMessage());
                }
                // we generate the ODE equation elsewhere (later)
                rateRuleRateParamHash.put(scm.getVariable(), rateParam);
            }
        } else if (var != null && exp == null) {
            // could be an event variable AND a rate rule variable - in which case we need a rate parameter for the event ODE equation
            SpeciesContext sc = scm.getSpeciesContext();
            boolean isRateRuleVar = rateRuleVarTargets.contains(sc);
            boolean isEventAssignVar = eventAssignTargets.contains(sc);
            if (isRateRuleVar && isEventAssignVar) {
                // is both, so we make a rate parameter, like above
                SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
                SpeciesContextSpecParameter scsInitParam = scs.getInitialConditionParameter();
                VCUnitDefinition scsInitParamUnit = scsInitParam.getUnitDefinition();
                StructureMapping sm = simContext.getGeometryContext().getStructureMapping(sc.getStructure());
                GeometryClass gc = sm.getGeometryClass();
                RateRuleRateParameter rateParam = null;
                try {
                    Expression origExp = simContext.getRateRule(sc).getRateRuleExpression();
                    VCUnitDefinition rateUnit = modelUnitSystem.getInstance_TBD();
                    if (scsInitParamUnit != null && !scsInitParamUnit.equals(modelUnitSystem.getInstance_TBD())) {
                        rateUnit = scsInitParamUnit;
                    }
                    Expression rateExpr = getIdentifierSubstitutions(origExp, rateUnit, gc);
                    String argName = sc.getName() + MATH_FUNC_SUFFIX_RATERULE_RATE;
                    Variable param = newFunctionOrConstant(argName, rateExpr, gc);
                    varHash.addVariable(param);
                    rateParam = addRateRuleRateParameter(sc, rateExpr, PARAMETER_ROLE_RATERULE_RATE, rateUnit);
                } catch (PropertyVetoException e) {
                    e.printStackTrace(System.out);
                    throw new MappingException(e.getMessage());
                }
                // we generate the ODE equation elsewhere (later)
                rateRuleRateParamHash.put(var, rateParam);
            }
        }
    }
    // 
    for (ModelParameter mp : modelParameters) {
        // global parameter used as rate rule variable
        Variable var = varHash.getVariable(mp.getName());
        RateRule rr = simContext.getRateRule(mp);
        Expression modelParamExpr = mp.getExpression();
        if (var == null && rr != null) {
            // at this point var should be a constant
            // we're under the assumption that it's non-spatial
            GeometryClass[] geometryClasses = simContext.getGeometryContext().getGeometry().getGeometryClasses();
            GeometryClass gc = geometryClasses[0];
            // SubDomain subDomain = mathDesc.getSubDomains().nextElement();
            // GeometryClass gc = getDefaultGeometryClass(modelParamExpr);
            Domain domain = null;
            if (gc != null) {
                domain = new Domain(gc);
            }
            Variable variable;
            if (gc instanceof SurfaceClass) {
                variable = new MemVariable(mp.getName(), domain);
            } else {
                variable = new VolVariable(mp.getName(), domain);
            }
            varHash.addVariable(variable);
            RateRuleRateParameter rateParam = null;
            try {
                Expression origExp = rr.getRateRuleExpression();
                VCUnitDefinition rateUnit = modelUnitSystem.getInstance_TBD();
                if (mp.getUnitDefinition() != null && !mp.getUnitDefinition().equals(modelUnitSystem.getInstance_TBD())) {
                    rateUnit = mp.getUnitDefinition().divideBy(timeUnit);
                }
                Expression rateExpr = getIdentifierSubstitutions(origExp, rateUnit, gc);
                String argName = mp.getName() + MATH_FUNC_SUFFIX_RATERULE_RATE;
                Variable param = newFunctionOrConstant(argName, rateExpr, gc);
                varHash.addVariable(param);
                rateParam = addRateRuleRateParameter(mp, rateExpr, PARAMETER_ROLE_RATERULE_RATE, rateUnit);
            } catch (PropertyVetoException e) {
                e.printStackTrace(System.out);
                throw new MappingException(e.getMessage());
            }
            // no need to put it in the hash, we make the ODE Equation right here
            // rateRuleRateParamHash.put(variable, rateParam);
            // we know it's non-spatial
            SubDomain subDomain = mathDesc.getSubDomains().nextElement();
            Equation equation = null;
            // TODO: replace the expression with the variable  ex: "g0_protocol_init" computed above
            Expression initial = new Expression(mp.getExpression());
            // TODO: can it be null? should check and maybe try mp.getConstantValue() too ???
            Variable mpInitVariable = initModelParameterHash.get(mp);
            if (mpInitVariable != null) {
                initial = new Expression(mpInitVariable.getName());
            }
            Expression rateExpr = new Expression(0.0);
            // RateRuleRateParameter rateParam = rateRuleRateParamHash.get(variable);
            if (rateParam != null) {
                // ex: g0_rate
                rateExpr = new Expression(getMathSymbol(rateParam, gc));
            }
            // ODE Equation for rate rule variable being a global parameter
            equation = new OdeEquation(variable, initial, rateExpr);
            subDomain.addEquation(equation);
        }
    }
    // 
    // deal with assignment rules
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        // species context used as assignment rule variable
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() == null && scm.getDependencyExpression() != null) {
            AssignmentRule ar = simContext.getAssignmentRule(scm.getSpeciesContext());
            if (ar != null && (ar.getAssignmentRuleVar() instanceof SpeciesContext)) {
                // TODO: we limit assignment rules to SpeciesContext for now
                StructureMapping sm = simContext.getGeometryContext().getStructureMapping(scm.getSpeciesContext().getStructure());
                if (sm.getGeometryClass() == null) {
                    Structure s = sm.getStructure();
                    if (s != null) {
                        throw new RuntimeException("unmapped structure " + s.getName());
                    }
                    throw new RuntimeException("structure mapping with no structure or mapping");
                }
                String name = getMathSymbol(scm.getSpeciesContext(), sm.getGeometryClass());
                Expression orig = ar.getAssignmentRuleExpression();
                Expression ex = getIdentifierSubstitutions(orig, scm.getSpeciesContext().getUnitDefinition(), sm.getGeometryClass());
                GeometryClass gc = sm.getGeometryClass();
                Variable dependentVariable = newFunctionOrConstant(name, ex, gc);
                dependentVariable.setDomain(new Domain(sm.getGeometryClass()));
                varHash.removeVariable(name);
                varHash.addVariable(dependentVariable);
            }
        }
    }
    for (ModelParameter mp : modelParameters) {
        // global parameter used as assignment rule variable
        Variable var = varHash.getVariable(mp.getName());
        AssignmentRule ar = simContext.getAssignmentRule(mp);
        Expression modelParamExpr = mp.getExpression();
        if (var == null && ar != null) {
            // at this point var (global parameter used as assignment rule variable) should be null
            // we're under the assumption that it's non-spatial
            GeometryClass[] geometryClasses = simContext.getGeometryContext().getGeometry().getGeometryClasses();
            GeometryClass gc = geometryClasses[0];
            SubDomain subDomain = mathDesc.getSubDomains().nextElement();
            Expression origExp = ar.getAssignmentRuleExpression();
            VCUnitDefinition rateUnit = modelUnitSystem.getInstance_TBD();
            if (mp.getUnitDefinition() != null && !mp.getUnitDefinition().equals(modelUnitSystem.getInstance_TBD())) {
                rateUnit = mp.getUnitDefinition();
            }
            Expression rateExpr = getIdentifierSubstitutions(origExp, rateUnit, gc);
            String argName = mp.getName();
            Variable param = newFunctionOrConstant(argName, rateExpr, gc);
            varHash.addVariable(param);
        }
    }
    // 
    // set Variables to MathDescription all at once with the order resolved by "VariableHash"
    // 
    mathDesc.setAllVariables(varHash.getAlphabeticallyOrderedVariables());
    // 
    if (simContext.getGeometryContext().getGeometry() != null) {
        try {
            mathDesc.setGeometry(simContext.getGeometryContext().getGeometry());
        } catch (java.beans.PropertyVetoException e) {
            e.printStackTrace(System.out);
            throw new MappingException("failure setting geometry " + e.getMessage());
        }
    } else {
        throw new MappingException("geometry must be defined");
    }
    // 
    for (CompartmentSubdomainContext compartmentSubDomainContext : compartmentSubdomainContexts) {
        SubVolume subVolume = compartmentSubDomainContext.subvolume;
        CompartmentSubDomain subDomain = mathDesc.getCompartmentSubDomain(subVolume.getName());
        // 
        // assign boundary condition types
        // 
        StructureMapping[] mappedSMs = simContext.getGeometryContext().getStructureMappings(subVolume);
        FeatureMapping mappedFM = null;
        for (int i = 0; i < mappedSMs.length; i++) {
            if (mappedSMs[i] instanceof FeatureMapping) {
                if (mappedFM != null) {
                    lg.warn("WARNING:::: MathMapping.refreshMathDescription() ... assigning boundary condition types not unique");
                }
                mappedFM = (FeatureMapping) mappedSMs[i];
            }
        }
        if (mappedFM != null) {
            if (simContext.getGeometry().getDimension() > 0) {
                subDomain.setBoundaryConditionXm(mappedFM.getBoundaryConditionTypeXm());
                subDomain.setBoundaryConditionXp(mappedFM.getBoundaryConditionTypeXp());
            }
            if (simContext.getGeometry().getDimension() > 1) {
                subDomain.setBoundaryConditionYm(mappedFM.getBoundaryConditionTypeYm());
                subDomain.setBoundaryConditionYp(mappedFM.getBoundaryConditionTypeYp());
            }
            if (simContext.getGeometry().getDimension() > 2) {
                subDomain.setBoundaryConditionZm(mappedFM.getBoundaryConditionTypeZm());
                subDomain.setBoundaryConditionZp(mappedFM.getBoundaryConditionTypeZp());
            }
        }
        // 
        // create equations
        // 
        VolumeStructureAnalyzer structureAnalyzer = getVolumeStructureAnalyzer(subVolume);
        Enumeration<SpeciesContextMapping> enumSCM = getSpeciesContextMappings();
        while (enumSCM.hasMoreElements()) {
            SpeciesContextMapping scm = enumSCM.nextElement();
            SpeciesContext sc = scm.getSpeciesContext();
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(sc.getStructure());
            SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
            // 
            // if an independent volume variable, then create equation for it (if mapped to this subDomain)
            // 
            final GeometryClass gc = sm.getGeometryClass();
            if (gc == null || !gc.getName().equals(subDomain.getName())) {
                continue;
            }
            SpeciesContextSpecParameter initConcParameter = scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
            if ((scm.getVariable() instanceof VolumeRegionVariable) && scm.getDependencyExpression() == null) {
                VolumeRegionVariable volumeRegionVariable = (VolumeRegionVariable) scm.getVariable();
                Expression initial = getIdentifierSubstitutions(new Expression(initConcParameter, getNameScope()), initConcParameter.getUnitDefinition(), sm.getGeometryClass());
                Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                VolumeRegionEquation volumeRegionEquation = new VolumeRegionEquation(volumeRegionVariable, initial);
                volumeRegionEquation.setVolumeRateExpression(rate);
                subDomain.addEquation(volumeRegionEquation);
            } else if (scm.getVariable() instanceof VolVariable && scm.getDependencyExpression() == null) {
                VolVariable variable = (VolVariable) scm.getVariable();
                Equation equation = null;
                if (sm.getGeometryClass() == subVolume) {
                    if (scm.isPDERequired()) {
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = getIdentifierSubstitutions(new Expression(initConcParameter, getNameScope()), initConcParameter.getUnitDefinition(), sm.getGeometryClass());
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                        SpeciesContextSpecParameter diffusionParameter = scs.getDiffusionParameter();
                        Expression diffusion = getIdentifierSubstitutions(new Expression(diffusionParameter, getNameScope()), diffusionParameter.getUnitDefinition(), sm.getGeometryClass());
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        ((PdeEquation) equation).setBoundaryXm((scs.getBoundaryXmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryXp((scs.getBoundaryXpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXpParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryYm((scs.getBoundaryYmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryYp((scs.getBoundaryYpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYpParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryZm((scs.getBoundaryZmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryZp((scs.getBoundaryZpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZpParameter(), sm.getGeometryClass())));
                        if (simContext.getGeometry().getDimension() >= 1) {
                            Expression velXExp = null;
                            if (scs.getVelocityXParameter().getExpression() != null) {
                                velXExp = new Expression(getMathSymbol(scs.getVelocityXParameter(), sm.getGeometryClass()));
                            } else {
                                SpatialQuantity[] velX_quantities = scs.getVelocityQuantities(QuantityComponent.X);
                                if (velX_quantities.length > 0) {
                                    int numRegions = simContext.getGeometry().getGeometrySurfaceDescription().getGeometricRegions(subVolume).length;
                                    if (velX_quantities.length == 1 && numRegions == 1) {
                                        velXExp = new Expression(getMathSymbol(velX_quantities[0], sm.getGeometryClass()));
                                    } else {
                                        throw new MappingException("multiple advection velocities enabled set for multiple volume domains ");
                                    }
                                }
                            }
                            ((PdeEquation) equation).setVelocityX(velXExp);
                        }
                        if (simContext.getGeometry().getDimension() >= 2) {
                            Expression velYExp = null;
                            if (scs.getVelocityYParameter().getExpression() != null) {
                                velYExp = new Expression(getMathSymbol(scs.getVelocityYParameter(), sm.getGeometryClass()));
                            } else {
                                SpatialQuantity[] velY_quantities = scs.getVelocityQuantities(QuantityComponent.Y);
                                if (velY_quantities.length > 0) {
                                    int numRegions = simContext.getGeometry().getGeometrySurfaceDescription().getGeometricRegions(subVolume).length;
                                    if (velY_quantities.length == 1 && numRegions == 1) {
                                        velYExp = new Expression(getMathSymbol(velY_quantities[0], sm.getGeometryClass()));
                                    } else {
                                        throw new MappingException("multiple advection velocities enabled set for multiple volume domains ");
                                    }
                                }
                            }
                            ((PdeEquation) equation).setVelocityY(velYExp);
                        }
                        if (simContext.getGeometry().getDimension() == 3) {
                            Expression velZExp = null;
                            if (scs.getVelocityZParameter().getExpression() != null) {
                                velZExp = new Expression(getMathSymbol(scs.getVelocityZParameter(), sm.getGeometryClass()));
                            } else {
                                SpatialQuantity[] velZ_quantities = scs.getVelocityQuantities(QuantityComponent.Z);
                                if (velZ_quantities.length > 0) {
                                    int numRegions = simContext.getGeometry().getGeometrySurfaceDescription().getGeometricRegions(subVolume).length;
                                    if (velZ_quantities.length == 1 && numRegions == 1) {
                                        velZExp = new Expression(getMathSymbol(velZ_quantities[0], sm.getGeometryClass()));
                                    } else {
                                        throw new MappingException("multiple advection velocities enabled set for multiple volume domains ");
                                    }
                                }
                            }
                            ((PdeEquation) equation).setVelocityZ(velZExp);
                        }
                        subDomain.replaceEquation(equation);
                    } else {
                        // 
                        // ODE - species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(initConcParameter, null));
                        Expression rate = (scm.getRate() == null) ? new Expression(0.0) : getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                        // 
                        // if it's an event assignment variable AND a rate rule variable
                        // we replace the event rate computed above (which should be zero) with the RateRuleParameter expression
                        // 
                        RateRuleRateParameter rateParam = rateRuleRateParamHash.get(variable);
                        if (rateParam != null) {
                            rate = new Expression(getMathSymbol(rateParam, null));
                        }
                        equation = new OdeEquation(variable, initial, rate);
                        subDomain.replaceEquation(equation);
                    }
                }
            } else if (scm.getVariable() instanceof VolVariable && scm.getDependencyExpression() != null) {
                // rate rule variables are like this
                RateRule rr = simContext.getRateRule(scm.getSpeciesContext());
                if (rr != null && (rr.getRateRuleVar() instanceof SpeciesContext)) {
                    // 
                    // we generate rate rule ODE equation only for species variable that are NOT event assignment variable (see right above)
                    // for global parameters variable we do it elsewhere
                    // 
                    VolVariable variable = (VolVariable) scm.getVariable();
                    Equation equation = null;
                    if (sm.getGeometryClass() == subVolume) {
                        Expression initial = new Expression(getMathSymbol(initConcParameter, null));
                        Expression rateExpr = new Expression(0.0);
                        RateRuleRateParameter rateParam = rateRuleRateParamHash.get(variable);
                        if (rateParam != null) {
                            rateExpr = new Expression(getMathSymbol(rateParam, null));
                        }
                        equation = new OdeEquation(variable, initial, rateExpr);
                        subDomain.addEquation(equation);
                    }
                }
            }
        }
        // 
        // create fast system (if neccessary)
        // 
        SpeciesContextMapping[] fastSpeciesContextMappings = structureAnalyzer.getFastSpeciesContextMappings();
        if (fastSpeciesContextMappings != null) {
            FastSystem fastSystem = new FastSystem(mathDesc);
            for (int i = 0; i < fastSpeciesContextMappings.length; i++) {
                SpeciesContextMapping scm = fastSpeciesContextMappings[i];
                if (scm.getFastInvariant() == null) {
                    // 
                    // independant-fast variable, create a fastRate object
                    // 
                    Expression rate = getIdentifierSubstitutions(scm.getFastRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), subVolume);
                    FastRate fastRate = new FastRate(rate);
                    fastSystem.addFastRate(fastRate);
                } else {
                    // 
                    // dependant-fast variable, create a fastInvariant object
                    // 
                    Expression rate = getIdentifierSubstitutions(scm.getFastInvariant(), modelUnitSystem.getVolumeConcentrationUnit(), subVolume);
                    FastInvariant fastInvariant = new FastInvariant(rate);
                    fastSystem.addFastInvariant(fastInvariant);
                }
            }
            subDomain.setFastSystem(fastSystem);
            // constructor calls the 'refresh' method which constructs depemdency matrix, dependent/independent vars and pseudoconstants, etc.
            // FastSystemAnalyzer fs_analyzer =
            new FastSystemAnalyzer(fastSystem, mathDesc);
        }
        // 
        // create ode's for voltages to be calculated on unresolved membranes mapped to this subVolume
        // 
        Structure[] localStructures = simContext.getGeometryContext().getStructuresFromGeometryClass(subVolume);
        for (int sIndex = 0; sIndex < localStructures.length; sIndex++) {
            if (localStructures[sIndex] instanceof Membrane) {
                Membrane membrane = (Membrane) localStructures[sIndex];
                MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membrane);
                if ((membraneMapping.getGeometryClass() instanceof SubVolume) && membraneMapping.getCalculateVoltage()) {
                    MembraneElectricalDevice capacitiveDevice = potentialMapping.getCapacitiveDevice(membrane);
                    if (capacitiveDevice.getDependentVoltageExpression() == null) {
                        VolVariable vVar = (VolVariable) mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping.getGeometryClass()));
                        Expression initExp = new Expression(getMathSymbol(capacitiveDevice.getMembraneMapping().getInitialVoltageParameter(), membraneMapping.getGeometryClass()));
                        subDomain.addEquation(new OdeEquation(vVar, initExp, getIdentifierSubstitutions(potentialMapping.getOdeRHS(capacitiveDevice, this), membrane.getMembraneVoltage().getUnitDefinition().divideBy(timeUnit), membraneMapping.getGeometryClass())));
                    } else {
                    // 
                    // 
                    // 
                    }
                }
            }
        }
    }
    // 
    for (MembraneSubdomainContext memSubdomainContext : membraneSubdomainContexts) {
        MembraneSubDomain memSubDomain = memSubdomainContext.membraneSubdomain;
        SurfaceClass surfaceClass = memSubdomainContext.surfaceClass;
        for (SurfaceRegionObject surfaceRegionObject : memSubdomainContext.surfaceRegionObjects) {
            if (surfaceRegionObject.isQuantityCategoryEnabled(QuantityCategory.SurfaceVelocity)) {
                int dim = simContext.getGeometry().getDimension();
                if (dim != 2) {
                    throw new MappingException("Membrane Velocity only supported for 2D geometries");
                }
                if (simContext.getGeometry().getDimension() >= 1) {
                    SpatialQuantity velXQuantity = surfaceRegionObject.getSpatialQuantity(QuantityCategory.SurfaceVelocity, QuantityComponent.X);
                    Expression velXExp = new Expression(velXQuantity, simContext.getNameScope());
                    memSubDomain.setVelocityX(getIdentifierSubstitutions(velXExp, velXQuantity.getUnitDefinition(), surfaceClass));
                }
                if (simContext.getGeometry().getDimension() >= 2) {
                    SpatialQuantity velYQuantity = surfaceRegionObject.getSpatialQuantity(QuantityCategory.SurfaceVelocity, QuantityComponent.Y);
                    Expression velYExp = new Expression(velYQuantity, simContext.getNameScope());
                    memSubDomain.setVelocityY(getIdentifierSubstitutions(velYExp, velYQuantity.getUnitDefinition(), surfaceClass));
                }
                if (simContext.getGeometry().getDimension() == 3) {
                    SpatialQuantity velZQuantity = surfaceRegionObject.getSpatialQuantity(QuantityCategory.SurfaceVelocity, QuantityComponent.Z);
                    Expression velZExp = new Expression(velZQuantity, simContext.getNameScope());
                    // memSubDomain.setVelocityZ(getIdentifierSubstitutions(velZExp, velZQuantity.getUnitDefinition(), surfaceClass));
                    throw new MappingException("Membrane Velocity not supported for 2D problems");
                }
            }
        }
        // 
        // create equations for membrane-bound molecular species
        // 
        MembraneStructureAnalyzer membraneStructureAnalyzer = getMembraneStructureAnalyzer(surfaceClass);
        Enumeration<SpeciesContextMapping> enumSCM = getSpeciesContextMappings();
        while (enumSCM.hasMoreElements()) {
            SpeciesContextMapping scm = enumSCM.nextElement();
            SpeciesContext sc = scm.getSpeciesContext();
            SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(sc.getStructure());
            // 
            if ((scm.getVariable() instanceof MembraneRegionVariable) && scm.getDependencyExpression() == null) {
                MembraneRegionEquation equation = null;
                MembraneRegionVariable memRegionVar = (MembraneRegionVariable) scm.getVariable();
                if (sm.getGeometryClass() == surfaceClass) {
                    // 
                    // species context belongs to this subDomain
                    // 
                    Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), sm.getGeometryClass()));
                    Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                    equation = new MembraneRegionEquation(memRegionVar, initial);
                    equation.setMembraneRateExpression(rate);
                    // equation.setUniformRateExpression(newUniformRateExpression);
                    memSubDomain.replaceEquation(equation);
                }
            } else if ((scm.getVariable() instanceof MemVariable) && scm.getDependencyExpression() == null) {
                // 
                if (sm.getGeometryClass() == surfaceClass) {
                    Equation equation = null;
                    MemVariable variable = (MemVariable) scm.getVariable();
                    if (scm.isPDERequired()) {
                        // 
                        // PDE
                        // 
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), sm.getGeometryClass()));
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                        Expression diffusion = new Expression(getMathSymbol(scs.getDiffusionParameter(), sm.getGeometryClass()));
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        ((PdeEquation) equation).setBoundaryXm((scs.getBoundaryXmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryXp((scs.getBoundaryXpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXpParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryYm((scs.getBoundaryYmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryYp((scs.getBoundaryYpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYpParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryZm((scs.getBoundaryZmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZmParameter(), sm.getGeometryClass())));
                        ((PdeEquation) equation).setBoundaryZp((scs.getBoundaryZpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZpParameter(), sm.getGeometryClass())));
                        memSubDomain.replaceEquation(equation);
                    } else {
                        // 
                        // ODE
                        // 
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), null));
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()).getGeometryClass());
                        equation = new OdeEquation(variable, initial, rate);
                        memSubDomain.replaceEquation(equation);
                    }
                }
            }
        }
        Enumeration<SpeciesContextMapping> enum_scm = getSpeciesContextMappings();
        while (enum_scm.hasMoreElements()) {
            SpeciesContextMapping scm = enum_scm.nextElement();
            if (scm.isPDERequired() || scm.getVariable() instanceof VolumeRegionVariable) {
                // Species species = scm.getSpeciesContext().getSpecies();
                Variable var = scm.getVariable();
                final Domain dm = var.getDomain();
                if (dm != null) {
                    final String domainName = dm.getName();
                    if (sameName(domainName, memSubDomain.getInsideCompartment()) || sameName(domainName, memSubDomain.getOutsideCompartment())) {
                        JumpCondition jc = memSubDomain.getJumpCondition(var);
                        if (jc == null) {
                            // System.out.println("MathMapping.refreshMathDescription(), adding jump condition for diffusing variable "+var.getName()+" on membrane "+membraneStructureAnalyzer.getMembrane().getName());
                            if (var instanceof VolVariable) {
                                jc = new JumpCondition((VolVariable) var);
                            } else if (var instanceof VolumeRegionVariable) {
                                jc = new JumpCondition((VolumeRegionVariable) var);
                            } else {
                                throw new RuntimeException("unexpected Variable type " + var.getClass().getName());
                            }
                            memSubDomain.addJumpCondition(jc);
                        }
                    }
                }
            }
        }
        // 
        // set jump conditions for any volume variables or volume region variables that have explicitly defined fluxes
        // 
        ResolvedFlux[] resolvedFluxes = membraneStructureAnalyzer.getResolvedFluxes();
        if (resolvedFluxes != null) {
            for (int i = 0; i < resolvedFluxes.length; i++) {
                SpeciesContext sc = resolvedFluxes[i].getSpeciesContext();
                SpeciesContextMapping scm = getSpeciesContextMapping(sc);
                StructureMapping sm = getSimulationContext().getGeometryContext().getStructureMapping(sc.getStructure());
                if (scm.getVariable() instanceof VolVariable && scm.isPDERequired()) {
                    VolVariable volVar = (VolVariable) scm.getVariable();
                    JumpCondition jc = memSubDomain.getJumpCondition(volVar);
                    if (jc == null) {
                        jc = new JumpCondition(volVar);
                        memSubDomain.addJumpCondition(jc);
                    }
                    Expression flux = getIdentifierSubstitutions(resolvedFluxes[i].getFluxExpression(), resolvedFluxes[i].getUnitDefinition(), membraneStructureAnalyzer.getSurfaceClass());
                    if (memSubDomain.getInsideCompartment().getName().equals(sm.getGeometryClass().getName())) {
                        jc.setInFlux(flux);
                    } else if (memSubDomain.getOutsideCompartment().getName().equals(sm.getGeometryClass().getName())) {
                        jc.setOutFlux(flux);
                    } else {
                        throw new RuntimeException("Application  " + simContext.getName() + " : " + scm.getSpeciesContext().getName() + " has spatially resolved flux at membrane " + scm.getSpeciesContext().getStructure().getName() + " with a non-local flux species " + scm.getSpeciesContext().getName());
                    }
                } else if (scm.getVariable() instanceof VolumeRegionVariable) {
                    VolumeRegionVariable volRegionVar = (VolumeRegionVariable) scm.getVariable();
                    JumpCondition jc = memSubDomain.getJumpCondition(volRegionVar);
                    if (jc == null) {
                        jc = new JumpCondition(volRegionVar);
                        memSubDomain.addJumpCondition(jc);
                    }
                    Expression flux = getIdentifierSubstitutions(resolvedFluxes[i].getFluxExpression(), resolvedFluxes[i].getUnitDefinition(), membraneStructureAnalyzer.getSurfaceClass());
                    if (memSubDomain.getInsideCompartment().getName().equals(sm.getGeometryClass().getName())) {
                        jc.setInFlux(flux);
                    } else if (memSubDomain.getOutsideCompartment().getName().equals(sm.getGeometryClass().getName())) {
                        jc.setOutFlux(flux);
                    } else {
                        throw new RuntimeException("Application  " + simContext.getName() + " : " + scm.getSpeciesContext().getName() + " has spatially resolved flux at membrane " + scm.getSpeciesContext().getStructure().getName() + " with a non-local flux species " + scm.getSpeciesContext().getName());
                    }
                } else {
                    throw new MappingException("Application  " + simContext.getName() + " : " + scm.getSpeciesContext().getName() + " has spatially resolved flux at membrane " + scm.getSpeciesContext().getStructure().getName() + ", but doesn't diffuse in compartment " + scm.getSpeciesContext().getStructure().getName());
                }
            }
        }
        // 
        // create fast system (if neccessary)
        // 
        SpeciesContextMapping[] fastSpeciesContextMappings = membraneStructureAnalyzer.getFastSpeciesContextMappings();
        if (fastSpeciesContextMappings != null) {
            FastSystem fastSystem = new FastSystem(mathDesc);
            for (int i = 0; i < fastSpeciesContextMappings.length; i++) {
                SpeciesContextMapping scm = fastSpeciesContextMappings[i];
                if (scm.getFastInvariant() == null) {
                    // 
                    // independant-fast variable, create a fastRate object
                    // 
                    VCUnitDefinition rateUnit = scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit);
                    FastRate fastRate = new FastRate(getIdentifierSubstitutions(scm.getFastRate(), rateUnit, surfaceClass));
                    fastSystem.addFastRate(fastRate);
                } else {
                    // 
                    // dependant-fast variable, create a fastInvariant object
                    // 
                    VCUnitDefinition invariantUnit = scm.getSpeciesContext().getUnitDefinition();
                    FastInvariant fastInvariant = new FastInvariant(getIdentifierSubstitutions(scm.getFastInvariant(), invariantUnit, surfaceClass));
                    fastSystem.addFastInvariant(fastInvariant);
                }
            }
            memSubDomain.setFastSystem(fastSystem);
            // constructor calls the 'refresh' method which constructs depemdency matrix, dependent/independent vars and pseudoconstants, etc.
            // FastSystemAnalyzer fs_analyzer =
            new FastSystemAnalyzer(fastSystem, mathDesc);
        }
        // 
        // create Membrane-region equations for potential of this resolved membrane
        // 
        Structure[] resolvedSurfaceStructures = membraneStructureAnalyzer.getStructures();
        for (int m = 0; m < resolvedSurfaceStructures.length; m++) {
            if (resolvedSurfaceStructures[m] instanceof Membrane) {
                Membrane membrane = (Membrane) resolvedSurfaceStructures[m];
                MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membrane);
                if (membraneMapping.getCalculateVoltage()) {
                    ElectricalDevice[] membraneDevices = potentialMapping.getElectricalDevices(membrane);
                    int numCapacitiveDevices = 0;
                    MembraneElectricalDevice capacitiveDevice = null;
                    for (int i = 0; i < membraneDevices.length; i++) {
                        if (membraneDevices[i] instanceof MembraneElectricalDevice) {
                            numCapacitiveDevices++;
                            capacitiveDevice = (MembraneElectricalDevice) membraneDevices[i];
                        }
                    }
                    if (numCapacitiveDevices != 1) {
                        throw new MappingException("expecting 1 capacitive electrical device on graph edge for membrane " + membrane.getName() + ", found '" + numCapacitiveDevices + "'");
                    }
                    if (mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping.getGeometryClass())) instanceof MembraneRegionVariable) {
                        MembraneRegionVariable vVar = (MembraneRegionVariable) mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping.getGeometryClass()));
                        Parameter initialVoltageParm = capacitiveDevice.getMembraneMapping().getInitialVoltageParameter();
                        Expression initExp = getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), capacitiveDevice.getMembraneMapping().getGeometryClass());
                        MembraneRegionEquation vEquation = new MembraneRegionEquation(vVar, initExp);
                        vEquation.setMembraneRateExpression(getIdentifierSubstitutions(potentialMapping.getOdeRHS(capacitiveDevice, this), membrane.getMembraneVoltage().getUnitDefinition().divideBy(timeUnit), capacitiveDevice.getMembraneMapping().getGeometryClass()));
                        memSubDomain.addEquation(vEquation);
                    }
                }
            }
        }
    }
    // create equations for event assignment or rate rule targets that are model params/species, etc.
    Set<VolVariable> hashKeySet = eventVolVarHash.keySet();
    Iterator<VolVariable> volVarsIter = hashKeySet.iterator();
    // working under the assumption that we are dealing with non-spatial math, hence only one compartment domain!
    SubDomain subDomain = mathDesc.getSubDomains().nextElement();
    while (volVarsIter.hasNext()) {
        VolVariable volVar = volVarsIter.next();
        EventAssignmentOrRateRuleInitParameter initParam = eventVolVarHash.get(volVar);
        // check event initial condition, it shouldn't contain vars, we have to do it here, coz we want to substitute functions...etc.
        Expression eapExp = MathUtilities.substituteFunctions(initParam.getExpression(), mathDesc);
        if (eapExp.getSymbols() != null) {
            for (String symbol : eapExp.getSymbols()) {
                SymbolTableEntry ste = eapExp.getSymbolBinding(symbol);
                if (ste instanceof VolVariable || ste instanceof MemVariable) {
                    throw new MathException("Variables are not allowed in Event assignment initial condition.\nEvent assignment target: " + volVar.getName() + " has variable (" + symbol + ") in its expression.");
                }
            }
        }
        Expression rateExpr = new Expression(0.0);
        RateRuleRateParameter rateParam = rateRuleRateParamHash.get(volVar);
        if (rateParam != null) {
            // this is a rate rule, get its expression.
            rateExpr = new Expression(getMathSymbol(rateParam, null));
        }
        Equation equation = new OdeEquation(volVar, new Expression(getMathSymbol(initParam, null)), rateExpr);
        subDomain.addEquation(equation);
    }
    // events - add events to math desc for event assignments that have parameters as target variables
    if (bioevents != null && bioevents.length > 0) {
        for (BioEvent be : bioevents) {
            // transform the bioEvent trigger/delay to math Event
            LocalParameter genTriggerParam = be.getParameter(BioEventParameterType.GeneralTriggerFunction);
            Expression mathTriggerExpr = getIdentifierSubstitutions(new Expression(genTriggerParam, be.getNameScope()), modelUnitSystem.getInstance_DIMENSIONLESS(), null);
            Delay mathDelay = null;
            LocalParameter delayParam = be.getParameter(BioEventParameterType.TriggerDelay);
            if (delayParam != null && delayParam.getExpression() != null && !delayParam.getExpression().compareEqual(new Expression(0.0))) {
                boolean bUseValsFromTriggerTime = be.getUseValuesFromTriggerTime();
                Expression mathDelayExpr = getIdentifierSubstitutions(new Expression(delayParam, be.getNameScope()), timeUnit, null);
                mathDelay = new Delay(bUseValsFromTriggerTime, mathDelayExpr);
            }
            // now deal with (bio)event Assignment translation to math EventAssignment
            ArrayList<EventAssignment> eventAssignments = be.getEventAssignments();
            ArrayList<Event.EventAssignment> mathEventAssignmentsList = new ArrayList<Event.EventAssignment>();
            if (eventAssignments != null) {
                for (EventAssignment ea : eventAssignments) {
                    SymbolTableEntry ste = simContext.getEntry(ea.getTarget().getName());
                    if (ste instanceof StructureSize) {
                        throw new RuntimeException("Event Assignment Variable for compartment size is not supported yet");
                    }
                    VCUnitDefinition eventAssignVarUnit = ste.getUnitDefinition();
                    Variable variable = varHash.getVariable(ste.getName());
                    Event.EventAssignment mathEA = new Event.EventAssignment(variable, getIdentifierSubstitutions(ea.getAssignmentExpression(), eventAssignVarUnit, null));
                    mathEventAssignmentsList.add(mathEA);
                }
            }
            // use the translated trigger, delay and event assignments to create (math) event
            Event mathEvent = new Event(be.getName(), mathTriggerExpr, mathDelay, mathEventAssignmentsList);
            mathDesc.addEvent(mathEvent);
        }
    }
    if (simContext.getMicroscopeMeasurement() != null && simContext.getMicroscopeMeasurement().getFluorescentSpecies().size() > 0) {
        MicroscopeMeasurement measurement = simContext.getMicroscopeMeasurement();
        Expression volumeConcExp = new Expression(0.0);
        Expression membraneDensityExp = new Expression(0.0);
        for (SpeciesContext speciesContext : measurement.getFluorescentSpecies()) {
            GeometryClass geometryClass = simContext.getGeometryContext().getStructureMapping(speciesContext.getStructure()).getGeometryClass();
            StructureMapping structureMapping = simContext.getGeometryContext().getStructureMapping(speciesContext.getStructure());
            StructureMappingParameter unitSizeParameter = structureMapping.getUnitSizeParameter();
            Expression mappedSpeciesContextExpression = Expression.mult(unitSizeParameter.getExpression(), new Expression(getMathSymbol(speciesContext, geometryClass)));
            VCUnitDefinition mappedSpeciesContextUnit = unitSizeParameter.getUnitDefinition().multiplyBy(speciesContext.getUnitDefinition());
            if (geometryClass instanceof SubVolume) {
                // volume function
                int dimension = 3;
                VCUnitDefinition desiredConcUnits = model.getUnitSystem().getInstance("molecules").divideBy(model.getUnitSystem().getLengthUnit().raiseTo(new ucar.units_vcell.RationalNumber(dimension)));
                Expression unitFactor = getUnitFactor(desiredConcUnits.divideBy(mappedSpeciesContextUnit));
                volumeConcExp = Expression.add(volumeConcExp, Expression.mult(unitFactor, mappedSpeciesContextExpression)).flatten();
            } else if (geometryClass instanceof SurfaceClass) {
                // membrane function
                int dimension = 2;
                VCUnitDefinition desiredSurfaceDensityUnits = model.getUnitSystem().getInstance("molecules").divideBy(model.getUnitSystem().getLengthUnit().raiseTo(new ucar.units_vcell.RationalNumber(dimension)));
                Expression unitFactor = getUnitFactor(desiredSurfaceDensityUnits.divideBy(mappedSpeciesContextUnit));
                membraneDensityExp = Expression.add(membraneDensityExp, Expression.mult(unitFactor, mappedSpeciesContextExpression)).flatten();
            } else {
                throw new MathException("unsupported geometry mapping for microscopy measurement");
            }
        }
        ConvolutionKernel kernel = measurement.getConvolutionKernel();
        if (kernel instanceof ExperimentalPSF) {
            if (!membraneDensityExp.isZero()) {
                throw new MappingException("membrane variables and functions not yet supported for Z projection in Microcopy Measurements");
            }
            ExperimentalPSF psf = (ExperimentalPSF) kernel;
            DataSymbol psfDataSymbol = psf.getPSFDataSymbol();
            if (psfDataSymbol instanceof FieldDataSymbol) {
                FieldDataSymbol fieldDataSymbol = (FieldDataSymbol) psfDataSymbol;
                String fieldDataName = ((FieldDataSymbol) psfDataSymbol).getExternalDataIdentifier().getName();
                Expression psfExp = Expression.function(FieldFunctionDefinition.FUNCTION_name, new Expression("'" + fieldDataName + "'"), new Expression("'" + fieldDataSymbol.getFieldDataVarName() + "'"), new Expression(fieldDataSymbol.getFieldDataVarTime()), new Expression("'" + fieldDataSymbol.getFieldDataVarType() + "'"));
                varHash.addVariable(new Function("__PSF__", psfExp, null));
            }
            Expression convExp = Expression.function(ConvFunctionDefinition.FUNCTION_name, volumeConcExp, new Expression("__PSF__"));
            varHash.addVariable(newFunctionOrConstant(measurement.getName(), convExp, null));
        } else if (kernel instanceof GaussianConvolutionKernel) {
            GaussianConvolutionKernel gaussianConvolutionKernel = (GaussianConvolutionKernel) kernel;
            GaussianConvolutionDataGeneratorKernel mathKernel = new GaussianConvolutionDataGeneratorKernel(gaussianConvolutionKernel.getSigmaXY_um(), gaussianConvolutionKernel.getSigmaZ_um());
            ConvolutionDataGenerator dataGenerator = new ConvolutionDataGenerator(measurement.getName(), mathKernel, volumeConcExp, membraneDensityExp);
            mathDesc.getPostProcessingBlock().addDataGenerator(dataGenerator);
        } else if (kernel instanceof ProjectionZKernel) {
            if (mathDesc.getGeometry().getDimension() == 3) {
                if (!membraneDensityExp.isZero()) {
                    throw new MappingException("membrane variables and functions not yet supported for Z projection in Microcopy Measurements");
                }
                ProjectionDataGenerator dataGenerator = new ProjectionDataGenerator(measurement.getName(), null, ProjectionDataGenerator.Axis.z, ProjectionDataGenerator.Operation.sum, volumeConcExp);
                mathDesc.getPostProcessingBlock().addDataGenerator(dataGenerator);
            } else {
                throw new MappingException("Z Projection is only supported in 3D spatial applications.");
            }
        }
    }
    // 
    for (int i = 0; i < fieldMathMappingParameters.length; i++) {
        if (fieldMathMappingParameters[i] instanceof UnitFactorParameter) {
            GeometryClass geometryClass = fieldMathMappingParameters[i].getGeometryClass();
            Variable variable = newFunctionOrConstant(getMathSymbol(fieldMathMappingParameters[i], geometryClass), getIdentifierSubstitutions(fieldMathMappingParameters[i].getExpression(), fieldMathMappingParameters[i].getUnitDefinition(), geometryClass), fieldMathMappingParameters[i].getGeometryClass());
            if (mathDesc.getVariable(variable.getName()) == null) {
                mathDesc.addVariable(variable);
            }
        }
    }
    if (!mathDesc.isValid()) {
        System.out.println(mathDesc.getVCML_database());
        throw new MappingException("generated an invalid mathDescription: " + mathDesc.getWarning());
    }
// System.out.println("]]]]]]]]]]]]]]]]]]]]]] VCML string begin ]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]");
// System.out.println(mathDesc.getVCML());
// System.out.println("]]]]]]]]]]]]]]]]]]]]]] VCML string end ]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]");
}
Also used : MembraneSubDomain(cbit.vcell.math.MembraneSubDomain) ArrayList(java.util.ArrayList) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) SpeciesContext(cbit.vcell.model.SpeciesContext) Feature(cbit.vcell.model.Feature) MemVariable(cbit.vcell.math.MemVariable) SubVolume(cbit.vcell.geometry.SubVolume) Vector(java.util.Vector) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) FastInvariant(cbit.vcell.math.FastInvariant) GaussianConvolutionKernel(cbit.vcell.mapping.MicroscopeMeasurement.GaussianConvolutionKernel) PropertyVetoException(java.beans.PropertyVetoException) FieldDataSymbol(cbit.vcell.data.FieldDataSymbol) DataSymbol(cbit.vcell.data.DataSymbol) VCUnitDefinition(cbit.vcell.units.VCUnitDefinition) FastSystem(cbit.vcell.math.FastSystem) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) ReactionStep(cbit.vcell.model.ReactionStep) Map(java.util.Map) HashMap(java.util.HashMap) MembraneRegionEquation(cbit.vcell.math.MembraneRegionEquation) SurfaceClass(cbit.vcell.geometry.SurfaceClass) VariableHash(cbit.vcell.math.VariableHash) ExperimentalPSF(cbit.vcell.mapping.MicroscopeMeasurement.ExperimentalPSF) ConvolutionDataGenerator(cbit.vcell.math.ConvolutionDataGenerator) GaussianConvolutionDataGeneratorKernel(cbit.vcell.math.ConvolutionDataGenerator.GaussianConvolutionDataGeneratorKernel) Structure(cbit.vcell.model.Structure) ModelUnitSystem(cbit.vcell.model.ModelUnitSystem) LocalParameter(cbit.vcell.mapping.ParameterContext.LocalParameter) VoltageClampElectricalDevice(cbit.vcell.mapping.potential.VoltageClampElectricalDevice) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) Expression(cbit.vcell.parser.Expression) Model(cbit.vcell.model.Model) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) Parameter(cbit.vcell.model.Parameter) SpeciesContextSpecProxyParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecProxyParameter) SimulationContextParameter(cbit.vcell.mapping.SimulationContext.SimulationContextParameter) ModelParameter(cbit.vcell.model.Model.ModelParameter) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) LocalParameter(cbit.vcell.mapping.ParameterContext.LocalParameter) Event(cbit.vcell.math.Event) ProjectionDataGenerator(cbit.vcell.math.ProjectionDataGenerator) SurfaceRegionObject(cbit.vcell.mapping.spatial.SurfaceRegionObject) FieldDataSymbol(cbit.vcell.data.FieldDataSymbol) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) HashMap(java.util.HashMap) MathDescription(cbit.vcell.math.MathDescription) MembraneElectricalDevice(cbit.vcell.mapping.potential.MembraneElectricalDevice) Delay(cbit.vcell.math.Event.Delay) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) SubDomain(cbit.vcell.math.SubDomain) PointSubDomain(cbit.vcell.math.PointSubDomain) MembraneSubDomain(cbit.vcell.math.MembraneSubDomain) PropertyVetoException(java.beans.PropertyVetoException) PdeEquation(cbit.vcell.math.PdeEquation) CurrentClampElectricalDevice(cbit.vcell.mapping.potential.CurrentClampElectricalDevice) SpatialQuantity(cbit.vcell.mapping.spatial.SpatialObject.SpatialQuantity) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) EventAssignment(cbit.vcell.mapping.BioEvent.EventAssignment) CurrentClampElectricalDevice(cbit.vcell.mapping.potential.CurrentClampElectricalDevice) MembraneElectricalDevice(cbit.vcell.mapping.potential.MembraneElectricalDevice) ElectricalDevice(cbit.vcell.mapping.potential.ElectricalDevice) VoltageClampElectricalDevice(cbit.vcell.mapping.potential.VoltageClampElectricalDevice) VolVariable(cbit.vcell.math.VolVariable) StructureSize(cbit.vcell.model.Structure.StructureSize) ProjectionZKernel(cbit.vcell.mapping.MicroscopeMeasurement.ProjectionZKernel) ModelParameter(cbit.vcell.model.Model.ModelParameter) OdeEquation(cbit.vcell.math.OdeEquation) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) SubDomain(cbit.vcell.math.SubDomain) PointSubDomain(cbit.vcell.math.PointSubDomain) Domain(cbit.vcell.math.Variable.Domain) MembraneSubDomain(cbit.vcell.math.MembraneSubDomain) JumpCondition(cbit.vcell.math.JumpCondition) GeometryClass(cbit.vcell.geometry.GeometryClass) VolVariable(cbit.vcell.math.VolVariable) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) PointVariable(cbit.vcell.math.PointVariable) VolumeRegionVariable(cbit.vcell.math.VolumeRegionVariable) MemVariable(cbit.vcell.math.MemVariable) Variable(cbit.vcell.math.Variable) SpeciesContextSpecProxyParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecProxyParameter) Constant(cbit.vcell.math.Constant) VolumeRegionVariable(cbit.vcell.math.VolumeRegionVariable) Function(cbit.vcell.math.Function) SymbolTableEntry(cbit.vcell.parser.SymbolTableEntry) Membrane(cbit.vcell.model.Membrane) VolumeRegionEquation(cbit.vcell.math.VolumeRegionEquation) PotentialMapping(cbit.vcell.mapping.potential.PotentialMapping) EventAssignment(cbit.vcell.mapping.BioEvent.EventAssignment) FieldFunctionArguments(cbit.vcell.field.FieldFunctionArguments) PdeEquation(cbit.vcell.math.PdeEquation) ComputeMembraneMetricEquation(cbit.vcell.math.ComputeMembraneMetricEquation) VolumeRegionEquation(cbit.vcell.math.VolumeRegionEquation) OdeEquation(cbit.vcell.math.OdeEquation) MembraneRegionEquation(cbit.vcell.math.MembraneRegionEquation) Equation(cbit.vcell.math.Equation) FastRate(cbit.vcell.math.FastRate) SimulationContextParameter(cbit.vcell.mapping.SimulationContext.SimulationContextParameter) ConvolutionKernel(cbit.vcell.mapping.MicroscopeMeasurement.ConvolutionKernel) GaussianConvolutionKernel(cbit.vcell.mapping.MicroscopeMeasurement.GaussianConvolutionKernel) MathException(cbit.vcell.math.MathException)

Example 3 with MembraneRegionVariable

use of cbit.vcell.math.MembraneRegionVariable in project vcell by virtualcell.

the class DiffEquMathMapping method refreshVariables.

/**
 * This method was created in VisualAge.
 */
private void refreshVariables() throws MappingException {
    // System.out.println("MathMapping.refreshVariables()");
    // 
    // non-constant dependent variables require a function
    // 
    Enumeration<SpeciesContextMapping> enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = enum1.nextElement();
        SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(scm.getSpeciesContext());
        if (scm.getDependencyExpression() != null && !scs.isConstant()) {
            // scm.setVariable(new Function(scm.getSpeciesContext().getName(),scm.getDependencyExpression()));
            scm.setVariable(null);
        }
        if (getSimulationContext().hasEventAssignment(scs.getSpeciesContext())) {
            scm.setDependencyExpression(null);
        }
    }
    // 
    // non-constant independent variables require either a membrane or volume variable
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(scm.getSpeciesContext());
        Expression depExp = scm.getDependencyExpression();
        boolean isVariable = !scs.isConstant();
        boolean hasEvent = getSimulationContext().hasEventAssignment(scs.getSpeciesContext());
        if (depExp == null && (isVariable || hasEvent)) {
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(scm.getSpeciesContext().getStructure());
            Structure struct = scm.getSpeciesContext().getStructure();
            Domain domain = null;
            if (sm.getGeometryClass() != null) {
                domain = new Domain(sm.getGeometryClass());
            }
            if (struct instanceof Feature || struct instanceof Membrane) {
                if (sm.getGeometryClass() instanceof SurfaceClass) {
                    if (scs.isWellMixed()) {
                        scm.setVariable(new MembraneRegionVariable(scm.getSpeciesContext().getName(), domain));
                    } else if (getSimulationContext().isStoch() && getSimulationContext().getGeometry().getDimension() > 0 && !scs.isForceContinuous()) {
                        scm.setVariable(new MemVariable(scm.getSpeciesContext().getName() + "_conc", domain));
                    } else {
                        scm.setVariable(new MemVariable(scm.getSpeciesContext().getName(), domain));
                    }
                } else {
                    if (scs.isWellMixed()) {
                        scm.setVariable(new VolumeRegionVariable(scm.getSpeciesContext().getName(), domain));
                    } else if (getSimulationContext().isStoch() && getSimulationContext().getGeometry().getDimension() > 0 && !scs.isForceContinuous()) {
                        scm.setVariable(new VolVariable(scm.getSpeciesContext().getName() + "_conc", domain));
                    } else {
                        scm.setVariable(new VolVariable(scm.getSpeciesContext().getName(), domain));
                    }
                }
            } else {
                throw new MappingException("class " + scm.getSpeciesContext().getStructure().getClass() + " not supported");
            }
            mathSymbolMapping.put(scm.getSpeciesContext(), scm.getVariable().getName());
        }
    }
}
Also used : MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) SurfaceClass(cbit.vcell.geometry.SurfaceClass) VolVariable(cbit.vcell.math.VolVariable) Feature(cbit.vcell.model.Feature) VolumeRegionVariable(cbit.vcell.math.VolumeRegionVariable) MemVariable(cbit.vcell.math.MemVariable) Expression(cbit.vcell.parser.Expression) Membrane(cbit.vcell.model.Membrane) Structure(cbit.vcell.model.Structure) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) SubDomain(cbit.vcell.math.SubDomain) PointSubDomain(cbit.vcell.math.PointSubDomain) Domain(cbit.vcell.math.Variable.Domain) MembraneSubDomain(cbit.vcell.math.MembraneSubDomain)

Example 4 with MembraneRegionVariable

use of cbit.vcell.math.MembraneRegionVariable in project vcell by virtualcell.

the class XmlReader method getMembraneRegionEquation.

/**
 * This method returns a MembraneRegionEquation from a XML Element.
 * Creation date: (5/17/2001 3:52:40 PM)
 * @return cbit.vcell.math.MembraneRegionEquation
 * @param param org.jdom.Element
 * @exception cbit.vcell.xml.XmlParseException The exception description.
 */
private MembraneRegionEquation getMembraneRegionEquation(Element param, MathDescription mathDesc) throws XmlParseException {
    // get attributes
    String varname = unMangle(param.getAttributeValue(XMLTags.NameAttrTag));
    // find reference in the dictionnary
    // try a MembraneRegionVariable
    MembraneRegionVariable varref = (MembraneRegionVariable) mathDesc.getVariable(varname);
    if (varref == null) {
        throw new XmlParseException("The reference to the MembraneRegion variable " + varname + " could not be resolved!");
    }
    // get Initial condition
    String temp = param.getChildText(XMLTags.InitialTag, vcNamespace);
    Expression exp;
    exp = unMangleExpression(temp);
    // ** Create the Equation **
    MembraneRegionEquation memRegEq = new MembraneRegionEquation(varref, exp);
    // set the Uniform Rate
    temp = param.getChildText(XMLTags.UniformRateTag, vcNamespace);
    exp = unMangleExpression(temp);
    memRegEq.setUniformRateExpression(exp);
    // set the Membrane Rate
    temp = param.getChildText(XMLTags.MembraneRateTag, vcNamespace);
    exp = unMangleExpression(temp);
    memRegEq.setMembraneRateExpression(exp);
    return memRegEq;
}
Also used : MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) Expression(cbit.vcell.parser.Expression) MembraneRegionEquation(cbit.vcell.math.MembraneRegionEquation)

Example 5 with MembraneRegionVariable

use of cbit.vcell.math.MembraneRegionVariable in project vcell by virtualcell.

the class MathMapping_4_8 method refreshMathDescription.

/**
 * This method was created in VisualAge.
 */
private void refreshMathDescription() throws MappingException, MatrixException, MathException, ExpressionException, ModelException {
    // All sizes must be set for new ODE models and ratios must be set for old ones.
    simContext.checkValidity();
    // 
    // temporarily place all variables in a hashtable (before binding) and discarding duplicates (check for equality)
    // 
    VariableHash varHash = new VariableHash();
    StructureMapping[] structureMappings = simContext.getGeometryContext().getStructureMappings();
    Model model = simContext.getModel();
    StructureTopology structTopology = model.getStructureTopology();
    // 
    // verify that all structures are mapped to subvolumes and all subvolumes are mapped to a structure
    // 
    Structure[] structures = simContext.getGeometryContext().getModel().getStructures();
    for (int i = 0; i < structures.length; i++) {
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(structures[i]);
        if (sm == null || (sm instanceof FeatureMapping && getSubVolume((FeatureMapping) sm) == null)) {
            throw new MappingException("model structure '" + structures[i].getName() + "' not mapped to a geometry subdomain");
        }
        if (sm != null && (sm instanceof MembraneMapping) && ((MembraneMapping) sm).getVolumeFractionParameter() != null) {
            Expression volFractExp = ((MembraneMapping) sm).getVolumeFractionParameter().getExpression();
            if (volFractExp != null) {
                try {
                    double volFract = volFractExp.evaluateConstant();
                    if (volFract >= 1.0) {
                        throw new MappingException("model structure '" + structTopology.getInsideFeature(((MembraneMapping) sm).getMembrane()).getName() + "' has volume fraction >= 1.0");
                    }
                } catch (ExpressionException e) {
                }
            }
        }
    }
    SubVolume[] subVolumes = simContext.getGeometryContext().getGeometry().getGeometrySpec().getSubVolumes();
    for (int i = 0; i < subVolumes.length; i++) {
        if (getStructures(subVolumes[i]) == null || getStructures(subVolumes[i]).length == 0) {
            throw new MappingException("geometry subdomain '" + subVolumes[i].getName() + "' not mapped from a model structure");
        }
    }
    // deals with model parameters
    Hashtable<VolVariable, EventAssignmentInitParameter> eventVolVarHash = new Hashtable<VolVariable, EventAssignmentInitParameter>();
    ModelParameter[] modelParameters = model.getModelParameters();
    if (simContext.getGeometry().getDimension() == 0) {
        // 
        // global parameters from model (that presently are constants)
        // 
        BioEvent[] bioEvents = simContext.getBioEvents();
        ArrayList<SymbolTableEntry> eventAssignTargets = new ArrayList<SymbolTableEntry>();
        if (bioEvents != null && bioEvents.length > 0) {
            for (BioEvent be : bioEvents) {
                for (EventAssignment ea : be.getEventAssignments()) {
                    if (!eventAssignTargets.contains(ea.getTarget())) {
                        eventAssignTargets.add(ea.getTarget());
                    }
                }
            }
        }
        for (int j = 0; j < modelParameters.length; j++) {
            Expression modelParamExpr = getIdentifierSubstitutions(modelParameters[j].getExpression(), modelParameters[j].getUnitDefinition(), null);
            if (eventAssignTargets.contains(modelParameters[j])) {
                EventAssignmentInitParameter eap = null;
                try {
                    eap = addEventAssignmentInitParameter(modelParameters[j].getName(), modelParameters[j].getExpression(), PARAMETER_ROLE_EVENTASSIGN_INITCONDN, modelParameters[j].getUnitDefinition());
                } catch (PropertyVetoException e) {
                    e.printStackTrace(System.out);
                    throw new MappingException(e.getMessage());
                }
                // varHash.addVariable(newFunctionOrConstant(getMathSymbol(eap, null), modelParamExpr));
                VolVariable volVar = new VolVariable(modelParameters[j].getName(), nullDomain);
                varHash.addVariable(volVar);
                eventVolVarHash.put(volVar, eap);
            } else {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(modelParameters[j], null), modelParamExpr));
            }
        }
    } else {
        // 
        for (int pass = 0; pass < 2; pass++) {
            for (int j = 0; j < modelParameters.length; j++) {
                Hashtable<String, Expression> structMappingVariantsHash = new Hashtable<String, Expression>();
                for (int k = 0; k < structureMappings.length; k++) {
                    String paramVariantName = null;
                    Expression paramVariantExpr = null;
                    if (modelParameters[j].getExpression().getSymbols() == null) {
                        paramVariantName = modelParameters[j].getName();
                        paramVariantExpr = getIdentifierSubstitutions(modelParameters[j].getExpression(), modelParameters[j].getUnitDefinition(), null);
                    } else {
                        paramVariantName = modelParameters[j].getName() + "_" + TokenMangler.fixTokenStrict(structureMappings[k].getStructure().getName());
                        // if the expression has symbols that do not belong in that structureMapping, do not create the variant.
                        Expression exp1 = modelParameters[j].getExpression();
                        Expression flattenedModelParamExpr = substituteGlobalParameters(exp1);
                        String[] symbols = flattenedModelParamExpr.getSymbols();
                        boolean bValid = true;
                        Structure sm_struct = structureMappings[k].getStructure();
                        if (symbols != null) {
                            for (int ii = 0; ii < symbols.length; ii++) {
                                SpeciesContext sc = model.getSpeciesContext(symbols[ii]);
                                if (sc != null) {
                                    // symbol[ii] is a speciesContext, check its structure with structureMapping[k].structure. If they are the same or
                                    // if it is the adjacent membrane(s), allow variant expression to be created. Else, continue.
                                    Structure sp_struct = sc.getStructure();
                                    if (sp_struct.compareEqual(sm_struct)) {
                                        bValid = bValid && true;
                                    } else {
                                        // if the 2 structures are not the same, are they adjacent? then 'bValid' is true, else false.
                                        if ((sm_struct instanceof Feature) && (sp_struct instanceof Membrane)) {
                                            Feature sm_feature = (Feature) sm_struct;
                                            Membrane sp_mem = (Membrane) sp_struct;
                                            if (sp_mem.compareEqual(structTopology.getParentStructure(sm_feature)) || (structTopology.getInsideFeature(sp_mem).compareEqual(sm_feature) || structTopology.getOutsideFeature(sp_mem).compareEqual(sm_feature))) {
                                                bValid = bValid && true;
                                            } else {
                                                bValid = bValid && false;
                                                break;
                                            }
                                        } else if ((sm_struct instanceof Membrane) && (sp_struct instanceof Feature)) {
                                            Feature sp_feature = (Feature) sp_struct;
                                            Membrane sm_mem = (Membrane) sm_struct;
                                            if (sm_mem.compareEqual(structTopology.getParentStructure(sp_feature)) || (structTopology.getInsideFeature(sm_mem).compareEqual(sp_feature) || structTopology.getOutsideFeature(sm_mem).compareEqual(sp_feature))) {
                                                bValid = bValid && true;
                                            } else {
                                                bValid = bValid && false;
                                                break;
                                            }
                                        } else {
                                            bValid = bValid && false;
                                            break;
                                        }
                                    }
                                }
                            }
                        }
                        if (bValid) {
                            if (pass == 0) {
                                paramVariantExpr = new Expression("VCELL_TEMPORARY_EXPRESSION_PLACEHOLDER");
                            } else {
                                paramVariantExpr = getIdentifierSubstitutions(modelParameters[j].getExpression(), modelParameters[j].getUnitDefinition(), structureMappings[k]);
                            }
                        }
                    }
                    if (paramVariantExpr != null) {
                        structMappingVariantsHash.put(paramVariantName, paramVariantExpr);
                    }
                }
                globalParamVariantsHash.put(modelParameters[j], structMappingVariantsHash);
            }
        }
        // 
        for (int j = 0; j < modelParameters.length; j++) {
            if (modelParameters[j].getExpression().getSymbols() == null) {
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(modelParameters[j], null), getIdentifierSubstitutions(modelParameters[j].getExpression(), modelParameters[j].getUnitDefinition(), null)));
            } else {
                Hashtable<String, Expression> smVariantsHash = globalParamVariantsHash.get(modelParameters[j]);
                for (int k = 0; k < structureMappings.length; k++) {
                    String variantName = modelParameters[j].getName() + "_" + TokenMangler.fixTokenStrict(structureMappings[k].getStructure().getName());
                    Expression variantExpr = smVariantsHash.get(variantName);
                    if (variantExpr != null) {
                        varHash.addVariable(newFunctionOrConstant(variantName, variantExpr));
                    }
                }
            }
        }
    }
    // 
    // gather only those reactionSteps that are not "excluded"
    // 
    ReactionSpec[] reactionSpecs = simContext.getReactionContext().getReactionSpecs();
    Vector<ReactionStep> rsList = new Vector<ReactionStep>();
    for (int i = 0; i < reactionSpecs.length; i++) {
        if (reactionSpecs[i].isExcluded() == false) {
            rsList.add(reactionSpecs[i].getReactionStep());
        }
    }
    ReactionStep[] reactionSteps = new ReactionStep[rsList.size()];
    rsList.copyInto(reactionSteps);
    // 
    for (int i = 0; i < reactionSteps.length; i++) {
        Kinetics.UnresolvedParameter[] unresolvedParameters = reactionSteps[i].getKinetics().getUnresolvedParameters();
        if (unresolvedParameters != null && unresolvedParameters.length > 0) {
            StringBuffer buffer = new StringBuffer();
            for (int j = 0; j < unresolvedParameters.length; j++) {
                if (j > 0) {
                    buffer.append(", ");
                }
                buffer.append(unresolvedParameters[j].getName());
            }
            throw new MappingException(reactionSteps[i].getDisplayType() + " '" + reactionSteps[i].getName() + "' contains unresolved identifier(s): " + buffer);
        }
    }
    // 
    // create new MathDescription (based on simContext's previous MathDescription if possible)
    // 
    MathDescription oldMathDesc = simContext.getMathDescription();
    mathDesc = null;
    if (oldMathDesc != null) {
        if (oldMathDesc.getVersion() != null) {
            mathDesc = new MathDescription(oldMathDesc.getVersion());
        } else {
            mathDesc = new MathDescription(oldMathDesc.getName());
        }
    } else {
        mathDesc = new MathDescription(simContext.getName() + "_generated");
    }
    // 
    // volume variables
    // 
    Enumeration<SpeciesContextMapping> enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = enum1.nextElement();
        if (scm.getVariable() instanceof VolVariable) {
            if (!(mathDesc.getVariable(scm.getVariable().getName()) instanceof VolVariable)) {
                varHash.addVariable(scm.getVariable());
            }
        }
    }
    // 
    // membrane variables
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof MemVariable) {
            varHash.addVariable(scm.getVariable());
        }
    }
    varHash.addVariable(new Constant(getMathSymbol(model.getFARADAY_CONSTANT(), null), getIdentifierSubstitutions(model.getFARADAY_CONSTANT().getExpression(), model.getFARADAY_CONSTANT().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getFARADAY_CONSTANT_NMOLE(), null), getIdentifierSubstitutions(model.getFARADAY_CONSTANT_NMOLE().getExpression(), model.getFARADAY_CONSTANT_NMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getGAS_CONSTANT(), null), getIdentifierSubstitutions(model.getGAS_CONSTANT().getExpression(), model.getGAS_CONSTANT().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(getMathSymbol(model.getTEMPERATURE(), null), getIdentifierSubstitutions(new Expression(simContext.getTemperatureKelvin()), model.getTEMPERATURE().getUnitDefinition(), null)));
    // 
    // only calculate potential if at least one MembraneMapping has CalculateVoltage == true
    // 
    boolean bCalculatePotential = false;
    for (int i = 0; i < structureMappings.length; i++) {
        if (structureMappings[i] instanceof MembraneMapping) {
            if (((MembraneMapping) structureMappings[i]).getCalculateVoltage()) {
                bCalculatePotential = true;
            }
        }
    }
    // (simContext.getGeometry().getDimension() == 0);
    potentialMapping = new PotentialMapping(simContext, this);
    potentialMapping.computeMath();
    if (bCalculatePotential) {
        // 
        // copy functions for currents and constants for capacitances
        // 
        ElectricalDevice[] devices = potentialMapping.getElectricalDevices();
        for (int j = 0; j < devices.length; j++) {
            if (devices[j] instanceof MembraneElectricalDevice) {
                MembraneElectricalDevice membraneElectricalDevice = (MembraneElectricalDevice) devices[j];
                MembraneMapping memMapping = membraneElectricalDevice.getMembraneMapping();
                Parameter specificCapacitanceParm = memMapping.getParameterFromRole(MembraneMapping.ROLE_SpecificCapacitance);
                varHash.addVariable(new Constant(getMathSymbol(specificCapacitanceParm, memMapping), getIdentifierSubstitutions(specificCapacitanceParm.getExpression(), specificCapacitanceParm.getUnitDefinition(), memMapping)));
                ElectricalDevice.ElectricalDeviceParameter transmembraneCurrentParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_TransmembraneCurrent);
                ElectricalDevice.ElectricalDeviceParameter totalCurrentParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_TotalCurrent);
                ElectricalDevice.ElectricalDeviceParameter capacitanceParm = membraneElectricalDevice.getParameterFromRole(ElectricalDevice.ROLE_Capacitance);
                if (totalCurrentParm != null && /* totalCurrentDensityParm.getExpression()!=null && */
                memMapping.getCalculateVoltage()) {
                    Expression totalCurrentDensityExp = (totalCurrentParm.getExpression() != null) ? (totalCurrentParm.getExpression()) : (new Expression(0.0));
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, membraneElectricalDevice.getMembraneMapping()), getIdentifierSubstitutions(totalCurrentDensityExp, totalCurrentParm.getUnitDefinition(), membraneElectricalDevice.getMembraneMapping())));
                }
                if (transmembraneCurrentParm != null && transmembraneCurrentParm.getExpression() != null && memMapping.getCalculateVoltage()) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(transmembraneCurrentParm, membraneElectricalDevice.getMembraneMapping()), getIdentifierSubstitutions(transmembraneCurrentParm.getExpression(), transmembraneCurrentParm.getUnitDefinition(), membraneElectricalDevice.getMembraneMapping())));
                }
                if (capacitanceParm != null && capacitanceParm.getExpression() != null && memMapping.getCalculateVoltage()) {
                    StructureMappingParameter sizeParameter = membraneElectricalDevice.getMembraneMapping().getSizeParameter();
                    if (simContext.getGeometry().getDimension() == 0 && (sizeParameter.getExpression() == null || sizeParameter.getExpression().isZero())) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(capacitanceParm, membraneElectricalDevice.getMembraneMapping()), getIdentifierSubstitutions(Expression.mult(memMapping.getNullSizeParameterValue(), specificCapacitanceParm.getExpression()), capacitanceParm.getUnitDefinition(), membraneElectricalDevice.getMembraneMapping())));
                    } else {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(capacitanceParm, membraneElectricalDevice.getMembraneMapping()), getIdentifierSubstitutions(capacitanceParm.getExpression(), capacitanceParm.getUnitDefinition(), membraneElectricalDevice.getMembraneMapping())));
                    }
                }
                // 
                if (membraneElectricalDevice.getDependentVoltageExpression() == null) {
                    // is Voltage Independent?
                    StructureMapping.StructureMappingParameter initialVoltageParm = memMapping.getInitialVoltageParameter();
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(initialVoltageParm, memMapping), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), memMapping)));
                } else // 
                // membrane forced potential
                // 
                {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(memMapping.getMembrane().getMembraneVoltage(), memMapping), getIdentifierSubstitutions(membraneElectricalDevice.getDependentVoltageExpression(), memMapping.getMembrane().getMembraneVoltage().getUnitDefinition(), memMapping)));
                }
            } else if (devices[j] instanceof CurrentClampElectricalDevice) {
                CurrentClampElectricalDevice currentClampDevice = (CurrentClampElectricalDevice) devices[j];
                // total current = current source (no capacitance)
                Parameter totalCurrentParm = currentClampDevice.getParameterFromRole(CurrentClampElectricalDevice.ROLE_TotalCurrent);
                Parameter currentParm = currentClampDevice.getParameterFromRole(CurrentClampElectricalDevice.ROLE_TransmembraneCurrent);
                // Parameter dependentVoltage = currentClampDevice.getCurrentClampStimulus().getVoltageParameter();
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, null), getIdentifierSubstitutions(totalCurrentParm.getExpression(), totalCurrentParm.getUnitDefinition(), null)));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(currentParm, null), getIdentifierSubstitutions(currentParm.getExpression(), currentParm.getUnitDefinition(), null)));
                // varHash.addVariable(newFunctionOrConstant(getMathSymbol(dependentVoltage,null),getIdentifierSubstitutions(currentClampDevice.getDependentVoltageExpression(),dependentVoltage.getUnitDefinition(),null)));
                // 
                // add user-defined parameters
                // 
                ElectricalDevice.ElectricalDeviceParameter[] parameters = currentClampDevice.getParameters();
                for (int k = 0; k < parameters.length; k++) {
                    if (parameters[k].getExpression() != null) {
                        // guards against voltage parameters that are "variable".
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(parameters[k], null), getIdentifierSubstitutions(parameters[k].getExpression(), parameters[k].getUnitDefinition(), null)));
                    }
                }
            } else if (devices[j] instanceof VoltageClampElectricalDevice) {
                VoltageClampElectricalDevice voltageClampDevice = (VoltageClampElectricalDevice) devices[j];
                // total current = current source (no capacitance)
                Parameter totalCurrent = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_TotalCurrent);
                Parameter totalCurrentParm = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_TotalCurrent);
                Parameter voltageParm = voltageClampDevice.getParameterFromRole(VoltageClampElectricalDevice.ROLE_Voltage);
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrent, null), getIdentifierSubstitutions(totalCurrent.getExpression(), totalCurrent.getUnitDefinition(), null)));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(totalCurrentParm, null), getIdentifierSubstitutions(totalCurrentParm.getExpression(), totalCurrentParm.getUnitDefinition(), null)));
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(voltageParm, null), getIdentifierSubstitutions(voltageParm.getExpression(), voltageParm.getUnitDefinition(), null)));
                // 
                // add user-defined parameters
                // 
                ElectricalDevice.ElectricalDeviceParameter[] parameters = voltageClampDevice.getParameters();
                for (int k = 0; k < parameters.length; k++) {
                    if (parameters[k].getRole() == ElectricalDevice.ROLE_UserDefined) {
                        varHash.addVariable(newFunctionOrConstant(getMathSymbol(parameters[k], null), getIdentifierSubstitutions(parameters[k].getExpression(), parameters[k].getUnitDefinition(), null)));
                    }
                }
            }
        }
    } else {
        // 
        for (int j = 0; j < structureMappings.length; j++) {
            if (structureMappings[j] instanceof MembraneMapping) {
                MembraneMapping memMapping = (MembraneMapping) structureMappings[j];
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(memMapping.getMembrane().getMembraneVoltage(), memMapping), getIdentifierSubstitutions(memMapping.getInitialVoltageParameter().getExpression(), memMapping.getInitialVoltageParameter().getUnitDefinition(), memMapping)));
            }
        }
    }
    // 
    for (int j = 0; j < structureMappings.length; j++) {
        if (structureMappings[j] instanceof MembraneMapping) {
            MembraneMapping membraneMapping = (MembraneMapping) structureMappings[j];
            Membrane.MembraneVoltage membraneVoltage = membraneMapping.getMembrane().getMembraneVoltage();
            ElectricalDevice[] membraneDevices = potentialMapping.getElectricalDevices(membraneMapping.getMembrane());
            // ElectricalDevice membraneDevice = null;
            for (int i = 0; i < membraneDevices.length; i++) {
                if (membraneDevices[i].hasCapacitance() && membraneDevices[i].getDependentVoltageExpression() == null) {
                    if (membraneMapping.getCalculateVoltage() && bCalculatePotential) {
                        if (getResolved(membraneMapping)) {
                            // 
                            if (mathDesc.getVariable(Membrane.MEMBRANE_VOLTAGE_REGION_NAME) == null) {
                                // varHash.addVariable(new MembraneRegionVariable(MembraneVoltage.MEMBRANE_VOLTAGE_REGION_NAME));
                                varHash.addVariable(new MembraneRegionVariable(getMathSymbol(membraneVoltage, membraneMapping), nullDomain));
                            }
                        } else {
                            // 
                            // spatially unresolved membrane, and must solve for potential ... make VolVariable for this compartment
                            // 
                            varHash.addVariable(new VolVariable(getMathSymbol(membraneVoltage, membraneMapping), nullDomain));
                        }
                        Parameter initialVoltageParm = membraneMapping.getInitialVoltageParameter();
                        Variable initVoltageFunction = newFunctionOrConstant(getMathSymbol(initialVoltageParm, membraneMapping), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), membraneMapping));
                        varHash.addVariable(initVoltageFunction);
                    } else {
                        // 
                        // don't calculate voltage, still may need it though
                        // 
                        Parameter initialVoltageParm = membraneMapping.getInitialVoltageParameter();
                        Variable voltageFunction = newFunctionOrConstant(getMathSymbol(membraneMapping.getMembrane().getMembraneVoltage(), membraneMapping), getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), membraneMapping));
                        varHash.addVariable(voltageFunction);
                    }
                }
            }
        }
    }
    // 
    for (int j = 0; j < reactionSteps.length; j++) {
        ReactionStep rs = reactionSteps[j];
        if (simContext.getReactionContext().getReactionSpec(rs).isExcluded()) {
            continue;
        }
        Kinetics.KineticsParameter[] parameters = rs.getKinetics().getKineticsParameters();
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(rs.getStructure());
        if (parameters != null) {
            for (int i = 0; i < parameters.length; i++) {
                if (((parameters[i].getRole() == Kinetics.ROLE_CurrentDensity) || (parameters[i].getRole() == Kinetics.ROLE_LumpedCurrent)) && (parameters[i].getExpression() == null || parameters[i].getExpression().isZero())) {
                    continue;
                }
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(parameters[i], sm), getIdentifierSubstitutions(parameters[i].getExpression(), parameters[i].getUnitDefinition(), sm)));
            }
        }
    }
    // 
    // initial constants (either function or constant)
    // 
    SpeciesContextSpec[] speciesContextSpecs = simContext.getReactionContext().getSpeciesContextSpecs();
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextSpecParameter initParm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
        if (initParm != null) {
            Expression initExpr = new Expression(initParm.getExpression());
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
            String[] symbols = initExpr.getSymbols();
            // Check if 'initExpr' has other speciesContexts in its expression, need to replace it with 'spContext_init'
            for (int j = 0; symbols != null && j < symbols.length; j++) {
                // if symbol is a speciesContext, replacing it with a reference to initial condition for that speciesContext.
                SpeciesContext spC = null;
                SymbolTableEntry ste = initExpr.getSymbolBinding(symbols[j]);
                if (ste instanceof SpeciesContextSpecProxyParameter) {
                    SpeciesContextSpecProxyParameter spspp = (SpeciesContextSpecProxyParameter) ste;
                    if (spspp.getTarget() instanceof SpeciesContext) {
                        spC = (SpeciesContext) spspp.getTarget();
                        SpeciesContextSpec spcspec = simContext.getReactionContext().getSpeciesContextSpec(spC);
                        SpeciesContextSpecParameter spCInitParm = spcspec.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration);
                        // if initConc param expression is null, try initCount
                        if (spCInitParm.getExpression() == null) {
                            spCInitParm = spcspec.getParameterFromRole(SpeciesContextSpec.ROLE_InitialCount);
                        }
                        // need to get init condn expression, but can't get it from getMathSymbol() (mapping between bio and math), hence get it as below.
                        Expression scsInitExpr = new Expression(spCInitParm, getNameScope());
                        // scsInitExpr.bindExpression(this);
                        initExpr.substituteInPlace(new Expression(spC.getName()), scsInitExpr);
                    }
                }
            }
            // now create the appropriate function for the current speciesContextSpec.
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(initParm, sm), getIdentifierSubstitutions(initExpr, initParm.getUnitDefinition(), sm)));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextMapping scm = getSpeciesContextMapping(speciesContextSpecs[i].getSpeciesContext());
        SpeciesContextSpec.SpeciesContextSpecParameter diffParm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_DiffusionRate);
        if (diffParm != null && (scm.isPDERequired())) {
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(diffParm, sm), getIdentifierSubstitutions(diffParm.getExpression(), diffParm.getUnitDefinition(), sm)));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextSpec.SpeciesContextSpecParameter bc_xm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueXm);
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
        if (bc_xm != null && (bc_xm.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_xm, sm), getIdentifierSubstitutions(bc_xm.getExpression(), bc_xm.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_xp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueXp);
        if (bc_xp != null && (bc_xp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_xp, sm), getIdentifierSubstitutions(bc_xp.getExpression(), bc_xp.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_ym = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueYm);
        if (bc_ym != null && (bc_ym.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_ym, sm), getIdentifierSubstitutions(bc_ym.getExpression(), bc_ym.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_yp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueYp);
        if (bc_yp != null && (bc_yp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_yp, sm), getIdentifierSubstitutions(bc_yp.getExpression(), bc_yp.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_zm = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueZm);
        if (bc_zm != null && (bc_zm.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_zm, sm), getIdentifierSubstitutions(bc_zm.getExpression(), bc_zm.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter bc_zp = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_BoundaryValueZp);
        if (bc_zp != null && (bc_zp.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(bc_zp, sm), getIdentifierSubstitutions(bc_zp.getExpression(), bc_zp.getUnitDefinition(), sm)));
        }
    }
    // 
    for (int i = 0; i < speciesContextSpecs.length; i++) {
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velX = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityX);
        StructureMapping sm = simContext.getGeometryContext().getStructureMapping(speciesContextSpecs[i].getSpeciesContext().getStructure());
        if (advection_velX != null && (advection_velX.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velX, sm), getIdentifierSubstitutions(advection_velX.getExpression(), advection_velX.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velY = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityY);
        if (advection_velY != null && (advection_velY.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velY, sm), getIdentifierSubstitutions(advection_velY.getExpression(), advection_velY.getUnitDefinition(), sm)));
        }
        SpeciesContextSpec.SpeciesContextSpecParameter advection_velZ = speciesContextSpecs[i].getParameterFromRole(SpeciesContextSpec.ROLE_VelocityZ);
        if (advection_velZ != null && (advection_velZ.getExpression() != null)) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(advection_velZ, sm), getIdentifierSubstitutions(advection_velZ.getExpression(), advection_velZ.getUnitDefinition(), sm)));
        }
    }
    // 
    // constant species (either function or constant)
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() instanceof Constant) {
            varHash.addVariable(scm.getVariable());
        }
    }
    // 
    // conversion factors
    // 
    varHash.addVariable(new Constant(getMathSymbol(model.getKMOLE(), null), getIdentifierSubstitutions(model.getKMOLE().getExpression(), model.getKMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getN_PMOLE().getName(), getIdentifierSubstitutions(model.getN_PMOLE().getExpression(), model.getN_PMOLE().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getKMILLIVOLTS().getName(), getIdentifierSubstitutions(model.getKMILLIVOLTS().getExpression(), model.getKMILLIVOLTS().getUnitDefinition(), null)));
    varHash.addVariable(new Constant(model.getK_GHK().getName(), getIdentifierSubstitutions(model.getK_GHK().getExpression(), model.getK_GHK().getUnitDefinition(), null)));
    // 
    // geometric functions
    // 
    ModelUnitSystem modelUnitSystem = simContext.getModel().getUnitSystem();
    VCUnitDefinition lengthInverseUnit = modelUnitSystem.getLengthUnit().getInverse();
    for (int i = 0; i < structureMappings.length; i++) {
        StructureMapping sm = structureMappings[i];
        Parameter parm = sm.getParameterFromRole(StructureMapping.ROLE_VolumeFraction);
        if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
        }
        parm = sm.getParameterFromRole(StructureMapping.ROLE_SurfaceToVolumeRatio);
        if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
        }
        if (sm instanceof MembraneMapping && !getResolved(sm)) {
            MembraneMapping mm = (MembraneMapping) sm;
            parm = ((MembraneMapping) sm).getVolumeFractionParameter();
            if (parm.getExpression() == null) {
                throw new MappingException("volume fraction not specified for feature '" + structTopology.getInsideFeature(mm.getMembrane()).getName() + "', please refer to Structure Mapping in Application '" + simContext.getName() + "'");
            }
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), modelUnitSystem.getInstance_DIMENSIONLESS(), sm)));
            parm = mm.getSurfaceToVolumeParameter();
            if (parm.getExpression() == null) {
                throw new MappingException("surface to volume ratio not specified for membrane '" + mm.getMembrane().getName() + "', please refer to Structure Mapping in Application '" + simContext.getName() + "'");
            }
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), lengthInverseUnit, sm)));
        }
        StructureMappingParameter sizeParm = sm.getSizeParameter();
        if (sizeParm != null) {
            if (simContext.getGeometry().getDimension() == 0) {
                if (sizeParm.getExpression() != null) {
                    try {
                        double value = sizeParm.getExpression().evaluateConstant();
                        varHash.addVariable(new Constant(getMathSymbol(sizeParm, sm), new Expression(value)));
                    } catch (ExpressionException e) {
                        // varHash.addVariable(new Function(getMathSymbol(parm,sm),getIdentifierSubstitutions(parm.getExpression(),parm.getUnitDefinition(),sm)));
                        e.printStackTrace(System.out);
                        throw new MappingException("Size of structure:" + sm.getNameScope().getName() + " cannot be evaluated as constant.");
                    }
                }
            } else {
                String compartmentName = null;
                VCUnitDefinition sizeUnit = sm.getSizeParameter().getUnitDefinition();
                String sizeFunctionName = null;
                if (sm instanceof MembraneMapping) {
                    MembraneMapping mm = (MembraneMapping) sm;
                    if (getResolved(mm)) {
                        FeatureMapping fm_inside = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getInsideFeature(mm.getMembrane()));
                        FeatureMapping fm_outside = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getOutsideFeature(mm.getMembrane()));
                        compartmentName = getSubVolume(fm_inside).getName() + "_" + getSubVolume(fm_outside).getName();
                        sizeFunctionName = MathFunctionDefinitions.Function_regionArea_current.getFunctionName();
                    } else {
                        FeatureMapping fm_inside = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getInsideFeature(mm.getMembrane()));
                        FeatureMapping fm_outside = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getOutsideFeature(mm.getMembrane()));
                        if (getSubVolume(fm_inside) == getSubVolume(fm_outside)) {
                            compartmentName = getSubVolume(fm_inside).getName();
                            sizeFunctionName = MathFunctionDefinitions.Function_regionVolume_current.getFunctionName();
                        } else {
                            throw new RuntimeException("unexpected structure mapping for membrane '" + mm.getMembrane().getName() + "'");
                        }
                    }
                } else if (sm instanceof FeatureMapping) {
                    FeatureMapping fm = (FeatureMapping) sm;
                    compartmentName = getSubVolume(fm).getName();
                    sizeFunctionName = MathFunctionDefinitions.Function_regionVolume_current.getFunctionName();
                } else {
                    throw new RuntimeException("structure mapping " + sm.getClass().getName() + " not yet supported");
                }
                Expression totalVolumeCorrection = sm.getStructureSizeCorrection(simContext, this);
                Expression sizeFunctionExpression = Expression.function(sizeFunctionName, new Expression[] { new Expression("'" + compartmentName + "'") });
                sizeFunctionExpression.bindExpression(mathDesc);
                varHash.addVariable(newFunctionOrConstant(getMathSymbol(sizeParm, sm), getIdentifierSubstitutions(Expression.mult(totalVolumeCorrection, sizeFunctionExpression), sizeUnit, sm)));
                parm = sm.getParameterFromRole(StructureMapping.ROLE_AreaPerUnitArea);
                if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SurfaceClass) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
                }
                parm = sm.getParameterFromRole(StructureMapping.ROLE_AreaPerUnitVolume);
                if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
                }
                parm = sm.getParameterFromRole(StructureMapping.ROLE_VolumePerUnitArea);
                if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SurfaceClass) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
                }
                parm = sm.getParameterFromRole(StructureMapping.ROLE_VolumePerUnitVolume);
                if (parm != null && parm.getExpression() != null && sm.getGeometryClass() instanceof SubVolume) {
                    varHash.addVariable(newFunctionOrConstant(getMathSymbol(parm, sm), getIdentifierSubstitutions(parm.getExpression(), parm.getUnitDefinition(), sm)));
                }
            }
        }
    }
    // 
    for (int i = 0; i < fieldMathMappingParameters.length; i++) {
        varHash.addVariable(newFunctionOrConstant(getMathSymbol(fieldMathMappingParameters[i], null), getIdentifierSubstitutions(fieldMathMappingParameters[i].getExpression(), fieldMathMappingParameters[i].getUnitDefinition(), null)));
    }
    // 
    // functions
    // 
    enum1 = getSpeciesContextMappings();
    while (enum1.hasMoreElements()) {
        SpeciesContextMapping scm = (SpeciesContextMapping) enum1.nextElement();
        if (scm.getVariable() == null && scm.getDependencyExpression() != null) {
            StructureMapping sm = simContext.getGeometryContext().getStructureMapping(scm.getSpeciesContext().getStructure());
            varHash.addVariable(newFunctionOrConstant(getMathSymbol(scm.getSpeciesContext(), sm), getIdentifierSubstitutions(scm.getDependencyExpression(), scm.getSpeciesContext().getUnitDefinition(), sm)));
        }
    }
    // 
    // set Variables to MathDescription all at once with the order resolved by "VariableHash"
    // 
    mathDesc.setAllVariables(varHash.getAlphabeticallyOrderedVariables());
    // 
    if (simContext.getGeometryContext().getGeometry() != null) {
        try {
            mathDesc.setGeometry(simContext.getGeometryContext().getGeometry());
        } catch (java.beans.PropertyVetoException e) {
            e.printStackTrace(System.out);
            throw new MappingException("failure setting geometry " + e.getMessage());
        }
    } else {
        throw new MappingException("geometry must be defined");
    }
    // 
    // volume subdomains
    // 
    subVolumes = simContext.getGeometryContext().getGeometry().getGeometrySpec().getSubVolumes();
    VCUnitDefinition timeUnit = modelUnitSystem.getTimeUnit();
    for (int j = 0; j < subVolumes.length; j++) {
        SubVolume subVolume = (SubVolume) subVolumes[j];
        // 
        // get priority of subDomain
        // 
        int priority;
        Feature spatialFeature = getResolvedFeature(subVolume);
        if (spatialFeature == null) {
            if (simContext.getGeometryContext().getGeometry().getDimension() > 0) {
                throw new MappingException("no compartment (in Physiology) is mapped to subdomain '" + subVolume.getName() + "' (in Geometry)");
            } else {
                priority = CompartmentSubDomain.NON_SPATIAL_PRIORITY;
            }
        } else {
            // now does not have to match spatial feature, *BUT* needs to be unique
            priority = j;
        }
        // 
        // create subDomain
        // 
        CompartmentSubDomain subDomain = new CompartmentSubDomain(subVolume.getName(), priority);
        mathDesc.addSubDomain(subDomain);
        // 
        if (spatialFeature != null) {
            FeatureMapping fm = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(spatialFeature);
            subDomain.setBoundaryConditionXm(fm.getBoundaryConditionTypeXm());
            subDomain.setBoundaryConditionXp(fm.getBoundaryConditionTypeXp());
            if (simContext.getGeometry().getDimension() > 1) {
                subDomain.setBoundaryConditionYm(fm.getBoundaryConditionTypeYm());
                subDomain.setBoundaryConditionYp(fm.getBoundaryConditionTypeYp());
            }
            if (simContext.getGeometry().getDimension() > 2) {
                subDomain.setBoundaryConditionZm(fm.getBoundaryConditionTypeZm());
                subDomain.setBoundaryConditionZp(fm.getBoundaryConditionTypeZp());
            }
        }
        // 
        // create equations
        // 
        VolumeStructureAnalyzer structureAnalyzer = getVolumeStructureAnalyzer(subVolume);
        Enumeration<SpeciesContextMapping> enumSCM = getSpeciesContextMappings();
        while (enumSCM.hasMoreElements()) {
            SpeciesContextMapping scm = enumSCM.nextElement();
            // 
            if (scm.getVariable() instanceof VolVariable && scm.getDependencyExpression() == null) {
                SpeciesContext sc = scm.getSpeciesContext();
                StructureMapping sm = simContext.getGeometryContext().getStructureMapping(sc.getStructure());
                SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
                VolVariable variable = (VolVariable) scm.getVariable();
                Equation equation = null;
                if ((scm.isPDERequired()) && sm instanceof FeatureMapping) {
                    // 
                    if (getSubVolume((FeatureMapping) sm) == subVolume) {
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), sm));
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()));
                        Expression diffusion = new Expression(getMathSymbol(scs.getDiffusionParameter(), sm));
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        ((PdeEquation) equation).setBoundaryXm((scs.getBoundaryXmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXmParameter(), sm)));
                        ((PdeEquation) equation).setBoundaryXp((scs.getBoundaryXpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXpParameter(), sm)));
                        ((PdeEquation) equation).setBoundaryYm((scs.getBoundaryYmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYmParameter(), sm)));
                        ((PdeEquation) equation).setBoundaryYp((scs.getBoundaryYpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYpParameter(), sm)));
                        ((PdeEquation) equation).setBoundaryZm((scs.getBoundaryZmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZmParameter(), sm)));
                        ((PdeEquation) equation).setBoundaryZp((scs.getBoundaryZpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZpParameter(), sm)));
                        ((PdeEquation) equation).setVelocityX((scs.getVelocityXParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getVelocityXParameter(), sm)));
                        ((PdeEquation) equation).setVelocityY((scs.getVelocityYParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getVelocityYParameter(), sm)));
                        ((PdeEquation) equation).setVelocityZ((scs.getVelocityZParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getVelocityZParameter(), sm)));
                        subDomain.replaceEquation(equation);
                    } else {
                        Expression initial = new Expression(0.0);
                        Expression rate = new Expression(0.0);
                        Expression diffusion = new Expression(getMathSymbol(scs.getDiffusionParameter(), sm));
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        if (subDomain.getEquation(variable) == null) {
                            subDomain.addEquation(equation);
                        }
                    }
                } else {
                    // 
                    // ODE
                    // 
                    SubVolume mappedSubVolume = null;
                    if (sm instanceof FeatureMapping) {
                        mappedSubVolume = getSubVolume((FeatureMapping) sm);
                    } else if (sm instanceof MembraneMapping) {
                        // membrane is mapped to that of the inside feature
                        FeatureMapping featureMapping = (FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getInsideFeature((Membrane) sm.getStructure()));
                        mappedSubVolume = getSubVolume(featureMapping);
                    }
                    if (mappedSubVolume == subVolume) {
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), null));
                        Expression rate = (scm.getRate() == null) ? new Expression(0.0) : getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()));
                        equation = new OdeEquation(variable, initial, rate);
                        subDomain.replaceEquation(equation);
                    } else {
                        Expression initial = new Expression(0.0);
                        Expression rate = new Expression(0.0);
                        equation = new OdeEquation(variable, initial, rate);
                        if (subDomain.getEquation(variable) == null) {
                            subDomain.addEquation(equation);
                        }
                    }
                }
            }
        }
        // 
        // create fast system (if neccessary)
        // 
        SpeciesContextMapping[] fastSpeciesContextMappings = structureAnalyzer.getFastSpeciesContextMappings();
        VCUnitDefinition subDomainUnit = modelUnitSystem.getVolumeConcentrationUnit();
        if (fastSpeciesContextMappings != null) {
            FastSystem fastSystem = new FastSystem(mathDesc);
            for (int i = 0; i < fastSpeciesContextMappings.length; i++) {
                SpeciesContextMapping scm = fastSpeciesContextMappings[i];
                if (scm.getFastInvariant() == null) {
                    // 
                    // independant-fast variable, create a fastRate object
                    // 
                    Expression rate = getIdentifierSubstitutions(scm.getFastRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(getResolvedFeature(subVolume)));
                    FastRate fastRate = new FastRate(rate);
                    fastSystem.addFastRate(fastRate);
                } else {
                    // 
                    // dependant-fast variable, create a fastInvariant object
                    // 
                    Expression rate = getIdentifierSubstitutions(scm.getFastInvariant(), subDomainUnit, simContext.getGeometryContext().getStructureMapping(getResolvedFeature(subVolume)));
                    FastInvariant fastInvariant = new FastInvariant(rate);
                    fastSystem.addFastInvariant(fastInvariant);
                }
            }
            subDomain.setFastSystem(fastSystem);
            // constructor calls the 'refresh' method which constructs depemdency matrix, dependent/independent vars and pseudoconstants, etc.
            FastSystemAnalyzer fs_analyzer = new FastSystemAnalyzer(fastSystem, mathDesc);
        }
        // 
        // create ode's for voltages to be calculated on unresolved membranes mapped to this subVolume
        // 
        Structure[] localStructures = getStructures(subVolume);
        for (int sIndex = 0; sIndex < localStructures.length; sIndex++) {
            if (localStructures[sIndex] instanceof Membrane) {
                Membrane membrane = (Membrane) localStructures[sIndex];
                MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membrane);
                if (!getResolved(membraneMapping) && membraneMapping.getCalculateVoltage()) {
                    MembraneElectricalDevice capacitiveDevice = potentialMapping.getCapacitiveDevice(membrane);
                    if (capacitiveDevice.getDependentVoltageExpression() == null) {
                        VolVariable vVar = (VolVariable) mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping));
                        Expression initExp = new Expression(getMathSymbol(capacitiveDevice.getMembraneMapping().getInitialVoltageParameter(), membraneMapping));
                        subDomain.addEquation(new OdeEquation(vVar, initExp, getIdentifierSubstitutions(potentialMapping.getOdeRHS(capacitiveDevice, this), membrane.getMembraneVoltage().getUnitDefinition().divideBy(timeUnit), membraneMapping)));
                    } else {
                    // 
                    // 
                    // 
                    }
                }
            }
        }
    }
    // 
    for (int k = 0; k < subVolumes.length; k++) {
        SubVolume subVolume = (SubVolume) subVolumes[k];
        // 
        // if there is a spatially resolved membrane surrounding this subVolume, then create a membraneSubDomain
        // 
        structures = getStructures(subVolume);
        Membrane membrane = null;
        if (structures != null) {
            for (int j = 0; j < structures.length; j++) {
                if (structures[j] instanceof Membrane && getResolved(simContext.getGeometryContext().getStructureMapping(structures[j]))) {
                    membrane = (Membrane) structures[j];
                }
            }
        }
        if (membrane == null) {
            continue;
        }
        SubVolume outerSubVolume = getSubVolume(((FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getOutsideFeature(membrane))));
        SubVolume innerSubVolume = getSubVolume(((FeatureMapping) simContext.getGeometryContext().getStructureMapping(structTopology.getInsideFeature(membrane))));
        if (innerSubVolume != subVolume) {
            throw new MappingException("membrane " + membrane.getName() + " improperly mapped to inner subVolume " + innerSubVolume.getName());
        }
        // 
        // get priority of subDomain
        // 
        // Feature spatialFeature = simContext.getGeometryContext().getResolvedFeature(subVolume);
        // int priority = spatialFeature.getPriority();
        // 
        // create subDomain
        // 
        CompartmentSubDomain outerCompartment = mathDesc.getCompartmentSubDomain(outerSubVolume.getName());
        CompartmentSubDomain innerCompartment = mathDesc.getCompartmentSubDomain(innerSubVolume.getName());
        SurfaceClass surfaceClass = simContext.getGeometry().getGeometrySurfaceDescription().getSurfaceClass(innerSubVolume, outerSubVolume);
        MembraneSubDomain memSubDomain = new MembraneSubDomain(innerCompartment, outerCompartment, surfaceClass.getName());
        mathDesc.addSubDomain(memSubDomain);
        // 
        // create equations for membrane-bound molecular species
        // 
        MembraneStructureAnalyzer membraneStructureAnalyzer = getMembraneStructureAnalyzer(membrane);
        Enumeration<SpeciesContextMapping> enumSCM = getSpeciesContextMappings();
        while (enumSCM.hasMoreElements()) {
            SpeciesContextMapping scm = enumSCM.nextElement();
            SpeciesContext sc = scm.getSpeciesContext();
            SpeciesContextSpec scs = simContext.getReactionContext().getSpeciesContextSpec(sc);
            // 
            if ((scm.getVariable() instanceof MemVariable) && scm.getDependencyExpression() == null) {
                // 
                // independant variable, create an equation object
                // 
                Equation equation = null;
                MemVariable variable = (MemVariable) scm.getVariable();
                MembraneMapping mm = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(sc.getStructure());
                if (scm.isPDERequired()) {
                    // 
                    if (mm.getMembrane() == membrane) {
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), mm));
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()));
                        Expression diffusion = new Expression(getMathSymbol(scs.getDiffusionParameter(), mm));
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        ((PdeEquation) equation).setBoundaryXm((scs.getBoundaryXmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXmParameter(), mm)));
                        ((PdeEquation) equation).setBoundaryXp((scs.getBoundaryXpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryXpParameter(), mm)));
                        ((PdeEquation) equation).setBoundaryYm((scs.getBoundaryYmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYmParameter(), mm)));
                        ((PdeEquation) equation).setBoundaryYp((scs.getBoundaryYpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryYpParameter(), mm)));
                        ((PdeEquation) equation).setBoundaryZm((scs.getBoundaryZmParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZmParameter(), mm)));
                        ((PdeEquation) equation).setBoundaryZp((scs.getBoundaryZpParameter().getExpression() == null) ? (null) : new Expression(getMathSymbol(scs.getBoundaryZpParameter(), mm)));
                        memSubDomain.replaceEquation(equation);
                    } else {
                        Expression initial = new Expression(0.0);
                        Expression rate = new Expression(0.0);
                        Expression diffusion = new Expression(getMathSymbol(scs.getDiffusionParameter(), mm));
                        equation = new PdeEquation(variable, initial, rate, diffusion);
                        if (memSubDomain.getEquation(variable) == null) {
                            memSubDomain.addEquation(equation);
                        }
                    }
                } else {
                    // 
                    if (mm.getMembrane() == membrane) {
                        // 
                        // species context belongs to this subDomain
                        // 
                        Expression initial = new Expression(getMathSymbol(scs.getParameterFromRole(SpeciesContextSpec.ROLE_InitialConcentration), null));
                        Expression rate = getIdentifierSubstitutions(scm.getRate(), scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit), simContext.getGeometryContext().getStructureMapping(sc.getStructure()));
                        equation = new OdeEquation(variable, initial, rate);
                        memSubDomain.replaceEquation(equation);
                    } else {
                        Expression initial = new Expression(0.0);
                        Expression rate = new Expression(0.0);
                        equation = new OdeEquation(variable, initial, rate);
                        if (memSubDomain.getEquation(variable) == null) {
                            memSubDomain.addEquation(equation);
                        }
                    }
                }
            }
        }
        // 
        // create dummy jump conditions for all volume variables that diffuse and/or advect
        // 
        Enumeration<SpeciesContextMapping> enum_scm = getSpeciesContextMappings();
        while (enum_scm.hasMoreElements()) {
            SpeciesContextMapping scm = enum_scm.nextElement();
            if (scm.isPDERequired()) {
                // Species species = scm.getSpeciesContext().getSpecies();
                Variable var = scm.getVariable();
                if (var instanceof VolVariable && (scm.isPDERequired())) {
                    JumpCondition jc = memSubDomain.getJumpCondition((VolVariable) var);
                    if (jc == null) {
                        // System.out.println("MathMapping.refreshMathDescription(), adding jump condition for diffusing variable "+var.getName()+" on membrane "+membraneStructureAnalyzer.getMembrane().getName());
                        jc = new JumpCondition((VolVariable) var);
                        memSubDomain.addJumpCondition(jc);
                    }
                }
            }
        }
        // 
        // create jump conditions for any volume variables that bind to membrane or have explicitly defined fluxes
        // 
        ResolvedFlux[] resolvedFluxes = membraneStructureAnalyzer.getResolvedFluxes();
        if (resolvedFluxes != null) {
            for (int i = 0; i < resolvedFluxes.length; i++) {
                Species species = resolvedFluxes[i].getSpecies();
                SpeciesContext sc = simContext.getReactionContext().getModel().getSpeciesContext(species, structTopology.getInsideFeature(membraneStructureAnalyzer.getMembrane()));
                if (sc == null) {
                    sc = simContext.getReactionContext().getModel().getSpeciesContext(species, structTopology.getOutsideFeature(membraneStructureAnalyzer.getMembrane()));
                }
                SpeciesContextMapping scm = getSpeciesContextMapping(sc);
                // if (scm.getVariable() instanceof VolVariable && scm.isDiffusing()){
                if (scm.getVariable() instanceof VolVariable && ((MembraneStructureAnalyzer.bNoFluxIfFixed || (scm.isPDERequired())))) {
                    if (MembraneStructureAnalyzer.bNoFluxIfFixed && !scm.isPDERequired()) {
                        MembraneStructureAnalyzer.bNoFluxIfFixedExercised = true;
                    }
                    JumpCondition jc = memSubDomain.getJumpCondition((VolVariable) scm.getVariable());
                    if (jc == null) {
                        jc = new JumpCondition((VolVariable) scm.getVariable());
                        memSubDomain.addJumpCondition(jc);
                    }
                    Expression inFlux = getIdentifierSubstitutions(resolvedFluxes[i].inFluxExpression, resolvedFluxes[i].getUnitDefinition(), simContext.getGeometryContext().getStructureMapping(membraneStructureAnalyzer.getMembrane()));
                    jc.setInFlux(inFlux);
                    Expression outFlux = getIdentifierSubstitutions(resolvedFluxes[i].outFluxExpression, resolvedFluxes[i].getUnitDefinition(), simContext.getGeometryContext().getStructureMapping(membraneStructureAnalyzer.getMembrane()));
                    jc.setOutFlux(outFlux);
                } else {
                    throw new MappingException("APPLICATION  " + simContext.getName() + " : " + scm.getSpeciesContext().getName() + " has spatially resolved flux at membrane " + membrane.getName() + ", but doesn't diffuse in compartment " + scm.getSpeciesContext().getStructure().getName());
                }
            }
        }
        // 
        // create fast system (if neccessary)
        // 
        SpeciesContextMapping[] fastSpeciesContextMappings = membraneStructureAnalyzer.getFastSpeciesContextMappings();
        if (fastSpeciesContextMappings != null) {
            FastSystem fastSystem = new FastSystem(mathDesc);
            for (int i = 0; i < fastSpeciesContextMappings.length; i++) {
                SpeciesContextMapping scm = fastSpeciesContextMappings[i];
                if (scm.getFastInvariant() == null) {
                    // 
                    // independant-fast variable, create a fastRate object
                    // 
                    VCUnitDefinition rateUnit = scm.getSpeciesContext().getUnitDefinition().divideBy(timeUnit);
                    MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membraneStructureAnalyzer.getMembrane());
                    FastRate fastRate = new FastRate(getIdentifierSubstitutions(scm.getFastRate(), rateUnit, membraneMapping));
                    fastSystem.addFastRate(fastRate);
                } else {
                    // 
                    // dependant-fast variable, create a fastInvariant object
                    // 
                    VCUnitDefinition invariantUnit = scm.getSpeciesContext().getUnitDefinition();
                    MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membraneStructureAnalyzer.getMembrane());
                    FastInvariant fastInvariant = new FastInvariant(getIdentifierSubstitutions(scm.getFastInvariant(), invariantUnit, membraneMapping));
                    fastSystem.addFastInvariant(fastInvariant);
                }
            }
            memSubDomain.setFastSystem(fastSystem);
            // constructor calls the 'refresh' method which constructs depemdency matrix, dependent/independent vars and pseudoconstants, etc.
            FastSystemAnalyzer fs_analyzer = new FastSystemAnalyzer(fastSystem, mathDesc);
        }
        // 
        // create Membrane-region equations for potential of this resolved membrane
        // 
        MembraneMapping membraneMapping = (MembraneMapping) simContext.getGeometryContext().getStructureMapping(membrane);
        if (membraneMapping.getCalculateVoltage()) {
            ElectricalDevice[] membraneDevices = potentialMapping.getElectricalDevices(membrane);
            int numCapacitiveDevices = 0;
            MembraneElectricalDevice capacitiveDevice = null;
            for (int i = 0; i < membraneDevices.length; i++) {
                if (membraneDevices[i] instanceof MembraneElectricalDevice) {
                    numCapacitiveDevices++;
                    capacitiveDevice = (MembraneElectricalDevice) membraneDevices[i];
                }
            }
            if (numCapacitiveDevices != 1) {
                throw new MappingException("expecting 1 capacitive electrical device on graph edge for membrane " + membrane.getName() + ", found '" + numCapacitiveDevices + "'");
            }
            if (mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping)) instanceof MembraneRegionVariable) {
                MembraneRegionVariable vVar = (MembraneRegionVariable) mathDesc.getVariable(getMathSymbol(capacitiveDevice.getVoltageSymbol(), membraneMapping));
                Parameter initialVoltageParm = capacitiveDevice.getMembraneMapping().getInitialVoltageParameter();
                Expression initExp = getIdentifierSubstitutions(initialVoltageParm.getExpression(), initialVoltageParm.getUnitDefinition(), capacitiveDevice.getMembraneMapping());
                MembraneRegionEquation vEquation = new MembraneRegionEquation(vVar, initExp);
                vEquation.setMembraneRateExpression(getIdentifierSubstitutions(potentialMapping.getOdeRHS(capacitiveDevice, this), membrane.getMembraneVoltage().getUnitDefinition().divideBy(timeUnit), capacitiveDevice.getMembraneMapping()));
                memSubDomain.addEquation(vEquation);
            }
        }
    }
    // create equations for event assign targets that are model params/strutureSize, etc.
    Set<VolVariable> hashKeySet = eventVolVarHash.keySet();
    Iterator<VolVariable> volVarsIter = hashKeySet.iterator();
    // working under teh assumption that we are dealing with non-spatial math, hence only one compartment domain!
    SubDomain subDomain = mathDesc.getSubDomains().nextElement();
    while (volVarsIter.hasNext()) {
        VolVariable volVar = volVarsIter.next();
        EventAssignmentInitParameter eap = eventVolVarHash.get(volVar);
        Expression rateExpr = new Expression(0.0);
        Equation equation = new OdeEquation(volVar, new Expression(getMathSymbol(eap, null)), rateExpr);
        subDomain.addEquation(equation);
    }
    // events - add events to math desc and odes for event assignments that have parameters as target variables
    BioEvent[] bioevents = simContext.getBioEvents();
    if (bioevents != null && bioevents.length > 0) {
        for (BioEvent be : bioevents) {
            // transform the bioEvent trigger/delay to math Event
            Expression mathTriggerExpr = getIdentifierSubstitutions(be.generateTriggerExpression(), modelUnitSystem.getInstance_DIMENSIONLESS(), null);
            Delay mathDelay = null;
            if (be.getParameter(BioEventParameterType.TriggerDelay) != null) {
                boolean bUseValsFromTriggerTime = be.getUseValuesFromTriggerTime();
                Expression mathDelayExpr = getIdentifierSubstitutions(be.getParameter(BioEventParameterType.TriggerDelay).getExpression(), timeUnit, null);
                mathDelay = new Delay(bUseValsFromTriggerTime, mathDelayExpr);
            }
            // now deal with (bio)event Assignment translation to math EventAssignment
            ArrayList<EventAssignment> eventAssignments = be.getEventAssignments();
            ArrayList<Event.EventAssignment> mathEventAssignmentsList = new ArrayList<Event.EventAssignment>();
            for (EventAssignment ea : eventAssignments) {
                SymbolTableEntry ste = simContext.getEntry(ea.getTarget().getName());
                VCUnitDefinition eventAssignVarUnit = ste.getUnitDefinition();
                Variable variable = varHash.getVariable(ste.getName());
                Event.EventAssignment mathEA = new Event.EventAssignment(variable, getIdentifierSubstitutions(ea.getAssignmentExpression(), eventAssignVarUnit, null));
                mathEventAssignmentsList.add(mathEA);
            }
            // use the translated trigger, delay and event assignments to create (math) event
            Event mathEvent = new Event(be.getName(), mathTriggerExpr, mathDelay, mathEventAssignmentsList);
            mathDesc.addEvent(mathEvent);
        }
    }
    if (!mathDesc.isValid()) {
        throw new MappingException("generated an invalid mathDescription: " + mathDesc.getWarning());
    }
// System.out.println("]]]]]]]]]]]]]]]]]]]]]] VCML string begin ]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]");
// System.out.println(mathDesc.getVCML());
// System.out.println("]]]]]]]]]]]]]]]]]]]]]] VCML string end ]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]");
}
Also used : MembraneMapping(cbit.vcell.mapping.MembraneMapping) MembraneSubDomain(cbit.vcell.math.MembraneSubDomain) ArrayList(java.util.ArrayList) SpeciesContext(cbit.vcell.model.SpeciesContext) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) Feature(cbit.vcell.model.Feature) MemVariable(cbit.vcell.math.MemVariable) KineticsParameter(cbit.vcell.model.Kinetics.KineticsParameter) SubVolume(cbit.vcell.geometry.SubVolume) Vector(java.util.Vector) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) StructureTopology(cbit.vcell.model.Model.StructureTopology) ReactionSpec(cbit.vcell.mapping.ReactionSpec) FastInvariant(cbit.vcell.math.FastInvariant) PropertyVetoException(java.beans.PropertyVetoException) VCUnitDefinition(cbit.vcell.units.VCUnitDefinition) FastSystem(cbit.vcell.math.FastSystem) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) ReactionStep(cbit.vcell.model.ReactionStep) MembraneRegionEquation(cbit.vcell.math.MembraneRegionEquation) SurfaceClass(cbit.vcell.geometry.SurfaceClass) VariableHash(cbit.vcell.math.VariableHash) StructureMapping(cbit.vcell.mapping.StructureMapping) FeatureMapping(cbit.vcell.mapping.FeatureMapping) Structure(cbit.vcell.model.Structure) ModelUnitSystem(cbit.vcell.model.ModelUnitSystem) Hashtable(java.util.Hashtable) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) Expression(cbit.vcell.parser.Expression) Model(cbit.vcell.model.Model) ProxyParameter(cbit.vcell.model.ProxyParameter) StructureMappingParameter(cbit.vcell.mapping.StructureMapping.StructureMappingParameter) Parameter(cbit.vcell.model.Parameter) KineticsParameter(cbit.vcell.model.Kinetics.KineticsParameter) SpeciesContextSpecProxyParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecProxyParameter) LocalParameter(cbit.vcell.mapping.ParameterContext.LocalParameter) ModelParameter(cbit.vcell.model.Model.ModelParameter) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) BioEvent(cbit.vcell.mapping.BioEvent) Event(cbit.vcell.math.Event) BioEvent(cbit.vcell.mapping.BioEvent) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) MathDescription(cbit.vcell.math.MathDescription) SpeciesContextMapping(cbit.vcell.mapping.SpeciesContextMapping) SpeciesContextSpec(cbit.vcell.mapping.SpeciesContextSpec) ExpressionException(cbit.vcell.parser.ExpressionException) Delay(cbit.vcell.math.Event.Delay) MappingException(cbit.vcell.mapping.MappingException) PropertyVetoException(java.beans.PropertyVetoException) PdeEquation(cbit.vcell.math.PdeEquation) CompartmentSubDomain(cbit.vcell.math.CompartmentSubDomain) SubDomain(cbit.vcell.math.SubDomain) MembraneSubDomain(cbit.vcell.math.MembraneSubDomain) Species(cbit.vcell.model.Species) SpeciesContextSpecParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecParameter) EventAssignment(cbit.vcell.mapping.BioEvent.EventAssignment) VolVariable(cbit.vcell.math.VolVariable) ModelParameter(cbit.vcell.model.Model.ModelParameter) OdeEquation(cbit.vcell.math.OdeEquation) JumpCondition(cbit.vcell.math.JumpCondition) MembraneRegionVariable(cbit.vcell.math.MembraneRegionVariable) VolVariable(cbit.vcell.math.VolVariable) MemVariable(cbit.vcell.math.MemVariable) Variable(cbit.vcell.math.Variable) SpeciesContextSpecProxyParameter(cbit.vcell.mapping.SpeciesContextSpec.SpeciesContextSpecProxyParameter) Constant(cbit.vcell.math.Constant) SymbolTableEntry(cbit.vcell.parser.SymbolTableEntry) Membrane(cbit.vcell.model.Membrane) EventAssignment(cbit.vcell.mapping.BioEvent.EventAssignment) OdeEquation(cbit.vcell.math.OdeEquation) MembraneRegionEquation(cbit.vcell.math.MembraneRegionEquation) PdeEquation(cbit.vcell.math.PdeEquation) Equation(cbit.vcell.math.Equation) FastRate(cbit.vcell.math.FastRate)

Aggregations

MembraneRegionVariable (cbit.vcell.math.MembraneRegionVariable)15 MemVariable (cbit.vcell.math.MemVariable)13 VolVariable (cbit.vcell.math.VolVariable)13 VolumeRegionVariable (cbit.vcell.math.VolumeRegionVariable)12 Variable (cbit.vcell.math.Variable)10 Expression (cbit.vcell.parser.Expression)10 FilamentVariable (cbit.vcell.math.FilamentVariable)8 MembraneSubDomain (cbit.vcell.math.MembraneSubDomain)8 CompartmentSubDomain (cbit.vcell.math.CompartmentSubDomain)7 FilamentRegionVariable (cbit.vcell.math.FilamentRegionVariable)7 SubDomain (cbit.vcell.math.SubDomain)7 Constant (cbit.vcell.math.Constant)6 MathDescription (cbit.vcell.math.MathDescription)6 ReservedVariable (cbit.vcell.math.ReservedVariable)6 InsideVariable (cbit.vcell.math.InsideVariable)5 OutsideVariable (cbit.vcell.math.OutsideVariable)5 Equation (cbit.vcell.math.Equation)4 Function (cbit.vcell.math.Function)4 MembraneRegionEquation (cbit.vcell.math.MembraneRegionEquation)4 PdeEquation (cbit.vcell.math.PdeEquation)4