use of cbit.vcell.mapping.SimulationContext.MathMappingCallback in project vcell by virtualcell.
the class ParameterEstimationRunTaskPanel method solve.
private void solve() throws NumberFormatException {
CopasiOptimizationMethod com = optimizationMethodParameterTableModel.copasiOptimizationMethod;
OptimizationSolverSpec optSolverSpec = new OptimizationSolverSpec(com);
// get num runs for stochstic opt mehtods before starting solving...
if (com.getType().isStochasticMethod()) {
int numRuns = Integer.parseInt(((String) numberOfRunComboBox.getSelectedItem()));
optSolverSpec.setNumOfRuns(numRuns);
}
parameterEstimationTask.setOptimizationSolverSpec(optSolverSpec);
parameterEstimationTask.getModelOptimizationSpec().setComputeProfileDistributions(computeProfileDistributionsCheckBox.isSelected());
optSolverCallbacks.reset();
Double endValue = com.getEndValue();
optSolverCallbacks.setEvaluation(0, Double.POSITIVE_INFINITY, 0, endValue, 0);
// (endValue != null);
getRunStatusDialog().showProgressBar(com);
Collection<AsynchClientTask> taskList = ClientRequestManager.updateMath(this, parameterEstimationTask.getSimulationContext(), false, NetworkGenerationRequirements.ComputeFullStandardTimeout);
AsynchClientTask task1 = new AsynchClientTask("checking issues", AsynchClientTask.TASKTYPE_NONSWING_BLOCKING) {
@Override
public void run(Hashtable<String, Object> hashTable) throws Exception {
StringBuffer issueText = new StringBuffer();
java.util.Vector<Issue> issueList = new java.util.Vector<Issue>();
IssueContext issueContext = new IssueContext();
parameterEstimationTask.gatherIssues(issueContext, issueList);
boolean bFailed = false;
for (int i = 0; i < issueList.size(); i++) {
Issue issue = (Issue) issueList.elementAt(i);
issueText.append(issue.getMessage() + "\n");
if (issue.getSeverity() == Issue.SEVERITY_ERROR) {
bFailed = true;
break;
}
}
if (bFailed) {
throw new OptimizationException(issueText.toString());
}
parameterEstimationTask.refreshMappings();
}
};
taskList.add(task1);
AsynchClientTask task2 = new AsynchClientTask("solving", AsynchClientTask.TASKTYPE_NONSWING_BLOCKING) {
@Override
public void run(Hashtable<String, Object> hashTable) throws Exception {
MathMappingCallback mathMappingCallback = new MathMappingCallbackTaskAdapter(getClientTaskStatusSupport());
// OptimizationResultSet optResultSet = CopasiOptimizationSolver.solveLocalPython(new ParameterEstimationTaskSimulatorIDA(),parameterEstimationTask,optSolverCallbacks,mathMappingCallback);
OptimizationResultSet optResultSet = CopasiOptimizationSolver.solveRemoteApi(new ParameterEstimationTaskSimulatorIDA(), parameterEstimationTask, optSolverCallbacks, mathMappingCallback);
hashTable.put(ORS_KEY, optResultSet);
}
};
taskList.add(task2);
AsynchClientTask setResultTask = new AsynchClientTask("set results", AsynchClientTask.TASKTYPE_SWING_BLOCKING) {
@Override
public void run(Hashtable<String, Object> hashTable) throws Exception {
OptimizationResultSet optResultSet = (OptimizationResultSet) hashTable.get(ORS_KEY);
parameterEstimationTask.setOptimizationResultSet(optResultSet);
}
};
taskList.add(setResultTask);
ClientTaskDispatcher.dispatch(this, new Hashtable<String, Object>(), taskList.toArray(new AsynchClientTask[taskList.size()]), getRunStatusDialog(), true, true, true, null, false);
}
use of cbit.vcell.mapping.SimulationContext.MathMappingCallback in project vcell by virtualcell.
the class StandaloneSEDMLTest method doit.
public static void doit(File archiveFile) throws Exception {
ArchiveComponents ac = null;
ac = Libsedml.readSEDMLArchive(new FileInputStream(archiveFile));
SEDMLDocument sedmlDoc = ac.getSedmlDocument();
SedML sedml = sedmlDoc.getSedMLModel();
if (sedml == null || sedml.getModels().isEmpty()) {
throw new RuntimeException("sedml null or empty");
}
ModelResolver resolver = new ModelResolver(sedml);
// resolver.add(new FileModelResolver());
resolver.add(new ArchiveModelResolver(ac));
resolver.add(new BioModelsModelsRetriever());
resolver.add(new URLResourceRetriever());
// resolver.add(new RelativeFileModelResolver(FileUtils.getFullPath(archiveFile.getAbsolutePath())));
//
// iterate through all the elements and show them at the console
//
List<org.jlibsedml.Model> mmm = sedml.getModels();
for (Model mm : mmm) {
System.out.println(mm.toString());
}
List<org.jlibsedml.Simulation> sss = sedml.getSimulations();
for (org.jlibsedml.Simulation ss : sss) {
System.out.println(ss.toString());
}
List<AbstractTask> ttt = sedml.getTasks();
for (AbstractTask tt : ttt) {
System.out.println(tt.toString());
}
List<DataGenerator> ddd = sedml.getDataGenerators();
for (DataGenerator dd : ddd) {
System.out.println(dd.toString());
}
List<Output> ooo = sedml.getOutputs();
for (Output oo : ooo) {
System.out.println(oo.toString());
}
//
// extract models referenced in tasks.
//
KisaoOntology kisaoInstance = KisaoOntology.getInstance();
// HashMap<String,Model> flattenedModels = new HashMap<String, Model>();
List<AbstractTask> taskList = sedml.getTasks();
for (AbstractTask task : taskList) {
String modelReference = task.getModelReference();
org.jlibsedml.Model sedmlOriginalModel = sedml.getModelWithId(modelReference);
String sbmlModelString = resolver.getModelString(sedmlOriginalModel);
// sbmlSource with all the changes applied
XMLSource sbmlSource = new XMLSource(sbmlModelString);
org.jlibsedml.Simulation sedmlSimulation = sedml.getSimulation(task.getSimulationReference());
Algorithm algorithm = sedmlSimulation.getAlgorithm();
KisaoTerm sedmlKisao = kisaoInstance.getTermById(algorithm.getKisaoID());
//
// try to find a VCell solverDescription to match the Kisao term
//
// UniformTimeCourse [initialTime=0.0, numberOfPoints=1000, outputEndTime=1.0, outputStartTime=0.0,
// Algorithm [kisaoID=KISAO:0000019], getId()=SimSlow]
// identify the vCell solvers that would match best the sedml solver kisao id
List<SolverDescription> solverDescriptions = new ArrayList<>();
for (SolverDescription sd : SolverDescription.values()) {
KisaoTerm solverKisaoTerm = kisaoInstance.getTermById(sd.getKisao());
if (solverKisaoTerm == null) {
break;
}
boolean isExactlySame = solverKisaoTerm.equals(sedmlKisao);
if (isExactlySame && !solverKisaoTerm.isObsolete()) {
// we make a list with all the solvers that match the kisao
solverDescriptions.add(sd);
}
}
if (solverDescriptions.isEmpty()) {
throw new RuntimeException("cannot find the solverDescription with exact match for Kisao term '" + sedmlKisao + "'");
}
// choose first one
SolverDescription solverDescription = solverDescriptions.get(0);
// find out everything else we need about the application we're going to use,
// some of the info will be needed when we parse the sbml file
boolean bSpatial = false;
Application appType = Application.NETWORK_DETERMINISTIC;
Set<SolverDescription.SolverFeature> sfList = solverDescription.getSupportedFeatures();
for (SolverDescription.SolverFeature sf : sfList) {
switch(sf) {
case Feature_Rulebased:
appType = Application.RULE_BASED_STOCHASTIC;
break;
case Feature_Stochastic:
appType = Application.NETWORK_STOCHASTIC;
break;
case Feature_Deterministic:
appType = Application.NETWORK_DETERMINISTIC;
break;
case Feature_Spatial:
bSpatial = true;
break;
default:
break;
}
}
BioModel bioModel = (BioModel) XmlHelper.importSBML(transLogger, sbmlSource, bSpatial);
//
// we already have an application loaded from the sbml file, with initial conditions and stuff
// which may be not be suitable because the sedml kisao may need a different app type
// so we do a "copy as" to the right type and then delete the original we loaded from the sbml file
//
// the new application we're making from the old one
SimulationContext newSimulationContext = null;
if (bioModel.getSimulationContexts().length == 1) {
SimulationContext oldSimulationContext = bioModel.getSimulationContext(0);
String newSCName = bioModel.getFreeSimulationContextName();
newSimulationContext = SimulationContext.copySimulationContext(oldSimulationContext, newSCName, bSpatial, appType);
bioModel.addSimulationContext(newSimulationContext);
bioModel.removeSimulationContext(oldSimulationContext);
} else {
newSimulationContext = bioModel.addNewSimulationContext("App1", appType);
}
//
// making the new vCell simulation based on the sedml simulation
//
newSimulationContext.refreshDependencies();
MathMappingCallback callback = new MathMappingCallbackTaskAdapter(progressListener);
newSimulationContext.refreshMathDescription(callback, NetworkGenerationRequirements.ComputeFullStandardTimeout);
Simulation newSimulation = new Simulation(newSimulationContext.getMathDescription());
newSimulation.setName(sedmlSimulation.getName());
bioModel.addSimulation(newSimulation);
// and set the vCell simulation parameters accordingly
if (sedmlSimulation instanceof UniformTimeCourse) {
} else if (sedmlSimulation instanceof OneStep) {
} else if (sedmlSimulation instanceof SteadyState) {
} else {
}
System.out.println(XmlHelper.bioModelToXML(bioModel));
}
}
use of cbit.vcell.mapping.SimulationContext.MathMappingCallback in project vcell by virtualcell.
the class SimulationServiceImpl method computeModel.
private SimulationInfo computeModel(BioModel bioModel, SimulationSpec simSpec, ClientTaskStatusSupport statusCallback) {
try {
SimulationContext simContext = bioModel.getSimulationContext(0);
MathMappingCallback callback = new MathMappingCallbackTaskAdapter(statusCallback);
Simulation newsim = simContext.addNewSimulation(SimulationOwner.DEFAULT_SIM_NAME_PREFIX, callback, NetworkGenerationRequirements.AllowTruncatedStandardTimeout);
SimulationInfo simulationInfo = new SimulationInfo();
simulationInfo.setId(Math.abs(new Random().nextInt(1000000)));
// ----------- run simulation(s)
final File localSimDataDir = ResourceUtil.getLocalSimDir(User.tempUser.getName());
Simulation simulation = new TempSimulation(newsim, false);
final SimulationServiceContext simServiceContext = new SimulationServiceContext();
simServiceContext.simInfo = simulationInfo;
simServiceContext.simState = SimulationState.running;
simServiceContext.simTask = new SimulationTask(new SimulationJob(simulation, 0, null), 0);
simServiceContext.vcDataIdentifier = simServiceContext.simTask.getSimulationJob().getVCDataIdentifier();
simServiceContext.solver = createQuickRunSolver(localSimDataDir, simServiceContext.simTask);
simServiceContext.localSimDataDir = localSimDataDir;
if (simServiceContext.solver == null) {
throw new RuntimeException("null solver");
}
sims.put(simulationInfo.id, simServiceContext);
simServiceContext.solver.addSolverListener(new SolverListener() {
public void solverStopped(SolverEvent event) {
simServiceContext.simState = SimulationState.failed;
System.err.println("Simulation stopped");
}
public void solverStarting(SolverEvent event) {
simServiceContext.simState = SimulationState.running;
updateStatus(event);
}
public void solverProgress(SolverEvent event) {
simServiceContext.simState = SimulationState.running;
updateStatus(event);
}
public void solverPrinted(SolverEvent event) {
simServiceContext.simState = SimulationState.running;
}
public void solverFinished(SolverEvent event) {
try {
getDataSetController(simServiceContext).getDataSetTimes(simServiceContext.vcDataIdentifier);
simServiceContext.simState = SimulationState.done;
} catch (DataAccessException e) {
simServiceContext.simState = SimulationState.failed;
e.printStackTrace();
}
updateStatus(event);
}
public void solverAborted(SolverEvent event) {
simServiceContext.simState = SimulationState.failed;
System.err.println(event.getSimulationMessage().getDisplayMessage());
}
private void updateStatus(SolverEvent event) {
if (statusCallback == null)
return;
statusCallback.setMessage(event.getSimulationMessage().getDisplayMessage());
statusCallback.setProgress((int) (event.getProgress() * 100));
}
});
simServiceContext.solver.startSolver();
return simServiceContext.simInfo;
} catch (Exception e) {
e.printStackTrace(System.out);
// remember the exceptiopn ... fail the status ... save the error message
return new SimulationInfo().setId(1);
}
}
use of cbit.vcell.mapping.SimulationContext.MathMappingCallback in project vcell by virtualcell.
the class ClientRequestManager method createRuleBasedBioModelFromApplication.
public void createRuleBasedBioModelFromApplication(final BioModelWindowManager requester, final String name, final SimulationContext simContext) {
if (simContext == null) {
PopupGenerator.showErrorDialog(requester, "Selected Application is null, cannot generate corresponding bio model");
return;
}
AsynchClientTask task1 = new AsynchClientTask("Creating BioModel from BioModel Application", AsynchClientTask.TASKTYPE_NONSWING_BLOCKING) {
@Override
public void run(Hashtable<String, Object> hashTable) throws Exception {
MathMappingCallback dummyCallback = new MathMappingCallback() {
public void setProgressFraction(float percentDone) {
}
public void setMessage(String message) {
}
public boolean isInterrupted() {
return false;
}
};
MathMapping transformedMathMapping = simContext.createNewMathMapping(dummyCallback, NetworkGenerationRequirements.ComputeFullStandardTimeout);
// simContext.setMathDescription(transformedMathMapping.getMathDescription());
BioModel newBioModel = new BioModel(null);
SimulationContext transformedSimContext = transformedMathMapping.getTransformation().transformedSimContext;
Model model = transformedSimContext.getModel();
// for(ReactionStep rs : model.getReactionSteps()) {
// model.removeReactionStep(rs);
// }
newBioModel.setModel(model);
hashTable.put("newBioModel", newBioModel);
}
};
AsynchClientTask task2 = new AsynchClientTask("Creating BioModel from BioModel Application", AsynchClientTask.TASKTYPE_SWING_BLOCKING) {
@Override
public void run(Hashtable<String, Object> hashTable) throws Exception {
BioModel newBioModel = (BioModel) hashTable.get("newBioModel");
DocumentWindowManager windowManager = createDocumentWindowManager(newBioModel);
getMdiManager().createNewDocumentWindow(windowManager);
}
};
ClientTaskDispatcher.dispatch(requester.getComponent(), new Hashtable<String, Object>(), new AsynchClientTask[] { task1, task2 }, false);
}
use of cbit.vcell.mapping.SimulationContext.MathMappingCallback in project vcell by virtualcell.
the class XmlHelper method sedmlToBioModel.
public static VCDocument sedmlToBioModel(VCLogger transLogger, ExternalDocInfo externalDocInfo, SedML sedml, AbstractTask selectedTask) throws Exception {
if (sedml.getModels().isEmpty()) {
return null;
}
VCDocument doc = null;
try {
// extract the path only from the sedml file
String fullPath = FileUtils.getFullPath(externalDocInfo.getFile().getAbsolutePath());
// Namespace namespace = sedml.getNamespace();
// iterate through all the elements and show them at the console
List<org.jlibsedml.Model> mmm = sedml.getModels();
for (Model mm : mmm) {
System.out.println(mm.toString());
}
List<org.jlibsedml.Simulation> sss = sedml.getSimulations();
for (org.jlibsedml.Simulation ss : sss) {
System.out.println(ss.toString());
}
List<AbstractTask> ttt = sedml.getTasks();
for (AbstractTask tt : ttt) {
System.out.println(tt.toString());
}
List<DataGenerator> ddd = sedml.getDataGenerators();
for (DataGenerator dd : ddd) {
System.out.println(dd.toString());
}
List<Output> ooo = sedml.getOutputs();
for (Output oo : ooo) {
System.out.println(oo.toString());
}
KisaoTerm sedmlKisao = null;
// this will become the vCell simulation
org.jlibsedml.Simulation sedmlSimulation = null;
// the "original" model referred to by the task
org.jlibsedml.Model sedmlOriginalModel = null;
String sedmlOriginalModelName = null;
if (selectedTask == null) {
// no task, just pick the Model and find its sbml file
sedmlOriginalModelName = SEDMLUtil.getName(mmm.get(0));
} else {
if (selectedTask instanceof Task) {
sedmlOriginalModel = sedml.getModelWithId(selectedTask.getModelReference());
sedmlSimulation = sedml.getSimulation(selectedTask.getSimulationReference());
} else if (selectedTask instanceof RepeatedTask) {
RepeatedTask rt = (RepeatedTask) selectedTask;
assert (rt.getSubTasks().size() == 1);
// first (and only) subtask
SubTask st = rt.getSubTasks().entrySet().iterator().next().getValue();
String taskId = st.getTaskId();
AbstractTask t = sedml.getTaskWithId(taskId);
// get model and simulation from subtask
sedmlOriginalModel = sedml.getModelWithId(t.getModelReference());
sedmlSimulation = sedml.getSimulation(t.getSimulationReference());
} else {
throw new RuntimeException("Unexpected task " + selectedTask);
}
sedmlOriginalModelName = sedmlOriginalModel.getId();
sedmlKisao = KisaoOntology.getInstance().getTermById(sedmlSimulation.getAlgorithm().getKisaoID());
}
// UniformTimeCourse [initialTime=0.0, numberOfPoints=1000, outputEndTime=1.0, outputStartTime=0.0,
// Algorithm [kisaoID=KISAO:0000019], getId()=SimSlow]
// identify the vCell solvers that would match best the sedml solver kisao id
List<SolverDescription> solverDescriptions = new ArrayList<>();
for (SolverDescription sd : SolverDescription.values()) {
KisaoTerm solverKisaoTerm = KisaoOntology.getInstance().getTermById(sd.getKisao());
if (solverKisaoTerm == null) {
break;
}
boolean isExactlySame = solverKisaoTerm.equals(sedmlKisao);
if (isExactlySame && !solverKisaoTerm.isObsolete()) {
// we make a list with all the solvers that match the kisao
solverDescriptions.add(sd);
}
}
// from the list of vcell solvers that match the sedml kisao we select the ones that have a matching time step
SolverDescription solverDescription = null;
for (SolverDescription sd : solverDescriptions) {
if (true) {
solverDescription = sd;
break;
}
}
// find out everything else we need about the application we're going to use,
// some of the info will be needed when we parse the sbml file
boolean bSpatial = false;
Application appType = Application.NETWORK_DETERMINISTIC;
Set<SolverDescription.SolverFeature> sfList = solverDescription.getSupportedFeatures();
for (SolverDescription.SolverFeature sf : sfList) {
switch(sf) {
case Feature_Rulebased:
appType = Application.RULE_BASED_STOCHASTIC;
break;
case Feature_Stochastic:
appType = Application.NETWORK_STOCHASTIC;
break;
case Feature_Deterministic:
appType = Application.NETWORK_DETERMINISTIC;
break;
case Feature_Spatial:
bSpatial = true;
break;
default:
break;
}
}
// -------------------------------------------------------------------------------------------
// extract bioModel name from sedx (or sedml) file
String bioModelName = FileUtils.getBaseName(externalDocInfo.getFile().getAbsolutePath());
// if we have repeated task, we ignore them, we just use the normal resolvers for archive and changes
// once the application and simulation are built, we iterate through the repeated tasks and
// add math overrides to the simulation for each repeated task
ArchiveComponents ac = null;
if (externalDocInfo.getFile().getPath().toLowerCase().endsWith("sedx") || externalDocInfo.getFile().getPath().toLowerCase().endsWith("omex")) {
ac = Libsedml.readSEDMLArchive(new FileInputStream(externalDocInfo.getFile().getPath()));
}
ModelResolver resolver = new ModelResolver(sedml);
if (ac != null) {
resolver.add(new ArchiveModelResolver(ac));
}
resolver.add(new FileModelResolver());
resolver.add(new RelativeFileModelResolver(fullPath));
String newMdl = resolver.getModelString(sedmlOriginalModel);
// sbmlSource with all the changes applied
XMLSource sbmlSource = new XMLSource(newMdl);
doc = XmlHelper.importSBML(transLogger, sbmlSource, bSpatial);
BioModel bioModel = (BioModel) doc;
bioModel.setName(bioModelName);
// we already have an application loaded from the sbml file, with initial conditions and stuff
// which may be not be suitable because the sedml kisao may need a different app type
// so we do a "copy as" to the right type and then delete the original we loaded from the sbml file
// the new application we're making from the old one
SimulationContext newSimulationContext = null;
if (bioModel.getSimulationContexts().length == 1) {
SimulationContext oldSimulationContext = bioModel.getSimulationContext(0);
newSimulationContext = SimulationContext.copySimulationContext(oldSimulationContext, sedmlOriginalModelName, bSpatial, appType);
bioModel.removeSimulationContext(oldSimulationContext);
bioModel.addSimulationContext(newSimulationContext);
} else {
// length == 0
newSimulationContext = bioModel.addNewSimulationContext(sedmlOriginalModelName, appType);
}
// making the new vCell simulation based on the sedml simulation
newSimulationContext.refreshDependencies();
MathMappingCallback callback = new MathMappingCallbackTaskAdapter(null);
newSimulationContext.refreshMathDescription(callback, NetworkGenerationRequirements.ComputeFullStandardTimeout);
Simulation newSimulation = new Simulation(newSimulationContext.getMathDescription());
newSimulation.setName(SEDMLUtil.getName(sedmlSimulation));
// TODO: make sure that everything has proper names
// we check the repeated tasks, if any, and add to the list of math overrides
// if(selectedTask instanceof RepeatedTask) {
// for(Change change : ((RepeatedTask) selectedTask).getChanges()) {
// if(!(change instanceof SetValue)) {
// throw new RuntimeException("Only 'SetValue' changes are supported for repeated tasks.");
// }
// SetValue setValue = (SetValue)change;
// // TODO: extract target from XPath
// // ......
// //
// String target = "s0"; // for now we just use a hardcoded thing
// ConstantArraySpec cas;
// Range range = ((RepeatedTask) selectedTask).getRange(setValue.getRangeReference());
// if(range instanceof UniformRange) {
// cas = ConstantArraySpec.createIntervalSpec(target, ((UniformRange) range).getStart(), ((UniformRange) range).getEnd(),
// range.getNumElements(), ((UniformRange) range).getType() == UniformRange.UniformType.LOG ? true : false);
// } else if(range instanceof VectorRange) {
// // List<String> constants = new ArrayList<> ();
// // for(int i=0; i<range.getNumElements(); i++) {
// // constants.add(new Constant(i+"", new Expression(range.getElementAt(i))));
// // }
// // cas = ConstantArraySpec.createListSpec(target, constants);
//
// } else {
// throw new RuntimeException("Only 'Uniform Range' and 'Vector Range' are supported at this time.");
// }
//
// }
// }
// we identify the type of sedml simulation (uniform time course, etc)
// and set the vCell simulation parameters accordingly
SolverTaskDescription simTaskDesc = newSimulation.getSolverTaskDescription();
TimeBounds timeBounds = new TimeBounds();
TimeStep timeStep = new TimeStep();
double outputTimeStep = 0.1;
if (sedmlSimulation instanceof UniformTimeCourse) {
// we translate initial time to zero, we provide output for the duration of the simulation
// because we can't select just an interval the way the SEDML simulation can
double initialTime = ((UniformTimeCourse) sedmlSimulation).getInitialTime();
double outputStartTime = ((UniformTimeCourse) sedmlSimulation).getOutputStartTime();
double outputEndTime = ((UniformTimeCourse) sedmlSimulation).getOutputEndTime();
double outputNumberOfPoints = ((UniformTimeCourse) sedmlSimulation).getNumberOfPoints();
outputTimeStep = (outputEndTime - outputStartTime) / outputNumberOfPoints;
timeBounds = new TimeBounds(0, outputEndTime - initialTime);
} else if (sedmlSimulation instanceof OneStep) {
// for anything other than UniformTimeCourse we just ignore
} else if (sedmlSimulation instanceof SteadyState) {
} else {
}
OutputTimeSpec outputTimeSpec = new UniformOutputTimeSpec(outputTimeStep);
simTaskDesc.setTimeBounds(timeBounds);
simTaskDesc.setTimeStep(timeStep);
simTaskDesc.setOutputTimeSpec(outputTimeSpec);
newSimulation.setSolverTaskDescription(simTaskDesc);
bioModel.addSimulation(newSimulation);
newSimulation.refreshDependencies();
} catch (Exception e) {
e.printStackTrace();
throw new RuntimeException("Unable to initialize bioModel for the given selection.");
}
return doc;
}
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